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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1974 2
1975 5
1976 4
1977 14
1978 9
1979 5
1980 14
1981 9
1982 13
1983 11
1984 15
1985 9
1986 10
1987 8
1988 16
1989 16
1990 11
1991 16
1992 19
1993 23
1994 28
1995 29
1996 36
1997 45
1998 34
1999 39
2000 56
2001 27
2002 37
2003 50
2004 57
2005 69
2006 67
2007 68
2008 57
2009 54
2010 53
2011 58
2012 57
2013 41
2014 32
2015 28
2016 40
2017 28
2018 20
2019 23
2020 15
2021 11
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1,291 results
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Page 1
Therapeutic drug monitoring of valproic acid.
Shaikh AS, Liu H, Li Y, Cao L, Guo R. Shaikh AS, et al. Pak J Pharm Sci. 2018 Jul;31(4(Special)):1773-1776. Pak J Pharm Sci. 2018. PMID: 30203778 Clinical Trial.
The present study is drug monitoring of valproic acid and comparative evaluation of therapeutic monitoring results of valproic acid for assessment of clinical response, safety and toxicity in different age and gender groups of Chinese epileptic patient …
The present study is drug monitoring of valproic acid and comparative evaluation of therapeutic monitoring results of valpr
A randomized controlled trial comparing lithium plus valproic acid versus lithium plus carbamazepine in young patients with type 1 bipolar disorder: the LICAVAL study.
Missio G, Moreno DH, Demetrio FN, Soeiro-de-Souza MG, Dos Santos Fernandes F, Barros VB, Moreno RA. Missio G, et al. Trials. 2019 Oct 26;20(1):608. doi: 10.1186/s13063-019-3655-2. Trials. 2019. PMID: 31655626 Free PMC article. Clinical Trial.
BACKGROUND: Treatment of bipolar disorder (BD) usually requires drug combinations. Combinations of lithium plus valproic acid (Li/VPA) and lithium plus carbamazepine (Li/CBZ) are used in clinical practice but were not previously compared in a head-to-head trial. ...
BACKGROUND: Treatment of bipolar disorder (BD) usually requires drug combinations. Combinations of lithium plus valproic acid
Safety and Tolerability of Intravenous Valproic Acid in Healthy Subjects: A Phase I Dose-Escalation Trial.
Georgoff PE, Nikolian VC, Bonham T, Pai MP, Tafatia C, Halaweish I, To K, Watcharotone K, Parameswaran A, Luo R, Sun D, Alam HB. Georgoff PE, et al. Clin Pharmacokinet. 2018 Feb;57(2):209-219. doi: 10.1007/s40262-017-0553-1. Clin Pharmacokinet. 2018. PMID: 28497259 Free PMC article. Clinical Trial.
In animal models of traumatic injury, a single dose of valproic acid has been shown to reduce mortality. The purpose of this trial was to determine the maximum tolerated single dose of intravenous valproic acid in healthy humans. ...Next, the safety an …
In animal models of traumatic injury, a single dose of valproic acid has been shown to reduce mortality. The purpose of this t …
Phase I trial of valproic acid and lenalidomide in patients with advanced cancer.
Bilen MA, Fu S, Falchook GS, Ng CS, Wheler JJ, Abdelrahim M, Erguvan-Dogan B, Hong DS, Tsimberidou AM, Kurzrock R, Naing A. Bilen MA, et al. Cancer Chemother Pharmacol. 2015 Apr;75(4):869-74. doi: 10.1007/s00280-015-2695-x. Epub 2015 Feb 10. Cancer Chemother Pharmacol. 2015. PMID: 25666183 Clinical Trial.
PURPOSE: The objectives of this study were to evaluate the tolerability and efficacy of valproic acid (VPA) and lenalidomide. METHODS: In this 3+3 design study, VPA was administered daily on a 7-day-on, 7-day-off schedule, and lenalidomide was administered daily for …
PURPOSE: The objectives of this study were to evaluate the tolerability and efficacy of valproic acid (VPA) and lenalidomide. …
Clinical and biological effects of valproic acid as a histone deacetylase inhibitor on tumor and surrogate tissues: phase I/II trial of valproic acid and epirubicin/FEC.
Munster P, Marchion D, Bicaku E, Lacevic M, Kim J, Centeno B, Daud A, Neuger A, Minton S, Sullivan D. Munster P, et al. Clin Cancer Res. 2009 Apr 1;15(7):2488-96. doi: 10.1158/1078-0432.CCR-08-1930. Epub 2009 Mar 24. Clin Cancer Res. 2009. PMID: 19318486 Free article. Clinical Trial.
PURPOSE: The aim was to study the biological and molecular effects of the histone deacetylase (HDAC) inhibitor, valproic acid, in patients with solid tumor malignancies. EXPERIMENTAL DESIGN: A phase I dose escalation of valproic acid given on days 1 to …
PURPOSE: The aim was to study the biological and molecular effects of the histone deacetylase (HDAC) inhibitor, valproic acid, …
Lower effectiveness of divalproex versus valproic acid in a prospective, quasi-experimental clinical trial involving 9,260 psychiatric admissions.
Wassef AA, Winkler DE, Roache AL, Abobo VB, Lopez LM, Averill JP, Mian AI, Overall JE. Wassef AA, et al. Am J Psychiatry. 2005 Feb;162(2):330-9. doi: 10.1176/appi.ajp.162.2.330. Am J Psychiatry. 2005. PMID: 15677599 Clinical Trial.
OBJECTIVE: The authors examined clinical differences between divalproex sodium and generic immediate-release valproic acid. METHOD: This 6-year prospective, quasi-experimental clinical trial compared the effectiveness and tolerability of divalproex and valproic
OBJECTIVE: The authors examined clinical differences between divalproex sodium and generic immediate-release valproic acid. ME …
Potentiation of a topoisomerase I inhibitor, karenitecin, by the histone deacetylase inhibitor valproic acid in melanoma: translational and phase I/II clinical trial.
Daud AI, Dawson J, DeConti RC, Bicaku E, Marchion D, Bastien S, Hausheer FA 3rd, Lush R, Neuger A, Sullivan DM, Munster PN. Daud AI, et al. Clin Cancer Res. 2009 Apr 1;15(7):2479-87. doi: 10.1158/1078-0432.CCR-08-1931. Epub 2009 Mar 24. Clin Cancer Res. 2009. PMID: 19318485 Free article. Clinical Trial.
EXPERIMENTAL DESIGN: Apoptosis, COMET, and xenograft experiments were carried out as described previously. A phase I/II trial of valproic acid (VPA) and KTN was conducted in patients with stage IV melanoma, with any number of prior therapies, Eastern Cooperative Onc …
EXPERIMENTAL DESIGN: Apoptosis, COMET, and xenograft experiments were carried out as described previously. A phase I/II trial of valproic
Valproic acid in epilepsy: clinical and pharmacological effects.
Mattson RH, Cramer JA, Williamson PD, Novelly RA. Mattson RH, et al. Ann Neurol. 1978 Jan;3(1):20-5. doi: 10.1002/ana.410030105. Ann Neurol. 1978. PMID: 350128 Clinical Trial.
The antiepileptic drug valproic acid was studied in an open clinical trial as adjunct medication for 23 patients with uncontrolled seizures of a generalized or partial type. ...The quantity of unbound phenytoin was relatively stable throughout. This observation was …
The antiepileptic drug valproic acid was studied in an open clinical trial as adjunct medication for 23 patients with uncontro …
Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy: initial monotherapy outcomes at 12 months.
Glauser TA, Cnaan A, Shinnar S, Hirtz DG, Dlugos D, Masur D, Clark PO, Adamson PC; Childhood Absence Epilepsy Study Team. Glauser TA, et al. Epilepsia. 2013 Jan;54(1):141-55. doi: 10.1111/epi.12028. Epub 2012 Nov 21. Epilepsia. 2013. PMID: 23167925 Free PMC article. Clinical Trial.
At the month 12 visit, the freedom-from-failure rates for ethosuximide and valproic acid were similar (45% and 44%, respectively; odds ratio [OR]with valproic acid vs. ethosuximide 0.94; 95% confidence interval [CI] 0.58-1.52; p = 0.82) and were higher …
At the month 12 visit, the freedom-from-failure rates for ethosuximide and valproic acid were similar (45% and 44%, respective …
No pharmacokinetic interaction between lacosamide and valproic acid in healthy volunteers.
Cawello W, Bonn R. Cawello W, et al. J Clin Pharmacol. 2012 Nov;52(11):1739-48. doi: 10.1177/0091270011426875. Epub 2011 Dec 8. J Clin Pharmacol. 2012. PMID: 22162508 Clinical Trial.
Two open-label, randomized, multiple-dose clinical studies evaluated the potential for pharmacokinetic interaction between the antiepileptic drugs lacosamide and valproic acid. The influence of lacosamide on valproic acid pharmacokinetics (trial A) and …
Two open-label, randomized, multiple-dose clinical studies evaluated the potential for pharmacokinetic interaction between the antiepileptic …
1,291 results