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Year Number of Results
2006 10
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439 results

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Page 1
Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial.
Anthenelli RM, Benowitz NL, West R, St Aubin L, McRae T, Lawrence D, Ascher J, Russ C, Krishen A, Evins AE. Anthenelli RM, et al. Lancet. 2016 Jun 18;387(10037):2507-20. doi: 10.1016/S0140-6736(16)30272-0. Epub 2016 Apr 22. Lancet. 2016. PMID: 27116918 Free article. Clinical Trial.
We compared the relative neuropsychiatric safety risk and efficacy of varenicline and bupropion with nicotine patch and placebo in smokers with and without psychiatric disorders. ...INTERPRETATION: The study did not show a significant increase in neuropsychiatric adverse e …
We compared the relative neuropsychiatric safety risk and efficacy of varenicline and bupropion with nicotine patch and placebo in sm …
Cytisinicline for Smoking Cessation: A Randomized Clinical Trial.
Rigotti NA, Benowitz NL, Prochaska J, Leischow S, Nides M, Blumenstein B, Clarke A, Cain D, Jacobs C. Rigotti NA, et al. JAMA. 2023 Jul 11;330(2):152-160. doi: 10.1001/jama.2023.10042. JAMA. 2023. PMID: 37432430 Free PMC article. Clinical Trial.
IMPORTANCE: Cytisinicline (cytisine) is a plant-based alkaloid that, like varenicline, binds selectively to alpha4beta2 nicotinic acetylcholine receptors, which mediate nicotine dependence. ...
IMPORTANCE: Cytisinicline (cytisine) is a plant-based alkaloid that, like varenicline, binds selectively to alpha4beta2 nicotinic ace …
Effect of Cytisine vs Varenicline on Smoking Cessation: A Randomized Clinical Trial.
Courtney RJ, McRobbie H, Tutka P, Weaver NA, Petrie D, Mendelsohn CP, Shakeshaft A, Talukder S, Macdonald C, Thomas D, Kwan BCH, Walker N, Gartner C, Mattick RP, Paul C, Ferguson SG, Zwar NA, Richmond RL, Doran CM, Boland VC, Hall W, West R, Farrell M. Courtney RJ, et al. JAMA. 2021 Jul 6;326(1):56-64. doi: 10.1001/jama.2021.7621. JAMA. 2021. PMID: 34228066 Free PMC article. Clinical Trial.
However, cytisine has not been tested against the most effective smoking cessation medication, varenicline, which is associated with adverse events known to lead to discontinuation of therapy. ...Verified 6-month continuous abstinence rates were 11.7% for the cytisine grou …
However, cytisine has not been tested against the most effective smoking cessation medication, varenicline, which is associated with …
Varenicline and counseling for vaping cessation: a double-blind, randomized, parallel-group, placebo-controlled trial.
Caponnetto P, Campagna D, Ahluwalia JS, Russell C, Maglia M, Riela PM, Longo CF, Busa B, Polosa R. Caponnetto P, et al. BMC Med. 2023 Jul 5;21(1):220. doi: 10.1186/s12916-023-02919-2. BMC Med. 2023. PMID: 37403047 Free PMC article. Clinical Trial.
RESULTS: CAR was significantly higher for varenicline vs placebo at each interval: weeks 4-12, 40.0% and 20.0%, respectively (OR = 2.67, 95% CI = [1.25-5.68], P = 0.011); weeks 4-24, 34.3% for varenicline with counseling and 17.2% for placebo with counseling (OR = 2 …
RESULTS: CAR was significantly higher for varenicline vs placebo at each interval: weeks 4-12, 40.0% and 20.0%, respectively (OR = 2. …
Smoking Cessation After Initial Treatment Failure With Varenicline or Nicotine Replacement: A Randomized Clinical Trial.
Cinciripini PM, Green CE, Shete S, Minnix JA, Robinson JD, Cui Y, Kim S, Kypriotakis G, Beneventi D, Blalock JA, Versace F, Karam-Hage M. Cinciripini PM, et al. JAMA. 2024 May 28;331(20):1722-1731. doi: 10.1001/jama.2024.4183. JAMA. 2024. PMID: 38696203 Free PMC article. Clinical Trial.
INTERVENTIONS: The initial treatment was 2 mg/d of varenicline or the combined replacement therapy of a 21-mg patch plus 2-mg lozenge. The rerandomized participants either continued with their initial therapies, switched between varenicline and CNRT, or increased do …
INTERVENTIONS: The initial treatment was 2 mg/d of varenicline or the combined replacement therapy of a 21-mg patch plus 2-mg lozenge …
Effects of Combined Varenicline With Nicotine Patch and of Extended Treatment Duration on Smoking Cessation: A Randomized Clinical Trial.
Baker TB, Piper ME, Smith SS, Bolt DM, Stein JH, Fiore MC. Baker TB, et al. JAMA. 2021 Oct 19;326(15):1485-1493. doi: 10.1001/jama.2021.15333. JAMA. 2021. PMID: 34665204 Free PMC article. Clinical Trial.
IMPORTANCE: Smoking cessation medications are routinely used in health care. Research suggests that combining varenicline with the nicotine patch, extending the duration of varenicline treatment, or both, may increase cessation effectiveness. ...INTERVENTIONS: All p …
IMPORTANCE: Smoking cessation medications are routinely used in health care. Research suggests that combining varenicline with the ni …
Electronic Cigarettes vs Varenicline for Smoking Cessation in Adults: A Randomized Clinical Trial.
Tuisku A, Rahkola M, Nieminen P, Toljamo T. Tuisku A, et al. JAMA Intern Med. 2024 Aug 1;184(8):915-921. doi: 10.1001/jamainternmed.2024.1822. JAMA Intern Med. 2024. PMID: 38884987 Clinical Trial.

The primary outcome occurred in 61 of 152 participants (40.4%) in the EC group, 67 of 153 (43.8%) in the varenicline group, and 30 of 153 (19.7%) in the placebo group (P < .001). In the pairwise comparison, placebo differed statistically significantly from ECs (risk dif

…
The primary outcome occurred in 61 of 152 participants (40.4%) in the EC group, 67 of 153 (43.8%) in the varenicline group, and 30 of …
Efficacy and Safety of OC-01 (Varenicline Solution) Nasal Spray on Signs and Symptoms of Dry Eye Disease: The ONSET-2 Phase 3 Randomized Trial.
Wirta D, Vollmer P, Paauw J, Chiu KH, Henry E, Striffler K, Nau J; ONSET-2 Study Group. Wirta D, et al. Ophthalmology. 2022 Apr;129(4):379-387. doi: 10.1016/j.ophtha.2021.11.004. Epub 2021 Nov 10. Ophthalmology. 2022. PMID: 34767866 Free article. Clinical Trial.
PURPOSE: To evaluate the efficacy and safety of OC-01 (varenicline solution) nasal spray for treatment of patients with dry eye disease. DESIGN: Randomized, multicenter, double-masked, vehicle-controlled, phase 3 study. ...
PURPOSE: To evaluate the efficacy and safety of OC-01 (varenicline solution) nasal spray for treatment of patients with dry eye disea …
Varenicline and Nicotine Replacement Therapy for Smokers Admitted to Hospitals: A Randomized Clinical Trial.
Weeks GR, Gobarani RK, Abramson MJ, Bonevski B, Webb A, Thomas D, Paul E, Sarwar MR, Smith BJ, Perinpanathan S, Kirsa S, Parkinson J, Meanger D, Coward L, Rofe O, Lee P, van den Bosch D, George J. Weeks GR, et al. JAMA Netw Open. 2024 Jun 3;7(6):e2418120. doi: 10.1001/jamanetworkopen.2024.18120. JAMA Netw Open. 2024. PMID: 38935378 Free PMC article. Clinical Trial.
OBJECTIVE: To examine whether hospitalized smokers treated with varenicline and NRT lozenges achieve higher prolonged smoking abstinence rates compared with those treated with varenicline alone. ...CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of the …
OBJECTIVE: To examine whether hospitalized smokers treated with varenicline and NRT lozenges achieve higher prolonged smoking abstine …
Matching-adjusted indirect comparison of phase 3 clinical trial outcomes of OC-01 (varenicline solution) nasal spray and lifitegrast 5% ophthalmic solution for the treatment of dry eye disease.
White DE, Hendrix LH, Sun L, Tam I, Macsai M, Gibson AA. White DE, et al. J Manag Care Spec Pharm. 2023 Jan;29(1):69-79. doi: 10.18553/jmcp.2022.22208. Epub 2022 Aug 28. J Manag Care Spec Pharm. 2023. PMID: 36030415 Free PMC article. Clinical Trial.
OBJECTIVE: To compare the efficacy of OC-01 (varenicline solution) 0.03 mg nasal spray (OC-01 VNS) to lifitegrast 5% ophthalmic solution on tear production and patient-reported eye dryness in patients with dry eye disease (DED) using data from phase 3 clinical trials via M …
OBJECTIVE: To compare the efficacy of OC-01 (varenicline solution) 0.03 mg nasal spray (OC-01 VNS) to lifitegrast 5% ophthalmic solut …
439 results