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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1994 1
1998 2
1999 5
2000 7
2002 3
2003 3
2004 5
2005 3
2006 4
2007 1
2008 1
2009 1
2011 2
2013 2
2014 3
2019 3
2021 1
2024 0

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47 results

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Page 1
Effects of zolpidem and zaleplon on cognitive performance after emergent morning awakenings at Tmax: a randomized placebo-controlled trial.
Dinges DF, Basner M, Ecker AJ, Baskin P, Johnston SL. Dinges DF, et al. Sleep. 2019 Mar 1;42(3):zsy258. doi: 10.1093/sleep/zsy258. Sleep. 2019. PMID: 30576525 Clinical Trial.
To evaluate the risk to operational safety, a ground-based, double-blind, placebo-controlled study on the emergent awakening effects of zolpidem and zaleplon was conducted. METHODS: N = 34 participants (age M = 42.1 9.7; 25 males; 9 Astronauts, 7 Astronaut candidates, and …
To evaluate the risk to operational safety, a ground-based, double-blind, placebo-controlled study on the emergent awakening effects of zolp …
Zaleplon and triazolam in humans: acute behavioral effects and abuse potential.
Rush CR, Frey JM, Griffiths RR. Rush CR, et al. Psychopharmacology (Berl). 1999 Jul;145(1):39-51. doi: 10.1007/s002130051030. Psychopharmacology (Berl). 1999. PMID: 10445371 Clinical Trial.
Unlike most benzodiazepines, zaleplon binds selectively to the BZ1 (omega1) subtype of the benzodiazepine receptor. ...Zaleplon and triazolam produced comparable dose-related effects on several subject-rated drug-effect questionnaires. ...
Unlike most benzodiazepines, zaleplon binds selectively to the BZ1 (omega1) subtype of the benzodiazepine receptor. ...Zaleplon
Zaleplon pharmacokinetics and absolute bioavailability.
Rosen AS, Fournié P, Darwish M, Danjou P, Troy SM. Rosen AS, et al. Biopharm Drug Dispos. 1999 Apr;20(3):171-5. doi: 10.1002/(sici)1099-081x(199904)20:3<171::aid-bdd169>3.0.co;2-k. Biopharm Drug Dispos. 1999. PMID: 10211871 Clinical Trial.
Subjects received 1 and 2.5 mg intravenous (i.v.) infusions of zaleplon during the first and second periods, respectively, and then were randomly assigned to receive a 5 mg oral dose or 5 mg i.v. infusion of zaleplon in a crossover design during the final two period …
Subjects received 1 and 2.5 mg intravenous (i.v.) infusions of zaleplon during the first and second periods, respectively, and then w …
Comparative kinetics and dynamics of zaleplon, zolpidem, and placebo.
Greenblatt DJ, Harmatz JS, von Moltke LL, Ehrenberg BL, Harrel L, Corbett K, Counihan M, Graf JA, Darwish M, Mertzanis P, Martin PT, Cevallos WH, Shader RI. Greenblatt DJ, et al. Clin Pharmacol Ther. 1998 Nov;64(5):553-61. doi: 10.1016/S0009-9236(98)90139-4. Clin Pharmacol Ther. 1998. PMID: 9834048 Clinical Trial.
METHOD: Ten healthy male volunteers received single oral doses of placebo, 10 mg zaleplon, 20 mg zaleplon, 10 mg zolpidem, and 20 mg zolpidem in a double-blind, 5-condition crossover study, with 48 hours elapsing between trials. ...The overall order of agonist poten …
METHOD: Ten healthy male volunteers received single oral doses of placebo, 10 mg zaleplon, 20 mg zaleplon, 10 mg zolpidem, and …
Lemborexant for the Treatment of Insomnia: Direct and Indirect Comparisons With Other Hypnotics Using Number Needed to Treat, Number Needed to Harm, and Likelihood to Be Helped or Harmed.
Citrome L, Juday T, Frech F, Atkins N Jr. Citrome L, et al. J Clin Psychiatry. 2021 Jun 1;82:20m13795. doi: 10.4088/JCP.20m13795. J Clin Psychiatry. 2021. PMID: 34077032 Free article. Clinical Trial.
Direct comparisons were made with zolpidem extended release (ER), and indirect comparisons were made with other hypnotic agents, including suvorexant, doxepin, ramelteon, zolpidem immediate release, eszopiclone, zaleplon, and selected benzodiazepines, using data from publi …
Direct comparisons were made with zolpidem extended release (ER), and indirect comparisons were made with other hypnotic agents, including s …
Zaleplon shortens subjective sleep latency and improves subjective sleep quality in elderly patients with insomnia. The Zaleplon Clinical Investigator Study Group.
Hedner J, Yaeche R, Emilien G, Farr I, Salinas E. Hedner J, et al. Int J Geriatr Psychiatry. 2000 Aug;15(8):704-12. doi: 10.1002/1099-1166(200008)15:8<704::aid-gps183>3.0.co;2-s. Int J Geriatr Psychiatry. 2000. PMID: 10960882 Clinical Trial.
The pharmacology and pharmacokinetics of Zaleplon suggest a safety profile that is improved over other hypnotics. ...Subjective sleep quality was improved for significantly more patients treated with zaleplon 10 mg than those treated with placebo during both weeks o …
The pharmacology and pharmacokinetics of Zaleplon suggest a safety profile that is improved over other hypnotics. ...Subjective sleep …
Pharmacokinetics, pharmacodynamics, and relative pharmacokinetic/pharmacodynamic profiles of zaleplon and zolpidem.
Drover D, Lemmens H, Naidu S, Cevallos W, Darwish M, Stanski D. Drover D, et al. Clin Ther. 2000 Dec;22(12):1443-61. doi: 10.1016/s0149-2918(00)83043-x. Clin Ther. 2000. PMID: 11192136 Clinical Trial.
Zaleplon produced less sedation than zolpidem at the 2 doses studied (P < 0.001). ...Zaleplon had no effect on recent or remote recall, whereas zolpidem had a significant effect on both measures (P < 0.05). ...
Zaleplon produced less sedation than zolpidem at the 2 doses studied (P < 0.001). ...Zaleplon had no effect on recent or re
Zaleplon improves sleep without producing rebound effects in outpatients with insomnia. Zaleplon Clinical Study Group.
Fry J, Scharf M, Mangano R, Fujimori M. Fry J, et al. Int Clin Psychopharmacol. 2000 May;15(3):141-52. doi: 10.1097/00004850-200015030-00003. Int Clin Psychopharmacol. 2000. PMID: 10870872 Clinical Trial.
During week 1, sleep latency was significantly shorter with zaleplon 5, 10, and 20 mg compared to placebo. The significant decrease in sleep latency persisted through week 4 with zaleplon 20 mg, and was again evident with zaleplon 10 mg at week 3. Zaleplon
During week 1, sleep latency was significantly shorter with zaleplon 5, 10, and 20 mg compared to placebo. The significant decrease i …
Sleep and residual sedation after administration of zaleplon, zolpidem, and placebo during experimental middle-of-the-night awakening.
Zammit GK, Corser B, Doghramji K, Fry JM, James S, Krystal A, Mangano RM. Zammit GK, et al. J Clin Sleep Med. 2006 Oct 15;2(4):417-23. J Clin Sleep Med. 2006. PMID: 17557470 Clinical Trial.
Residual sedation was not detected as little as 4 hours after zaleplon 10 mg, whereas residual sedation was detected with zolpidem 10 mg up to 7 hours after treatment. These findings suggest that zaleplon may be an appropriate treatment for use when patients awaken …
Residual sedation was not detected as little as 4 hours after zaleplon 10 mg, whereas residual sedation was detected with zolpidem 10 …
Comparison of the effects of zaleplon, zolpidem, and triazolam on memory, learning, and psychomotor performance.
Troy SM, Lucki I, Unruh MA, Cevallos WH, Leister CA, Martin PT, Furlan PM, Mangano R. Troy SM, et al. J Clin Psychopharmacol. 2000 Jun;20(3):328-37. doi: 10.1097/00004714-200006000-00007. J Clin Psychopharmacol. 2000. PMID: 10831020 Clinical Trial.
Twenty-four healthy male and female subjects, who participated in this randomized, double-blind, crossover study, received single nighttime doses of zaleplon 10 mg (therapeutic dose), zaleplon 20 mg, zolpidem 10 mg (therapeutic dose), zolpidem 20 mg, triazolam 0.25 …
Twenty-four healthy male and female subjects, who participated in this randomized, double-blind, crossover study, received single nighttime …
47 results