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Page 1
Overview of Inherited Zinc Deficiency in Infants and Children.
Kambe T, Fukue K, Ishida R, Miyazaki S. Kambe T, et al. J Nutr Sci Vitaminol (Tokyo). 2015;61 Suppl:S44-6. doi: 10.3177/jnsv.61.S44. J Nutr Sci Vitaminol (Tokyo). 2015. PMID: 26598882 Free article. Review.
Recent molecular genetic studies have identified responsible genes for two inherited zinc deficiency disorders, acrodermatitis enteropathica (AE) and transient neonatal zinc deficiency (TNZD), clarifying the pathological mechanisms. ...AE is an autosom …
Recent molecular genetic studies have identified responsible genes for two inherited zinc deficiency disorders, acrodermatitis entero …
An update on mutations of the SLC39A4 gene in acrodermatitis enteropathica.
Schmitt S, Küry S, Giraud M, Dréno B, Kharfi M, Bézieau S. Schmitt S, et al. Hum Mutat. 2009 Jun;30(6):926-33. doi: 10.1002/humu.20988. Hum Mutat. 2009. PMID: 19370757 Review.
Acrodermatitis enteropathica (AE) is a very rare inherited recessive disease caused by severe zinc deficiency. It typically occurs in early infancy and is characterized by periorificial and acral dermatitis, alopecia, and diarrhea. ...The SLC39A4 gene encodes a z …
Acrodermatitis enteropathica (AE) is a very rare inherited recessive disease caused by severe zinc deficiency. It typically oc …
Research progress on the molecular structure, function, and application in tumor therapy of zinc transporter ZIP4.
Guo H, Wang S, Zhang H, Li J, Wang C, Liu Z, Chen J, Wang K, Wei X, Wei Q, Xu X. Guo H, et al. Int J Biol Sci. 2024 Nov 4;20(15):5910-5924. doi: 10.7150/ijbs.102460. eCollection 2024. Int J Biol Sci. 2024. PMID: 39664563 Free PMC article. Review.
ZIP4, a pivotal member of the ZIP family, is the causative gene for the hereditary disorder AE (acrodermatitis enteropathica) in humans, and plays an essential role in regulating zinc ion balance within cells. ...Currently, there are two hypotheses concerning the tr …
ZIP4, a pivotal member of the ZIP family, is the causative gene for the hereditary disorder AE (acrodermatitis enteropathica) in huma …
Zinc transporter mutations linked to acrodermatitis enteropathica disrupt function and cause mistrafficking.
Kuliyev E, Zhang C, Sui D, Hu J. Kuliyev E, et al. J Biol Chem. 2021 Jan-Jun;296:100269. doi: 10.1016/j.jbc.2021.100269. Epub 2021 Jan 8. J Biol Chem. 2021. PMID: 33837739 Free PMC article.
ZIP4 is a representative member of the Zrt-/Irt-like protein (ZIP) transporter family and responsible for zinc uptake from diet. Loss-of-function mutations of human ZIP4 (hZIP4) drastically reduce zinc absorption, causing a life-threatening autosomal recessive disor …
ZIP4 is a representative member of the Zrt-/Irt-like protein (ZIP) transporter family and responsible for zinc uptake from diet. Loss …
Genetic causes and gene-nutrient interactions in mammalian zinc deficiencies: acrodermatitis enteropathica and transient neonatal zinc deficiency as examples.
Kasana S, Din J, Maret W. Kasana S, et al. J Trace Elem Med Biol. 2015 Jan;29:47-62. doi: 10.1016/j.jtemb.2014.10.003. J Trace Elem Med Biol. 2015. PMID: 25468189 Review.
One is ZIP4, which is involved in intestinal zinc uptake. Its mutations can cause acrodermatitis enteropathica (AE) with autosomal recessive inheritance. ...The two diseases can be distinguished in affected infants. AE is fatal if zinc is not supplied …
One is ZIP4, which is involved in intestinal zinc uptake. Its mutations can cause acrodermatitis enteropathica (AE) with autos …
Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings.
Chim SM, Howell K, Dronzek J, Wu W, Van Hout C, Ferreira MAR, Ye B, Li A, Brydges S, Arunachalam V, Marcketta A, Locke AE, Bovijn J, Verweij N, De T, Lotta L, Mitnaul L, LeBlanc M, Center RG, Carey DJ, Melander O, Shuldiner A, Karalis K, Economides AN, Nistala H; DiscovEHR collaboration; Regeneron Genetics Center. Chim SM, et al. Elife. 2024 Dec 13;12:RP90419. doi: 10.7554/eLife.90419. Elife. 2024. PMID: 39671241 Free PMC article.
Recent studies have revealed a role for zinc in insulin secretion and glucose homeostasis. Randomized placebo-controlled zinc supplementation trials have demonstrated improved glycemic traits in patients with type II diabetes (T2D). ...These improvements result from …
Recent studies have revealed a role for zinc in insulin secretion and glucose homeostasis. Randomized placebo-controlled zinc …
Heterologous Expression of Full-Length and Truncated Human ZIP4 Zinc Transporter in Saccharomyces cerevisiae.
Liu Y, Bafaro EM, Dempski RE. Liu Y, et al. Biomolecules. 2022 May 21;12(5):726. doi: 10.3390/biom12050726. Biomolecules. 2022. PMID: 35625653 Free PMC article.
Dysfunction of hZIP4 can result in the Zn(2+) deficiency disease acrodermatitis enteropathica (AE). AE can disrupt digestive and immune system homeostasis. A limited number of hZIP4 expression strategies have hindered increasing knowledge about this essential transm …
Dysfunction of hZIP4 can result in the Zn(2+) deficiency disease acrodermatitis enteropathica (AE). AE can disrupt digestive a …
Zinc Favors Triple-Negative Breast Cancer's Microenvironment Modulation and Cell Plasticity.
Vogel-González M, Musa-Afaneh D, Rivera Gil P, Vicente R. Vogel-González M, et al. Int J Mol Sci. 2021 Aug 25;22(17):9188. doi: 10.3390/ijms22179188. Int J Mol Sci. 2021. PMID: 34502091 Free PMC article.
Our studies show that BrM2 cells had double the zinc content of MDA-MB-231 cells. Moreover, exploring different metastatic hallmarks, we found that the zinc concentration is especially important in the microenvironment modulation of brain metastatic cells, enhancing …
Our studies show that BrM2 cells had double the zinc content of MDA-MB-231 cells. Moreover, exploring different metastatic hallmarks, …
Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane.
Kim BE, Wang F, Dufner-Beattie J, Andrews GK, Eide DJ, Petris MJ. Kim BE, et al. J Biol Chem. 2004 Feb 6;279(6):4523-30. doi: 10.1074/jbc.M310799200. Epub 2003 Nov 11. J Biol Chem. 2004. PMID: 14612438 Free article.
Zinc is an essential nutrient for all organisms. Its requirement in humans is illustrated dramatically by the genetic disorder acrodermatitis enteropathica (AE). AE is caused by the reduced uptake of dietary zinc by enterocytes, and the ensuing systemi …
Zinc is an essential nutrient for all organisms. Its requirement in humans is illustrated dramatically by the genetic disorder acrode …
Analysis of the relationship between the mutation site of the SLC39A4 gene and acrodermatitis enteropathica by reporting a rare Chinese twin: a case report and review of the literature.
Zhong W, Yang C, Zhu L, Huang YQ, Chen YF. Zhong W, et al. BMC Pediatr. 2020 Jan 27;20(1):34. doi: 10.1186/s12887-020-1942-4. BMC Pediatr. 2020. PMID: 31987033 Free PMC article. Review.
BACKGROUND: Acrodermatitis enteropathica (AE) is a rare autosomal recessive hereditary skin disease caused by mutations in the SLC39A4 gene and is characterized by periorificial dermatitis, alopecia and diarrhoea due to insufficient zinc absorption. ...CASE PRESENTA …
BACKGROUND: Acrodermatitis enteropathica (AE) is a rare autosomal recessive hereditary skin disease caused by mutations in the SLC39A …
40 results