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Page 1
ZNT1 and Zn 2+ control TLR4 and PD-L1 endocytosis in macrophages to improve chemotherapy efficacy against liver tumor.
Yang D, Tian T, Li X, Zhang B, Qi L, Zhang F, Han M, Wang S, Xiao J, Gou Y, Zhang R, Liu Q, Su S, Liu J, Huang X, Gao Q, Hui L, Tang H, Chen Y, Wang H, Wei B. Yang D, et al. Hepatology. 2024 Aug 1;80(2):312-329. doi: 10.1097/HEP.0000000000000629. Epub 2023 Oct 9. Hepatology. 2024. PMID: 37816045
BACKGROUND AND AIMS: HCC is closely associated with inflammation and immune modulation, and combined chemotherapy with other strategies is under extensive investigation to achieve better efficacy. HCC is accompanied by zinc (Zn) deficiency. This study aims to understand ho …
BACKGROUND AND AIMS: HCC is closely associated with inflammation and immune modulation, and combined chemotherapy with other strategies is u …
Synaptic Zinc: An Emerging Player in Parkinson's Disease.
Sikora J, Ouagazzal AM. Sikora J, et al. Int J Mol Sci. 2021 Apr 29;22(9):4724. doi: 10.3390/ijms22094724. Int J Mol Sci. 2021. PMID: 33946908 Free PMC article. Review.
Alterations of zinc homeostasis have long been implicated in Parkinson's disease (PD). Zinc plays a complex role as both deficiency and excess of intracellular zinc levels have been incriminated in the pathophysiology of the disease. ...Overactivation …
Alterations of zinc homeostasis have long been implicated in Parkinson's disease (PD). Zinc plays a complex role as bot …
LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells.
Nabar NR, Heijjer CN, Shi CS, Hwang IY, Ganesan S, Karlsson MCI, Kehrl JH. Nabar NR, et al. Autophagy. 2022 Jan;18(1):204-222. doi: 10.1080/15548627.2021.1954779. Epub 2021 Jul 27. Autophagy. 2022. PMID: 34313548 Free PMC article.
The common pathogenic mutant, LRRK2(G2019S), appears to hijack this pathway.Abbreviations:ADPR: ADP-ribose; AMPK: AMP-activated protein kinase; BMDM: bone marrow-derived macrophage; cADPR: cyclic-ADP-ribose; COR: C-terminal of ROC; CTSD: cathepsin D; ECAR: extracellular acidifica …
The common pathogenic mutant, LRRK2(G2019S), appears to hijack this pathway.Abbreviations:ADPR: ADP-ribose; AMPK: AMP-activated protein kina …
Should evidence of an autolysosomal de-acidification defect in Alzheimer and Parkinson diseases call for caution in prescribing chronic PPI and DMARD?
Giuliano S, Montemagno C, Domdom MA, Teisseire M, Brest P, Klionsky DJ, Hofman P, Pagès G, Mograbi B. Giuliano S, et al. Autophagy. 2023 Oct;19(10):2800-2806. doi: 10.1080/15548627.2023.2214960. Epub 2023 Jul 23. Autophagy. 2023. PMID: 37482676 Free PMC article.
Nearly fifty million older people suffer from neurodegenerative diseases, including Alzheimer (AD) and Parkinson (PD) disease, a global burden expected to triple by 2050. Such an imminent "neurological pandemic" urges the identification of environmental risk factors that a …
Nearly fifty million older people suffer from neurodegenerative diseases, including Alzheimer (AD) and Parkinson (PD) disease, a glob …
Redox stress and metal dys-homeostasis appear as hallmarks of early prion disease pathogenesis in mice.
Spiers JG, Cortina Chen HJ, Barry TL, Bourgognon JM, Steinert JR. Spiers JG, et al. Free Radic Biol Med. 2022 Nov 1;192:182-190. doi: 10.1016/j.freeradbiomed.2022.09.025. Epub 2022 Sep 25. Free Radic Biol Med. 2022. PMID: 36170956 Review.
One major contributory factor is a redox stress challenge during the development of several protein misfolding conditions including Alzheimer's (AD), Parkinson's disease (PD), and less common conditions such as Creutzfeldt Jakob disease (CJD). CJD is caused by misfolding o …
One major contributory factor is a redox stress challenge during the development of several protein misfolding conditions including Alzheime …
Epithelial barrier resistance is increased by the divalent cation zinc in cultured MDCKII epithelial monolayers.
Carr G, Wright JA, Simmons NL. Carr G, et al. J Membr Biol. 2010 Oct;237(2-3):115-23. doi: 10.1007/s00232-010-9312-z. Epub 2010 Nov 6. J Membr Biol. 2010. PMID: 21057779
Topical zinc applications promote wound healing and epithelialization. "Leaky" MDCKII epithelia exposed to apical ZnCl2 (10 mM) showed a time-dependent increase (t (0.5) 22.2 2.7 min) of transepithelial resistance (R (t)) from 82.3 2.4 omega cm2 to 1,551 225.6 omega …
Topical zinc applications promote wound healing and epithelialization. "Leaky" MDCKII epithelia exposed to apical ZnCl2 (10 mM) showe …
Synaptic zinc contributes to motor and cognitive deficits in 6-hydroxydopamine mouse models of Parkinson's disease.
Sikora J, Kieffer BL, Paoletti P, Ouagazzal AM. Sikora J, et al. Neurobiol Dis. 2020 Feb;134:104681. doi: 10.1016/j.nbd.2019.104681. Epub 2019 Nov 20. Neurobiol Dis. 2020. PMID: 31759136 Free article.
Hyperactivity of glutamatergic corticostrial pathways is recognized as a key pathophysiological mechanism contributing to development of PD symptoms and dopaminergic neurotoxicity. Subset of corticostriatal projection neurons uses Zn(2+) as a co-transmitter alongside gluta …
Hyperactivity of glutamatergic corticostrial pathways is recognized as a key pathophysiological mechanism contributing to development of …
Reactions of palladium and gold complexes with zinc-thiolate chelates using electrospray mass spectrometry and X-ray diffraction: molecular identification of [Pd(bme-dach)], [Au(bme-dach]+ and [ZnCl(bme-dach)]2Pd.
de Paula QA, Liu Q, Almaraz E, Denny JA, Mangrum JB, Bhuvanesh N, Darensbourg MY, Farrell NP. de Paula QA, et al. Dalton Trans. 2009 Dec 28;(48):10896-903. doi: 10.1039/b917748p. Epub 2009 Nov 17. Dalton Trans. 2009. PMID: 20023920
All reactions investigated in this work gave heteronuclear (Zn-thiolate)-metal products, the predominant species being the trinuclear dithiolate-bridged aggregate {[Zn(bme-dach)](2)M}(n+) (M = Pd, Au). X-Ray diffraction studies verified the molecular structure of [{ZnCl(bm …
All reactions investigated in this work gave heteronuclear (Zn-thiolate)-metal products, the predominant species being the trinuclear dithio …
Parkinson's disease-associated human ATP13A2 (PARK9) deficiency causes zinc dyshomeostasis and mitochondrial dysfunction.
Park JS, Koentjoro B, Veivers D, Mackay-Sim A, Sue CM. Park JS, et al. Hum Mol Genet. 2014 Jun 1;23(11):2802-15. doi: 10.1093/hmg/ddt623. Epub 2014 Jan 7. Hum Mol Genet. 2014. PMID: 24399444 Free PMC article.
Accumulation of zinc and mitochondrial dysfunction are established aetiological factors that contribute to PD; however, their underlying molecular mechanisms are largely unknown. ...Taken together, these results indicate that human ATP13A2 deficiency results in z …
Accumulation of zinc and mitochondrial dysfunction are established aetiological factors that contribute to PD; however, their …
Is there a role for Mycobacterium avium subspecies paratuberculosis in Parkinson's disease?
Arru G, Caggiu E, Paulus K, Sechi GP, Mameli G, Sechi LA. Arru G, et al. J Neuroimmunol. 2016 Apr 15;293:86-90. doi: 10.1016/j.jneuroim.2016.02.016. Epub 2016 Feb 27. J Neuroimmunol. 2016. PMID: 27049567
In Parkinson's disease (PD) ZnT proteins play an important role. Zinc is a co-factor of numerous enzymes and stabilizes the tertiary structure of several proteins. ...The hypothesis of cross-reactivity needs to be confirmed; we have observed the presence of MAP in …
In Parkinson's disease (PD) ZnT proteins play an important role. Zinc is a co-factor of numerous enzymes and stabilizes the te …
30 results