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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 1
1954 1
1961 1
1985 1
1986 9
1987 7
1988 20
1989 12
1990 19
1991 24
1992 29
1993 53
1994 50
1995 52
1996 53
1997 67
1998 51
1999 78
2000 73
2001 61
2002 68
2003 64
2004 89
2005 96
2006 118
2007 120
2008 116
2009 119
2010 118
2011 123
2012 114
2013 131
2014 155
2015 132
2016 106
2017 114
2018 124
2019 119
2020 116
2021 116
2022 114
2023 30
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2,784 results
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Page 1
Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis.
De Crescenzo F, D'Alò GL, Ostinelli EG, Ciabattini M, Di Franco V, Watanabe N, Kurtulmus A, Tomlinson A, Mitrova Z, Foti F, Del Giovane C, Quested DJ, Cowen PJ, Barbui C, Amato L, Efthimiou O, Cipriani A. De Crescenzo F, et al. Lancet. 2022 Jul 16;400(10347):170-184. doi: 10.1016/S0140-6736(22)00878-9. Lancet. 2022. PMID: 35843245 Free article.
Benzodiazepines, eszopiclone, zolpidem, and zopiclone were more efficacious than melatonin, ramelteon, and zaleplon (SMD 0.27-0.71 [moderate to very low]). ...For long-term treatment, eszopiclone and lemborexant were more effective than placebo (eszopiclone: SMD 0.63 [95% …
Benzodiazepines, eszopiclone, zolpidem, and zopiclone were more efficacious than melatonin, ramelteon, and zaleplon (SMD 0.27-0.71 [m …
GABA Receptors and the Pharmacology of Sleep.
Wisden W, Yu X, Franks NP. Wisden W, et al. Handb Exp Pharmacol. 2019;253:279-304. doi: 10.1007/164_2017_56. Handb Exp Pharmacol. 2019. PMID: 28993837 Free article.
Pharmacogenetic experiments are leading to an understanding of the circuit mechanisms in the hypothalamus by which zolpidem and similar compounds induce sleep at alpha2betagamma2-type GABA(A) receptors. ...A highly promising sleep-promoting drug, gaboxadol, which activates …
Pharmacogenetic experiments are leading to an understanding of the circuit mechanisms in the hypothalamus by which zolpidem and simil …
Medication induced sleepwalking: A systematic review.
Stallman HM, Kohler M, White J. Stallman HM, et al. Sleep Med Rev. 2018 Feb;37:105-113. doi: 10.1016/j.smrv.2017.01.005. Epub 2017 Jan 29. Sleep Med Rev. 2018. PMID: 28363449 Review.
The strongest evidence for medication-induced sleepwalking was for zolpidem and sodium oxybate. All other associations were based on case reports. ...
The strongest evidence for medication-induced sleepwalking was for zolpidem and sodium oxybate. All other associations were based on …
The effect of zolpidem on memory consolidation over a night of sleep.
Zhang J, Yetton B, Whitehurst LN, Naji M, Mednick SC. Zhang J, et al. Sleep. 2020 Nov 12;43(11):zsaa084. doi: 10.1093/sleep/zsaa084. Sleep. 2020. PMID: 32330272 Free PMC article. Clinical Trial.
The current study investigated the effect of zolpidem on nighttime sleep and overnight improvement of episodic memories. ...RESULTS: We showed greater memory improvement after a night of sleep with zolpidem, compared to placebo, replicating a prior nap study. Additi …
The current study investigated the effect of zolpidem on nighttime sleep and overnight improvement of episodic memories. ...RESULTS: …
Comparison of Lemborexant With Placebo and Zolpidem Tartrate Extended Release for the Treatment of Older Adults With Insomnia Disorder: A Phase 3 Randomized Clinical Trial.
Rosenberg R, Murphy P, Zammit G, Mayleben D, Kumar D, Dhadda S, Filippov G, LoPresti A, Moline M. Rosenberg R, et al. JAMA Netw Open. 2019 Dec 2;2(12):e1918254. doi: 10.1001/jamanetworkopen.2019.18254. JAMA Netw Open. 2019. PMID: 31880796 Free PMC article. Clinical Trial.
OBJECTIVE: To compare treatment with the orexin receptor antagonist lemborexant with placebo and zolpidem tartrate extended release in participants with insomnia disorder. ...Six participants (4 in the zolpidem group and 2 in the lemborexant 5 mg group) reported ser …
OBJECTIVE: To compare treatment with the orexin receptor antagonist lemborexant with placebo and zolpidem tartrate extended release i …
On the pathophysiology and treatment of akinetic mutism.
Arnts H, van Erp WS, Lavrijsen JCM, van Gaal S, Groenewegen HJ, van den Munckhof P. Arnts H, et al. Neurosci Biobehav Rev. 2020 May;112:270-278. doi: 10.1016/j.neubiorev.2020.02.006. Epub 2020 Feb 7. Neurosci Biobehav Rev. 2020. PMID: 32044373 Free article. Review.
Zolpidem-Associated Consequences: An Updated Literature Review With Case Reports.
Westermeyer J, Carr TM. Westermeyer J, et al. J Nerv Ment Dis. 2020 Jan;208(1):28-32. doi: 10.1097/NMD.0000000000001074. J Nerv Ment Dis. 2020. PMID: 31834190 Review.
A post-2000 literature search reviewed prevalence of health consequences associated with zolpidem, plus two salient case reports. Common zolpidem-related harms encompassed accidents, falls, overdoses, delirium, and infections. Risks to others included assaults, vehi …
A post-2000 literature search reviewed prevalence of health consequences associated with zolpidem, plus two salient case reports. Com …
Zolpidem for the Treatment of Neurologic Disorders: A Systematic Review.
Bomalaski MN, Claflin ES, Townsend W, Peterson MD. Bomalaski MN, et al. JAMA Neurol. 2017 Sep 1;74(9):1130-1139. doi: 10.1001/jamaneurol.2017.1133. JAMA Neurol. 2017. PMID: 28655027 Review.
IMPORTANCE: Given its selective action on the omega1 subtype of the gamma-aminobutyric acid A receptor, zolpidem tartrate presents a potential treatment mechanism for other neurologic disorders. OBJECTIVE: To synthesize studies that used zolpidem to treat neurologic …
IMPORTANCE: Given its selective action on the omega1 subtype of the gamma-aminobutyric acid A receptor, zolpidem tartrate presents a …
Efficacy and safety of Zolpidem in the treatment of insomnia disorder for one month: a meta-analysis of a randomized controlled trial.
Xiang T, Cai Y, Hong Z, Pan J. Xiang T, et al. Sleep Med. 2021 Nov;87:250-256. doi: 10.1016/j.sleep.2021.09.005. Epub 2021 Sep 20. Sleep Med. 2021. PMID: 34688027 Free article. Review.
However, when using zolpidem to treat insomnia, its effect on sleep structure should be considered. In the future, large-scale clinical trials are needed to compare the effectiveness and safety of zolpidem in the treatment of insomnia from subjective and objective i …
However, when using zolpidem to treat insomnia, its effect on sleep structure should be considered. In the future, large-scale clinic …
Comparative effectiveness and safety of pharmacological and non-pharmacological interventions for insomnia: an overview of reviews.
Rios P, Cardoso R, Morra D, Nincic V, Goodarzi Z, Farah B, Harricharan S, Morin CM, Leech J, Straus SE, Tricco AC. Rios P, et al. Syst Rev. 2019 Nov 15;8(1):281. doi: 10.1186/s13643-019-1163-9. Syst Rev. 2019. PMID: 31730011 Free PMC article. Review.
Consistent evidence of effectiveness across multiple outcomes based on more than one high- or moderate quality review with meta-analysis was found for zolpidem, suvorexant, doxepin, melatonin, and cognitive behavioral therapy (CBT), and evidence of effectiveness across mul …
Consistent evidence of effectiveness across multiple outcomes based on more than one high- or moderate quality review with meta-analysis was …
2,784 results