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1999 11
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2002 7
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2007 12
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2009 20
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399 results

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Page 1
Comparison of Lemborexant With Placebo and Zolpidem Tartrate Extended Release for the Treatment of Older Adults With Insomnia Disorder: A Phase 3 Randomized Clinical Trial.
Rosenberg R, Murphy P, Zammit G, Mayleben D, Kumar D, Dhadda S, Filippov G, LoPresti A, Moline M. Rosenberg R, et al. JAMA Netw Open. 2019 Dec 2;2(12):e1918254. doi: 10.1001/jamanetworkopen.2019.18254. JAMA Netw Open. 2019. PMID: 31880796 Free PMC article. Clinical Trial.
INTERVENTIONS: Participants received placebo, zolpidem tartrate extended release (6.25 mg), or lemborexant (5 mg or 10 mg) for 1 month at bedtime. ...Six participants (4 in the zolpidem group and 2 in the lemborexant 5 mg group) reported serious adverse events; none …
INTERVENTIONS: Participants received placebo, zolpidem tartrate extended release (6.25 mg), or lemborexant (5 mg or 10 mg) for 1 mont …
Effect of Psychological and Medication Therapies for Insomnia on Daytime Functions: A Randomized Clinical Trial.
Morin CM, Chen SJ, Ivers H, Beaulieu-Bonneau S, Krystal AD, Guay B, Bélanger L, Cartwright A, Simmons B, Lamy M, Busby M, Edinger JD. Morin CM, et al. JAMA Netw Open. 2023 Dec 1;6(12):e2349638. doi: 10.1001/jamanetworkopen.2023.49638. JAMA Netw Open. 2023. PMID: 38153735 Free PMC article. Clinical Trial.
INTERVENTIONS: Participants were randomly assigned to either BT or zolpidem as first-stage therapy, and those whose insomnia had not remitted received a second-stage psychological therapy (BT or cognitive therapy) or medication therapy (zolpidem or trazodone). ...Se …
INTERVENTIONS: Participants were randomly assigned to either BT or zolpidem as first-stage therapy, and those whose insomnia had not …
The effect of zolpidem on memory consolidation over a night of sleep.
Zhang J, Yetton B, Whitehurst LN, Naji M, Mednick SC. Zhang J, et al. Sleep. 2020 Nov 12;43(11):zsaa084. doi: 10.1093/sleep/zsaa084. Sleep. 2020. PMID: 32330272 Free PMC article. Clinical Trial.
The current study investigated the effect of zolpidem on nighttime sleep and overnight improvement of episodic memories. METHODS: We used a double-blind, placebo-controlled within-subject design to test the a priori hypothesis that zolpidem would lead to increased m …
The current study investigated the effect of zolpidem on nighttime sleep and overnight improvement of episodic memories. METHODS: We …
Daridorexant, a New Dual Orexin Receptor Antagonist to Treat Insomnia Disorder.
Dauvilliers Y, Zammit G, Fietze I, Mayleben D, Seboek Kinter D, Pain S, Hedner J. Dauvilliers Y, et al. Ann Neurol. 2020 Mar;87(3):347-356. doi: 10.1002/ana.25680. Epub 2020 Feb 5. Ann Neurol. 2020. PMID: 31953863 Clinical Trial.
METHODS: Adults (64 years) with insomnia disorder were randomized (1:1:1:1:1:1) to receive daily oral placebo, daridorexant (5, 10, 25, or 50mg), or 10mg zolpidem for 30 days. The primary efficacy outcome was the change in wake time after sleep onset from baseline to days …
METHODS: Adults (64 years) with insomnia disorder were randomized (1:1:1:1:1:1) to receive daily oral placebo, daridorexant (5, 10, 25, or 5 …
Number, Duration, and Distribution of Wake Bouts in Patients with Insomnia Disorder: Effect of Daridorexant and Zolpidem.
Di Marco T, Scammell TE, Meinel M, Seboek Kinter D, Datta AN, Zammit G, Dauvilliers Y. Di Marco T, et al. CNS Drugs. 2023 Jul;37(7):639-653. doi: 10.1007/s40263-023-01020-9. Epub 2023 Jul 21. CNS Drugs. 2023. PMID: 37477771 Free PMC article. Clinical Trial.
METHODS: Adults with insomnia disorder were randomized 1:1:1:1:1:1 to placebo, zolpidem 10 mg, or daridorexant 5, 10, 25, or 50 mg in a phase II dose-finding study, and 1:1:1 to placebo or daridorexant 25 or 50 mg in a pivotal phase III study. ...RESULTS: Data from 1111 pa …
METHODS: Adults with insomnia disorder were randomized 1:1:1:1:1:1 to placebo, zolpidem 10 mg, or daridorexant 5, 10, 25, or 50 mg in …
Zolpidem extended-release.
Moen MD, Plosker GL. Moen MD, et al. CNS Drugs. 2006;20(5):419-26; discussion 427-8. doi: 10.2165/00023210-200620050-00006. CNS Drugs. 2006. PMID: 16696581 Clinical Trial.
Zolpidem extended-release, or controlled-release (CR), is a new formulation of zolpidem, a nonbenzodiazepine hypnotic. It is indicated in the US for the treatment of insomnia, characterised by difficulties with sleep onset and/or sleep maintenance. Zolpidem C
Zolpidem extended-release, or controlled-release (CR), is a new formulation of zolpidem, a nonbenzodiazepine hypnotic. It is i
Blinding and bias in a hypnotic clinical trial.
McCall WV, Benca RM, Rumble ME, Krystal AD. McCall WV, et al. Hum Psychopharmacol. 2021 Jan;36(1):1-5. doi: 10.1002/hup.2757. Epub 2020 Sep 11. Hum Psychopharmacol. 2021. PMID: 32918323 Clinical Trial.
METHODS: REST-IT, a, 8-week double-blind RCT, compared zolpidem extended-release (ER) versus placebo at bedtime in 103 adults with major depressive disorder with insomnia and suicidal ideation, and who received open label selective serotonin reuptake inhibitors. ...CONCLUS …
METHODS: REST-IT, a, 8-week double-blind RCT, compared zolpidem extended-release (ER) versus placebo at bedtime in 103 adults with ma …
Randomized controlled trial of zolpidem as a pharmacotherapy for cannabis use disorder.
Lee DC, Schlienz NJ, Herrmann ES, Martin EL, Leoutsakos J, Budney AJ, Smith MT, Tompkins DA, Hampson AJ, Vandrey R. Lee DC, et al. J Subst Use Addict Treat. 2024 Jan;156:209180. doi: 10.1016/j.josat.2023.209180. Epub 2023 Oct 5. J Subst Use Addict Treat. 2024. PMID: 37802317 Clinical Trial.
METHOD: The study enrolled 127 adults seeking treatment for CUD in a 12-week clinical trial and randomized to receive extended-release zolpidem (zolpidem-XR) or placebo. All participants received computerized behavioral therapy and abstinence-based contingency manag …
METHOD: The study enrolled 127 adults seeking treatment for CUD in a 12-week clinical trial and randomized to receive extended-release zo
Randomised clinical trial of the effects of prolonged-release melatonin, temazepam and zolpidem on slow-wave activity during sleep in healthy people.
Arbon EL, Knurowska M, Dijk DJ. Arbon EL, et al. J Psychopharmacol. 2015 Jul;29(7):764-76. doi: 10.1177/0269881115581963. Epub 2015 Apr 28. J Psychopharmacol. 2015. PMID: 25922426 Clinical Trial.
The effects of single oral doses of prolonged-release melatonin, temazepam and zolpidem on EEG slow-wave activity (SWA, 0.75-4.5 Hz) and other frequencies during nocturnal non-rapid eye movement (NREM) sleep were compared. ...These data show that the effects of prolonged-r …
The effects of single oral doses of prolonged-release melatonin, temazepam and zolpidem on EEG slow-wave activity (SWA, 0.75-4.5 Hz) …
Sublingual and oral zolpidem for insomnia disorder: a 3-month randomized trial.
Castro LS, Otuyama LJ, Fumo-Dos-Santos C, Tufik S, Poyares D. Castro LS, et al. Braz J Psychiatry. 2020 Apr;42(2):175-184. doi: 10.1590/1516-4446-2019-0389. Epub 2019 Dec 20. Braz J Psychiatry. 2020. PMID: 31859791 Free PMC article. Clinical Trial.
METHODS: Participants were randomized into an oral group (oral zolpidem 10 mg and sublingual placebo at bedtime and "as-needed") and a sublingual group (oral placebo and sublingual zolpidem 5 mg at bedtime and "as-needed"). ...CONCLUSIONS: The safety and efficacy of …
METHODS: Participants were randomized into an oral group (oral zolpidem 10 mg and sublingual placebo at bedtime and "as-needed") and …
399 results