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PK-PD integration and PK-PD modelling of nonsteroidal anti-inflammatory drugs: principles and applications in veterinary pharmacology.
Lees P, Giraudel J, Landoni MF, Toutain PL. Lees P, et al. J Vet Pharmacol Ther. 2004 Dec;27(6):491-502. doi: 10.1111/j.1365-2885.2004.00618.x. J Vet Pharmacol Ther. 2004. PMID: 15601443 Review.
The principles underlying and uses of PK-PD integration are illustrated in this review for phenylbutazone in the horse and cow, carprofen and meloxicam in the horse, carprofen and meloxicam in the cat and nimesulide in the dog. In the PK-PD modelling a …
The principles underlying and uses of PK-PD integration are illustrated in this review for phenylbutazone in the horse and cow, ca …
Carprofen pharmacokinetics in plasma and in control and inflamed canine tissue fluid using in vivo ultrafiltration.
Messenger KM, Wofford JA, Papich MG. Messenger KM, et al. J Vet Pharmacol Ther. 2016 Feb;39(1):32-9. doi: 10.1111/jvp.12233. Epub 2015 May 10. J Vet Pharmacol Ther. 2016. PMID: 25958925
Measurement of unbound drug concentrations at their sites of action is necessary for accurate PK/PD modeling. The objective of this study was to determine the unbound concentration of carprofen in canine interstitial fluid (ISF) using in vivo ultrafiltration and to …
Measurement of unbound drug concentrations at their sites of action is necessary for accurate PK/PD modeling. The objective of this s …
Pharmacokinetic-pharmacodynamic integration and modelling of oxytetracycline administered alone and in combination with carprofen in calves.
Brentnall C, Cheng Z, McKellar QA, Lees P. Brentnall C, et al. Res Vet Sci. 2013 Jun;94(3):687-94. doi: 10.1016/j.rvsc.2013.01.012. Epub 2013 Feb 14. Res Vet Sci. 2013. PMID: 23415880
The pharmacokinetic (PK) and pharmacodynamic (PD) profiles of oxytetracycline were investigated, when administered both alone and in the presence of carprofen, in healthy calves. ...Similar findings were obtained when oxytetracycline was administered in the presence …
The pharmacokinetic (PK) and pharmacodynamic (PD) profiles of oxytetracycline were investigated, when administered both alone and in …
Pharmacodynamics of oxytetracycline administered alone and in combination with carprofen in calves.
Brentnall C, Cheng Z, McKellar QA, Lees P. Brentnall C, et al. Vet Rec. 2012 Sep 15;171(11):273. doi: 10.1136/vr.100935. Epub 2012 Jul 28. Vet Rec. 2012. PMID: 22843613
The pharmacodynamics (PD) of oxytetracycline was investigated against a strain of Mannheimia haemolytica. In vitro measurements, comprising minimum inhibitory concentration (MIC), minimum bactericidal concentration and time-kill curves, were conducted in five matrices; Mue …
The pharmacodynamics (PD) of oxytetracycline was investigated against a strain of Mannheimia haemolytica. In vitro measurements, comp …
Transferrin-Modified Carprofen Platinum(IV) Nanoparticles as Antimetastasis Agents with Tumor Targeting, Inflammation Inhibition, Epithelial-Mesenchymal Transition Suppression, and Immune Activation Properties.
Zhang M, Chen Y, Feng S, He Y, Liu Z, Zhang N, Wang Q. Zhang M, et al. J Med Chem. 2024 Sep 26;67(18):16416-16434. doi: 10.1021/acs.jmedchem.4c01265. Epub 2024 Sep 5. J Med Chem. 2024. PMID: 39235464
The inflammatory microenvironment is a central driver of tumor metastasis, intimately associated with the promotion of epithelial-mesenchymal transition (EMT) and immune suppression. Here, transferrin-modified carprofen platinum(IV) nanoparticles Tf-NPs@CPF(2)-Pt(IV) with …
The inflammatory microenvironment is a central driver of tumor metastasis, intimately associated with the promotion of epithelial-mesenchyma …
The use of carprofen, a non-steroidal antiinflammatory agent, in peptic ulcer diseases.
Konturek SJ, Kwiecień N, Obtulowicz W, Zmuda A, Polański M, Kopp B, Sito E, Oleksy J. Konturek SJ, et al. Hepatogastroenterology. 1983 Dec;30(6):261-5. Hepatogastroenterology. 1983. PMID: 6676148
The effects of carprofen (Roche), a nonsteroid antiinflammatory agent, on gastric secretion, serum gastrin level, electropotential difference (PD), gastric microbleeding, DNA loss, and the generation of mucosal prostaglandins (PGs) were examined in 20 duodenal ulcer …
The effects of carprofen (Roche), a nonsteroid antiinflammatory agent, on gastric secretion, serum gastrin level, electropotential di …
Nonsteroidal anti-inflammatory drugs and phenols glucuronidation in Caco-2 cells: identification of the UDP-glucuronosyltransferases UGT1A6, 1A3 and 2B7.
Sabolovic N, Magdalou J, Netter P, Abid A. Sabolovic N, et al. Life Sci. 2000;67(2):185-96. doi: 10.1016/s0024-3205(00)00616-0. Life Sci. 2000. PMID: 10901286
Glucuronidation of phenols (1-naphthol, 4-methylumbelliferone) and nonsteroidal anti-inflammatory drugs (NSAIDs) such as ketoprofen, naproxen and carprofen was investigated in human colon carcinoma Caco-2 cell clones. Glucuronidation of these substances was highly effectiv …
Glucuronidation of phenols (1-naphthol, 4-methylumbelliferone) and nonsteroidal anti-inflammatory drugs (NSAIDs) such as ketoprofen, naproxe …