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PK/PD modeling of flunixin meglumine in a kaolin-induced inflammation model in piglets.
Levionnois OL, Fosse TK, Ranheim B. Levionnois OL, et al. J Vet Pharmacol Ther. 2018 Apr;41(2):314-323. doi: 10.1111/jvp.12468. Epub 2017 Nov 16. J Vet Pharmacol Ther. 2018. PMID: 29143334 Clinical Trial.
Flunixin is marketed in several countries for analgesia in adult swine but little is known about its efficacy in piglets. ...Serial venous blood samples were obtained to quantify flunixin in plasma using LC-MS/MS. A PKPD model describing the effect of flunixin …
Flunixin is marketed in several countries for analgesia in adult swine but little is known about its efficacy in piglets. ...Serial v …
PK-PD integration and PK-PD modelling of nonsteroidal anti-inflammatory drugs: principles and applications in veterinary pharmacology.
Lees P, Giraudel J, Landoni MF, Toutain PL. Lees P, et al. J Vet Pharmacol Ther. 2004 Dec;27(6):491-502. doi: 10.1111/j.1365-2885.2004.00618.x. J Vet Pharmacol Ther. 2004. PMID: 15601443 Review.
In the PK-PD modelling approach for NSAIDs, the PK and PD data are generated (usually though not necessarily) in vivo in the same investigation and then modelled in silico, usually using the integrated effect compartment or indirect response models. ...Using indirec …
In the PK-PD modelling approach for NSAIDs, the PK and PD data are generated (usually though not necessarily) in vivo in the s …
Pharmacokinetic/pharmacodynamic modeling of ketoprofen and flunixin at piglet castration and tail-docking.
Nixon E, Chittenden JT, Baynes RE, Messenger KM. Nixon E, et al. J Vet Pharmacol Ther. 2022 Sep;45(5):450-466. doi: 10.1111/jvp.13083. Epub 2022 Jul 14. J Vet Pharmacol Ther. 2022. PMID: 35833463 Free PMC article.
This study performed population-pharmacokinetic/pharmacodynamic (pop-PK/PD) modeling of ketoprofen and flunixin in piglets undergoing routine castration and tail-docking, utilizing previously published data. ...Given this information, flunixin may be the best …
This study performed population-pharmacokinetic/pharmacodynamic (pop-PK/PD) modeling of ketoprofen and flunixin in piglets und …
Comparison of the anti-inflammatory actions of flunixin and ketoprofen in horses applying PK/PD modelling.
Landoni MF, Lees P. Landoni MF, et al. Equine Vet J. 1995 Jul;27(4):247-56. doi: 10.1111/j.2042-3306.1995.tb03073.x. Equine Vet J. 1995. PMID: 8536660
A comparative study in horses of the pharmacokinetics (PK) and pharmacodynamics (PD) of 2 extensively used nonsteroidal anti-inflammatory drugs (NSAIDs), flunixin (FXN) and ketoprofen (KTP), was carried out applying PK/PD modelling. ...However, no differences …
A comparative study in horses of the pharmacokinetics (PK) and pharmacodynamics (PD) of 2 extensively used nonsteroidal anti-inflamma …
Effect of flunixin meglumine on the pharmacokinetics of enrofloxacin and marbofloxacin in preweaning calves.
Pizarro NU, Messina MJ, Prieto G, Post CL, Errecalde C. Pizarro NU, et al. Vet Rec. 2026 Jul 25;199(2):e98-e105. doi: 10.1002/vetr.70473. Epub 2026 Mar 16. Vet Rec. 2026. PMID: 41834571 Free PMC article.
This study evaluated flunixin's effects on these drugs' pharmacokinetics and pharmacokinetic/pharmacodynamic (PK/PD) indices against key bovine respiratory pathogens of clinical relevance. ...PK/PD indices were also calculated. RESULTS: Flunixin meglum …
This study evaluated flunixin's effects on these drugs' pharmacokinetics and pharmacokinetic/pharmacodynamic (PK/PD) indices a …
Evaluation of different PK/PD ratios of three enrofloxacin preparations on the clinical response of pneumonic calves.
Gutiérrez L, Mejía-Arthur I, Posadas-Manzano E, Rodríguez-Becerril N, López-Ordaz R, Sumano H. Gutiérrez L, et al. J Vet Sci. 2025 Jan;26(1):e7. doi: 10.4142/jvs.24161. Epub 2024 Nov 23. J Vet Sci. 2025. PMID: 39749382 Free PMC article.
OBJECTIVE: To correlate the pharmacokinetics/pharmacodynamics (PK/PD) ratios of three pharmaceutical preparations of enrofloxacin with their clinical efficacy in treating BRD. METHODS: The PK/PD ratios of three enrofloxacin preparations were determined in healthy ca …
OBJECTIVE: To correlate the pharmacokinetics/pharmacodynamics (PK/PD) ratios of three pharmaceutical preparations of enrofloxacin wit …
Plasma concentrations and therapeutic efficacy of phenylbutazone and flunixin meglumine in the horse: pharmacokinetic/pharmacodynamic modelling.
Toutain PL, Autefage A, Legrand C, Alvinerie M. Toutain PL, et al. J Vet Pharmacol Ther. 1994 Dec;17(6):459-69. doi: 10.1111/j.1365-2885.1994.tb00278.x. J Vet Pharmacol Ther. 1994. PMID: 7707492
The purpose of the present study was to establish in the horse the relationship between plasma concentration profiles of phenylbutazone (PBZ) and flunixin meglumine (FM) and their pharmacological effects in order to build a predictive pharmacokinetic/pharmacodynamic (PK/ …
The purpose of the present study was to establish in the horse the relationship between plasma concentration profiles of phenylbutazone (PBZ …