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Parkinsonism Attenuation by Antihistamines via Downregulating the Oxidative Stress, Histamine, and Inflammation.
Ayaz M, Anwar F, Saleem U, Shahzadi I, Ahmad B, Mir A, Ismail T. Ayaz M, et al. ACS Omega. 2022 Apr 20;7(17):14772-14783. doi: 10.1021/acsomega.2c00145. eCollection 2022 May 3. ACS Omega. 2022. PMID: 35557705 Free PMC article.
This study was aimed to evaluate the effects of H1 antagonist's ebastine and levocetirizine in PD per se and in combination. Animals were divided into 9 groups (n = 10). ...Group IX was treated with levocetirizine (1 mg/kg) + levo (20 mg/kg). PD was in …
This study was aimed to evaluate the effects of H1 antagonist's ebastine and levocetirizine in PD per se and in combination. A …
Literature-Based Discovery Predicts Antihistamines Are a Promising Repurposed Adjuvant Therapy for Parkinson's Disease.
Tandra G, Yoone A, Mathew R, Wang M, Hales CM, Mitchell CS. Tandra G, et al. Int J Mol Sci. 2023 Aug 2;24(15):12339. doi: 10.3390/ijms241512339. Int J Mol Sci. 2023. PMID: 37569714 Free PMC article.
Cross-domain text mining, hub network analysis, and unsupervised learning rank aggregation were performed in SemNet 2.0 to predict the most relevant drug candidates to levodopa and PD using relevance-based HeteSim scores. The top predicted adjuvant PD therapies incl …
Cross-domain text mining, hub network analysis, and unsupervised learning rank aggregation were performed in SemNet 2.0 to predict the most …
Effect of levocetirizine on the contraction induced by histamine on isolated rabbit bronchioles from precision-cut lung slices.
Simoen V, Christophe B. Simoen V, et al. Pharmacology. 2006;78(2):61-5. doi: 10.1159/000095508. Epub 2006 Aug 30. Pharmacology. 2006. PMID: 16943691
The present experiments were designed to study the effects of levocetirizine (a potent selective histamine H(1) antagonist) on the contraction induced by histamine on isolated rabbit bronchioles using the precision-cut lung slice technology. ...Levocetirizine (0.03- …
The present experiments were designed to study the effects of levocetirizine (a potent selective histamine H(1) antagonist) on the co …
Gateways to clinical trials.
Tomillero A, Moral MA. Tomillero A, et al. Methods Find Exp Clin Pharmacol. 2009 Dec;31(10):661-700. Methods Find Exp Clin Pharmacol. 2009. PMID: 20140276
[Methoxy-(11)C]PD-153035, 2-Methoxyestradiol; Adalimumab, Adecatumumab, Adefovir dipivoxil, ADH-1, ADX-10059, Aflibercept, AIR-human growth hormone, Aliskiren fumarate, AMG-221, Amlodipine besylate/olmesartan medoxomil, Aprepitant; Bavituximab, Bevacizumab, Bexarotene, BIB …
[Methoxy-(11)C]PD-153035, 2-Methoxyestradiol; Adalimumab, Adecatumumab, Adefovir dipivoxil, ADH-1, ADX-10059, Aflibercept, AIR-human …
Contractile properties of various histaprodifen derivatives in guinea pig isolated ileum and trachea.
Christophe B, Carlier B, Schunack W, Chatelain P, Peck M, Massingham R. Christophe B, et al. Pharmacology. 2007;79(2):104-13. doi: 10.1159/000097929. Epub 2006 Dec 12. Pharmacology. 2007. PMID: 17164592
Histamine contracted the trachea faster than histaprodifen derivatives. Levocetirizine antagonized contractions induced by histamine and histaprodifen derivatives in both tissues. The differences observed in the calculated pA(2) (7.60-8.29) and/or pD'(2) values (6.2 …
Histamine contracted the trachea faster than histaprodifen derivatives. Levocetirizine antagonized contractions induced by histamine …