Aim: The current work establishes an easy, reliable technique for the estimation of serum Olanzapine concentration which correlates it clinically.
Subjects and methods: The work was agreed in 61 schizophrenic patients who were on olanzapine. Serum drug amount was estimated by normal-phase high-performance liquid chromatography and brief psychiatry rating scale was used to determine disease progression.
Results: Samples provided 61 patients, 40 were under sub-therapeutic range, 18 were under therapeutic range and 3 were above the therapeutic range.
Conclusion: Therapeutic drug monitoring must be a part of clinical practice in psychiatric hospitals for optimizing the dose of an individual patient along with the correlation of serum concentration with the clinical assessment scales.
Keywords: High-performance liquid chromatography and therapeutic range; olanzapine; schizophrenia; therapeutic drug monitoring.