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A Phase 2a randomized, single-center, double-blind, placebo-controlled study to evaluate the safety and preliminary efficacy of oral iOWH032 against cholera diarrhea in a controlled human infection model.
Erdem R, Ambler G, Al-Ibrahim M, Fraczek K, Dong SD, Gast C, Mercer LD, Raine M, Tennant SM, Chen WH, de Hostos EL, Choy RKM. Erdem R, et al. Among authors: de hostos el. PLoS Negl Trop Dis. 2021 Nov 18;15(11):e0009969. doi: 10.1371/journal.pntd.0009969. eCollection 2021 Nov. PLoS Negl Trop Dis. 2021. PMID: 34793441 Free PMC article. Clinical Trial.
Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei.
Zhang Z, Barros-Álvarez X, Gillespie JR, Ranade RM, Huang W, Shibata S, Molasky NMR, Faghih O, Mushtaq A, Choy RKM, de Hostos E, Hol WGJ, Verlinde CLMJ, Buckner FS, Fan E. Zhang Z, et al. RSC Med Chem. 2020 May 18;11(8):885-895. doi: 10.1039/d0md00057d. eCollection 2020 Aug 1. RSC Med Chem. 2020. PMID: 33479683 Free PMC article.
Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned.
Choi R, Hulverson MA, Huang W, Vidadala RSR, Whitman GR, Barrett LK, Schaefer DA, Betzer DP, Riggs MW, Doggett JS, Hemphill A, Ortega-Mora LM, McCloskey MC, Arnold SLM, Hackman RC, Marsh KC, Lynch JJ, Freiberg GM, Leroy BE, Kempf DJ, Choy RKM, de Hostos EL, Maly DJ, Fan E, Ojo KK, Van Voorhis WC. Choi R, et al. Among authors: de hostos el. Int J Parasitol. 2020 May;50(5):413-422. doi: 10.1016/j.ijpara.2020.01.006. Epub 2020 Mar 26. Int J Parasitol. 2020. PMID: 32224121 Free PMC article. Review.
Spontaneous Selection of Cryptosporidium Drug Resistance in a Calf Model of Infection.
Hasan MM, Stebbins EE, Choy RKM, Gillespie JR, de Hostos EL, Miller P, Mushtaq A, Ranade RM, Teixeira JE, Verlinde CLMJ, Sateriale A, Zhang Z, Osbourn DM, Griggs DW, Fan E, Buckner FS, Huston CD. Hasan MM, et al. Among authors: de hostos el. Antimicrob Agents Chemother. 2021 May 18;65(6):e00023-21. doi: 10.1128/AAC.00023-21. Print 2021 May 18. Antimicrob Agents Chemother. 2021. PMID: 33753338 Free PMC article.
Validation of the Micronutrient and Environmental Enteric Dysfunction Assessment Tool and evaluation of biomarker risk factors for growth faltering and vaccine failure in young Malian children.
Arndt MB, Cantera JL, Mercer LD, Kalnoky M, White HN, Bizilj G, Boyle DS, de Hostos EL, Choy RKM. Arndt MB, et al. Among authors: de hostos el. PLoS Negl Trop Dis. 2020 Sep 30;14(9):e0008711. doi: 10.1371/journal.pntd.0008711. eCollection 2020 Sep. PLoS Negl Trop Dis. 2020. PMID: 32997666 Free PMC article. Clinical Trial.
SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1.
Huang W, Ojo KK, Zhang Z, Rivas K, Vidadala RS, Scheele S, DeRocher AE, Choi R, Hulverson MA, Barrett LK, Bruzual I, Siddaramaiah LK, Kerchner KM, Kurnick MD, Freiberg GM, Kempf D, Hol WG, Merritt EA, Neckermann G, de Hostos EL, Isoherranen N, Maly DJ, Parsons M, Doggett JS, Van Voorhis WC, Fan E. Huang W, et al. Among authors: de hostos el. ACS Med Chem Lett. 2015 Oct 22;6(12):1184-1189. doi: 10.1021/acsmedchemlett.5b00319. eCollection 2015 Dec 10. ACS Med Chem Lett. 2015. PMID: 26693272 Free PMC article.
31 results