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Linking transcription, RNA polymerase II elongation and alternative splicing.
Giono LE, Kornblihtt AR. Giono LE, et al. Biochem J. 2020 Aug 28;477(16):3091-3104. doi: 10.1042/BCJ20200475. Biochem J. 2020. PMID: 32857854 Review.
Similarly, alternative splicing choices are affected by all of these aspects, mainly through the regulation of transcription elongation, making it a regulatory knob on a par with the regulation of gene expression levels. This review aims to recapitulat …
Similarly, alternative splicing choices are affected by all of these aspects, mainly through the regulation of transcriptio
CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing.
Shukla S, Kavak E, Gregory M, Imashimizu M, Shutinoski B, Kashlev M, Oberdoerffer P, Sandberg R, Oberdoerffer S. Shukla S, et al. Nature. 2011 Nov 3;479(7371):74-9. doi: 10.1038/nature10442. Nature. 2011. PMID: 21964334 Free PMC article.
Alternative splicing of pre-messenger RNA is a key feature of transcriptome expansion in eukaryotic cells, yet its regulation is poorly understood. ...Moreover, the rate of transcription elongation has been linked to alternative
Alternative splicing of pre-messenger RNA is a key feature of transcriptome expansion in eukaryotic cells, yet its regu
How slow RNA polymerase II elongation favors alternative exon skipping.
Dujardin G, Lafaille C, de la Mata M, Marasco LE, Muñoz MJ, Le Jossic-Corcos C, Corcos L, Kornblihtt AR. Dujardin G, et al. Mol Cell. 2014 May 22;54(4):683-90. doi: 10.1016/j.molcel.2014.03.044. Epub 2014 May 1. Mol Cell. 2014. PMID: 24793692 Free article.
Splicing is functionally coupled to transcription, linking the rate of RNA polymerase II (Pol II) elongation and the ability of splicing factors to recognize splice sites (ss) of various strengths. In most cases, slow
Splicing is functionally coupled to transcription, linking the rate of RNA polymerase II (Pol I
Transcriptional elongation and alternative splicing.
Dujardin G, Lafaille C, Petrillo E, Buggiano V, Gómez Acuña LI, Fiszbein A, Godoy Herz MA, Nieto Moreno N, Muñoz MJ, Alló M, Schor IE, Kornblihtt AR. Dujardin G, et al. Biochim Biophys Acta. 2013 Jan;1829(1):134-40. doi: 10.1016/j.bbagrm.2012.08.005. Epub 2012 Sep 7. Biochim Biophys Acta. 2013. PMID: 22975042 Review.
We discuss some of the links between transcription and splicing, with special emphasis on the role played by transcription elongation in the regulation of alternative splicing events and in particular the kinetic model of altern
We discuss some of the links between transcription and splicing, with special emphasis on the role played by transcr
Coupling transcription and alternative splicing.
Kornblihtt AR. Kornblihtt AR. Adv Exp Med Biol. 2007;623:175-89. doi: 10.1007/978-0-387-77374-2_11. Adv Exp Med Biol. 2007. PMID: 18380347 Review.
We discuss here the different mechanisms by which transcription regulates alternative splicing. These include the recruitment of splicing factors to the transcribing polymerase and "kinetic coupling", which involves changes in the rate of tra
We discuss here the different mechanisms by which transcription regulates alternative splicing. These include the recru …
The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations.
Chen L, Chen JY, Huang YJ, Gu Y, Qiu J, Qian H, Shao C, Zhang X, Hu J, Li H, He S, Zhou Y, Abdel-Wahab O, Zhang DE, Fu XD. Chen L, et al. Mol Cell. 2018 Feb 1;69(3):412-425.e6. doi: 10.1016/j.molcel.2017.12.029. Epub 2018 Jan 27. Mol Cell. 2018. PMID: 29395063 Free PMC article.
Mutations in several general pre-mRNA splicing factors have been linked to myelodysplastic syndromes (MDSs) and solid tumors. ...We further demonstrate that enhanced R-loops, opposite to the expectation from gained RNA binding with mutant SRSF2, result from i …
Mutations in several general pre-mRNA splicing factors have been linked to myelodysplastic syndromes (MDSs) and solid tumors. …
A saga of cancer epigenetics: linking epigenetics to alternative splicing.
Narayanan SP, Singh S, Shukla S. Narayanan SP, et al. Biochem J. 2017 Mar 7;474(6):885-896. doi: 10.1042/BCJ20161047. Biochem J. 2017. PMID: 28270561 Review.
It is now well known that several diseases are a direct and indirect consequence of aberrant splicing events in humans. In addition to the conventional mode of alternative splicing regulation by 'cis' RNA-binding sites and 'trans' RNA-binding pr …
It is now well known that several diseases are a direct and indirect consequence of aberrant splicing events in humans. In addition t …
RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20.
de la Mata M, Kornblihtt AR. de la Mata M, et al. Nat Struct Mol Biol. 2006 Nov;13(11):973-80. doi: 10.1038/nsmb1155. Epub 2006 Oct 8. Nat Struct Mol Biol. 2006. PMID: 17028590
Previous studies have linked the C-terminal domain (CTD) of RNA polymerase II (pol II) with cotranscriptional precursor messenger RNA processing, but little is known about the CTD's function in regulating alternative spli
Previous studies have linked the C-terminal domain (CTD) of RNA polymerase II (pol II) with cotranscripti …
Multiple links between transcription and splicing.
Kornblihtt AR, de la Mata M, Fededa JP, Munoz MJ, Nogues G. Kornblihtt AR, et al. RNA. 2004 Oct;10(10):1489-98. doi: 10.1261/rna.7100104. RNA. 2004. PMID: 15383674 Free PMC article. Review.
This review focuses on the roles of cis- and trans-acting factors that regulate transcription, on constitutive and alternative splicing. We also discuss possible functions in splicing of the C-terminal domain (CTD) of the RNA polymerase
This review focuses on the roles of cis- and trans-acting factors that regulate transcription, on constitutive and alternative
Connections between chromatin signatures and splicing.
Gómez Acuña LI, Fiszbein A, Alló M, Schor IE, Kornblihtt AR. Gómez Acuña LI, et al. Wiley Interdiscip Rev RNA. 2013 Jan-Feb;4(1):77-91. doi: 10.1002/wrna.1142. Epub 2012 Oct 16. Wiley Interdiscip Rev RNA. 2013. PMID: 23074139 Review.
Splicing and alternative splicing are involved in the expression of most human genes, playing key roles in differentiation, cell cycle progression, and development. ...These span from regulation of RNA polymerase II elongation, whi
Splicing and alternative splicing are involved in the expression of most human genes, playing key roles in differentiat
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