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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 1
2004 1
2005 1
2006 1
2007 1
2009 1
2011 2
2012 2
2013 2
2014 2
2015 3
2017 1
2018 2
2020 1
2021 2
2022 1
2023 3
2024 0

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24 results

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Page 1
Linking transcription, RNA polymerase II elongation and alternative splicing.
Giono LE, Kornblihtt AR. Giono LE, et al. Biochem J. 2020 Aug 28;477(16):3091-3104. doi: 10.1042/BCJ20200475. Biochem J. 2020. PMID: 32857854 Review.
Similarly, alternative splicing choices are affected by all of these aspects, mainly through the regulation of transcription elongation, making it a regulatory knob on a par with the regulation of gene expression levels. This review aims to recapitulat …
Similarly, alternative splicing choices are affected by all of these aspects, mainly through the regulation of transcriptio …
How slow RNA polymerase II elongation favors alternative exon skipping.
Dujardin G, Lafaille C, de la Mata M, Marasco LE, Muñoz MJ, Le Jossic-Corcos C, Corcos L, Kornblihtt AR. Dujardin G, et al. Mol Cell. 2014 May 22;54(4):683-90. doi: 10.1016/j.molcel.2014.03.044. Epub 2014 May 1. Mol Cell. 2014. PMID: 24793692 Free article.
Splicing is functionally coupled to transcription, linking the rate of RNA polymerase II (Pol II) elongation and the ability of splicing factors to recognize splice sites (ss) of various strengths. In most cases, slow …
Splicing is functionally coupled to transcription, linking the rate of RNA polymerase II (Pol I …
Transcriptional elongation and alternative splicing.
Dujardin G, Lafaille C, Petrillo E, Buggiano V, Gómez Acuña LI, Fiszbein A, Godoy Herz MA, Nieto Moreno N, Muñoz MJ, Alló M, Schor IE, Kornblihtt AR. Dujardin G, et al. Biochim Biophys Acta. 2013 Jan;1829(1):134-40. doi: 10.1016/j.bbagrm.2012.08.005. Epub 2012 Sep 7. Biochim Biophys Acta. 2013. PMID: 22975042 Review.
We discuss some of the links between transcription and splicing, with special emphasis on the role played by transcription elongation in the regulation of alternative splicing events and in particular the kinetic model of altern …
We discuss some of the links between transcription and splicing, with special emphasis on the role played by transcr …
RNA polymerase II-associated proteins reveal pathways affected in VCP-related amyotrophic lateral sclerosis.
Rafiee MR, Rohban S, Davey K, Ule J, Luscombe NM. Rafiee MR, et al. Brain. 2023 Jun 1;146(6):2547-2556. doi: 10.1093/brain/awad046. Brain. 2023. PMID: 36789492 Free PMC article.
Moreover, VCP mediates UV-induced proteolysis of RNA polymerase II (RNAPII), but little is known about the effects of VCP mutations on the transcriptional machinery. ...Together, these findings shed light on how transcription and splicing …
Moreover, VCP mediates UV-induced proteolysis of RNA polymerase II (RNAPII), but little is known about the effects of V …
Emerging roles of BET proteins in transcription and co-transcriptional RNA processing.
Eischer N, Arnold M, Mayer A. Eischer N, et al. Wiley Interdiscip Rev RNA. 2023 Jan;14(1):e1734. doi: 10.1002/wrna.1734. Epub 2022 May 1. Wiley Interdiscip Rev RNA. 2023. PMID: 35491403 Review.
Transcription by RNA polymerase II (Pol II) gives rise to all nuclear protein-coding and a large set of non-coding RNAs, and is strictly regulated and coordinated with RNA processing. ...Finally, we propose an updated model for the functi …
Transcription by RNA polymerase II (Pol II) gives rise to all nuclear protein-coding and a large set of n …
Elongation roadblocks mediated by dCas9 across human genes modulate transcription and nascent RNA processing.
Zukher I, Dujardin G, Sousa-Luís R, Proudfoot NJ. Zukher I, et al. Nat Struct Mol Biol. 2023 Oct;30(10):1536-1548. doi: 10.1038/s41594-023-01090-9. Epub 2023 Oct 2. Nat Struct Mol Biol. 2023. PMID: 37783853 Free PMC article.
Non-cleaving Cas9 (dCas9) is widely employed to manipulate specific gene loci, often with scant regard for unintended transcriptional effects. We demonstrate here that dCas9 mediates precise RNA polymerase II transcriptional pausing followed by …
Non-cleaving Cas9 (dCas9) is widely employed to manipulate specific gene loci, often with scant regard for unintended transcriptional …
A saga of cancer epigenetics: linking epigenetics to alternative splicing.
Narayanan SP, Singh S, Shukla S. Narayanan SP, et al. Biochem J. 2017 Mar 7;474(6):885-896. doi: 10.1042/BCJ20161047. Biochem J. 2017. PMID: 28270561 Review.
It is now well known that several diseases are a direct and indirect consequence of aberrant splicing events in humans. In addition to the conventional mode of alternative splicing regulation by 'cis' RNA-binding sites and 'trans' RNA-binding pr …
It is now well known that several diseases are a direct and indirect consequence of aberrant splicing events in humans. In addition t …
Coupling transcription and alternative splicing.
Kornblihtt AR. Kornblihtt AR. Adv Exp Med Biol. 2007;623:175-89. doi: 10.1007/978-0-387-77374-2_11. Adv Exp Med Biol. 2007. PMID: 18380347 Review.
We discuss here the different mechanisms by which transcription regulates alternative splicing. These include the recruitment of splicing factors to the transcribing polymerase and "kinetic coupling", which involves changes in the rate of tra …
We discuss here the different mechanisms by which transcription regulates alternative splicing. These include the recru …
RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20.
de la Mata M, Kornblihtt AR. de la Mata M, et al. Nat Struct Mol Biol. 2006 Nov;13(11):973-80. doi: 10.1038/nsmb1155. Epub 2006 Oct 8. Nat Struct Mol Biol. 2006. PMID: 17028590
Previous studies have linked the C-terminal domain (CTD) of RNA polymerase II (pol II) with cotranscriptional precursor messenger RNA processing, but little is known about the CTD's function in regulating alternative splicing …
Previous studies have linked the C-terminal domain (CTD) of RNA polymerase II (pol II) with cotranscripti …
Multiple links between transcription and splicing.
Kornblihtt AR, de la Mata M, Fededa JP, Munoz MJ, Nogues G. Kornblihtt AR, et al. RNA. 2004 Oct;10(10):1489-98. doi: 10.1261/rna.7100104. RNA. 2004. PMID: 15383674 Free PMC article. Review.
This review focuses on the roles of cis- and trans-acting factors that regulate transcription, on constitutive and alternative splicing. We also discuss possible functions in splicing of the C-terminal domain (CTD) of the RNA polymerase …
This review focuses on the roles of cis- and trans-acting factors that regulate transcription, on constitutive and alternative …
24 results