Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 1
1980 2
1981 6
1982 11
1983 13
1984 21
1985 29
1986 75
1987 108
1988 168
1989 210
1990 241
1991 327
1992 430
1993 580
1994 689
1995 840
1996 872
1997 922
1998 1130
1999 1113
2000 1261
2001 1308
2002 1366
2003 1302
2004 1324
2005 1412
2006 1356
2007 1361
2008 1301
2009 1258
2010 1341
2011 1335
2012 1353
2013 1402
2014 1469
2015 1412
2016 1360
2017 1283
2018 1249
2019 1352
2020 1353
2021 1343
2022 1182
2023 1054
2024 162

Text availability

Article attribute

Article type

Publication date

Search Results

36,547 results

Results by year

Citations

6 articles found by citation matching

Search results

Filters applied: . Clear all
Page 1
The physiology of alternative splicing.
Marasco LE, Kornblihtt AR. Marasco LE, et al. Nat Rev Mol Cell Biol. 2023 Apr;24(4):242-254. doi: 10.1038/s41580-022-00545-z. Epub 2022 Oct 13. Nat Rev Mol Cell Biol. 2023. PMID: 36229538 Review.
Alternative splicing is a substantial contributor to the high complexity of transcriptomes of multicellular eukaryotes. ...We also discuss how mastering the control of alternative splicing paved the way to clinically approved therapies for hereditary d
Alternative splicing is a substantial contributor to the high complexity of transcriptomes of multicellular eukaryotes. ...We
The role of alternative splicing in cancer: From oncogenesis to drug resistance.
Sciarrillo R, Wojtuszkiewicz A, Assaraf YG, Jansen G, Kaspers GJL, Giovannetti E, Cloos J. Sciarrillo R, et al. Drug Resist Updat. 2020 Dec;53:100728. doi: 10.1016/j.drup.2020.100728. Epub 2020 Sep 28. Drug Resist Updat. 2020. PMID: 33070093 Free article. Review.
Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-mRNA are removed and protein-coding segments are assembled in diverse combinations, ultimately giving rise to proteins with distinct or even opposing functions. ...Consequently,
Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-mRNA are removed and protein-coding se
Alternative splicing as a regulator of development and tissue identity.
Baralle FE, Giudice J. Baralle FE, et al. Nat Rev Mol Cell Biol. 2017 Jul;18(7):437-451. doi: 10.1038/nrm.2017.27. Epub 2017 May 10. Nat Rev Mol Cell Biol. 2017. PMID: 28488700 Free PMC article. Review.
Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate vast protein diversity from a limited number of genes. The mechanisms and outcomes of alternative splicing of individual transcripts are relatively well unders
Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate vast protein diversity from a lim
Alternative Splicing Regulatory Networks: Functions, Mechanisms, and Evolution.
Ule J, Blencowe BJ. Ule J, et al. Mol Cell. 2019 Oct 17;76(2):329-345. doi: 10.1016/j.molcel.2019.09.017. Mol Cell. 2019. PMID: 31626751 Free article. Review.
High-throughput sequencing-based methods and their applications in the study of transcriptomes have revolutionized our understanding of alternative splicing. Networks of functionally coordinated and biologically important alternative splicing events co …
High-throughput sequencing-based methods and their applications in the study of transcriptomes have revolutionized our understanding of a
Use of splicing reporter minigene assay to evaluate the effect on splicing of unclassified genetic variants.
Gaildrat P, Killian A, Martins A, Tournier I, Frébourg T, Tosi M. Gaildrat P, et al. Methods Mol Biol. 2010;653:249-57. doi: 10.1007/978-1-60761-759-4_15. Methods Mol Biol. 2010. PMID: 20721748 Review.
A fraction of UVs may be deleterious because they affect mRNA splicing. Here, we describe a functional splicing assay based on a minigene construct that assesses the impact of sequence variants on splicing. ...This method represents a complementary approach t …
A fraction of UVs may be deleterious because they affect mRNA splicing. Here, we describe a functional splicing assay based on …
The neurogenetics of alternative splicing.
Vuong CK, Black DL, Zheng S. Vuong CK, et al. Nat Rev Neurosci. 2016 May;17(5):265-81. doi: 10.1038/nrn.2016.27. Nat Rev Neurosci. 2016. PMID: 27094079 Free PMC article. Review.
Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in mammals and is controlled by specialized RNA-binding proteins. The misregulation of splicing is implicated in multiple neurological disorders. We describe recent mouse ge
Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in mammals and is controlled by speciali
Aberrant alternative splicing in breast cancer.
Yang Q, Zhao J, Zhang W, Chen D, Wang Y. Yang Q, et al. J Mol Cell Biol. 2019 Oct 25;11(10):920-929. doi: 10.1093/jmcb/mjz033. J Mol Cell Biol. 2019. PMID: 31065692 Free PMC article. Review.
Importantly, alternative splicing is a hallmark of cancer and a potential target for cancer therapeutics. ...Here, we seek to provide a general review of the relationship between alternative splicing and breast cancer. We introduce the process of al
Importantly, alternative splicing is a hallmark of cancer and a potential target for cancer therapeutics. ...Here, we seek to …
Alternative RNA Splicing-The Trojan Horse of Cancer Cells in Chemotherapy.
Mehterov N, Kazakova M, Sbirkov Y, Vladimirov B, Belev N, Yaneva G, Todorova K, Hayrabedyan S, Sarafian V. Mehterov N, et al. Genes (Basel). 2021 Jul 18;12(7):1085. doi: 10.3390/genes12071085. Genes (Basel). 2021. PMID: 34356101 Free PMC article. Review.
The resultant gene products might have distinctly different and, in some cases, even opposite functions. Therefore, the abnormal regulation of alternative splicing plays a crucial role in malignant transformation, development, and progression, a fact supported by th …
The resultant gene products might have distinctly different and, in some cases, even opposite functions. Therefore, the abnormal regulation …
Alternative splicing of the metalloprotease ADAMTS17 spacer regulates secretion and modulates autoproteolytic activity.
Balic Z, Misra S, Willard B, Reinhardt DP, Apte SS, Hubmacher D. Balic Z, et al. FASEB J. 2021 Feb;35(2):e21310. doi: 10.1096/fj.202001120RR. FASEB J. 2021. PMID: 33484187 Free PMC article.
Here, we characterize the structural and functional impact of alternative splicing of ADAMTS17, mutations in which cause Weill-Marchesani syndrome 4. ...The second variant, ADAMTS17B, results from an in-frame exon deletion and prevents ADAMTS17B secretion. Thus, …
Here, we characterize the structural and functional impact of alternative splicing of ADAMTS17, mutations in which cause Weill …
Noncoding RNAs regulate alternative splicing in Cancer.
Liu Y, Liu X, Lin C, Jia X, Zhu H, Song J, Zhang Y. Liu Y, et al. J Exp Clin Cancer Res. 2021 Jan 6;40(1):11. doi: 10.1186/s13046-020-01798-2. J Exp Clin Cancer Res. 2021. PMID: 33407694 Free PMC article. Review.
AS (alternative splicing) is a fundamental process by which a gene can generate multiple distinct mRNA transcripts to increase protein diversity. ...
AS (alternative splicing) is a fundamental process by which a gene can generate multiple distinct mRNA transcripts to increase …
36,547 results
You have reached the last available page of results. Please see the User Guide for more information.