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26945548,29504415,25666542,28858018,26380386,24896818,26150678,25112584,26702846,29092627,29374616,26660436,27663572,28059433,29432808,29119706,31124873,32129103,26450143,32462777,25471070,27435972,28898536,25220391,27860208,28363231,28782266,30289777,30044486,30625013,26393826,25209526,25496063,26990171,25916220,26110375,33933466,28548207,20799006,26561554,18164818,28336575,24973366,21292168,28576452,34086265,29634552,26061717,24716835,23752879,27342744,23834367,15772912,29897589,29016552,27417446,25931815,30565581,21292169,39308446,21385112,18810678,23905405,19032132,23726675,30968858,30189347,32169839,20030568,29419653,29016868,29266973,28810695,18957874,26839023,28371937,37881915,25479959,18708300,30597600,18828197,26586937,26229442,25247899,32788278,24238792,27231750,26439728,25265132,18762438,11755892,31145214,23216186,25643224,28946783,27137715,29207909,20801917,26161491,23265145,36548911,18425947,32210534,15882122,34120247,23269562,31267482,27582887,17296458,38305669,31058652,19662924,32552565,24452879,31201151,28768637,25473191,28919541,32376758,21382586,26328775,27046523,26573866,28504549,29870734,24020972,26126675,26016701,27476539,9163262,26845012,33331483,28944983,19713070,24249829,8800821,23766091,34284647,30652502,30036489,23534906,28423917,28445097,29979903,32488259,22950533,17900855,30284134,28176913,22224497,30853551,11779668,26535790,19137119,26248047,25802051,18924451,36475875,12656645,27137716,36440903,37969030,29405492,10601678,28127938,23836088,28337726,35135657,30288274,25539282,32733114,21663526,30358300,34795117,28035588,26109876,31721398,26582720,28850449,28849329,17243938,36504229,15221581,38502432,34367804,36517204,19052708,32005157,25278772,38320814,26449843,37822210,36102822,21269005,23439964,30215327,30793348,28339544,35544279,27938897,26567239,35255683,32779081,35484871,32569031,32839869,32310620,26344578,29210822,32086791,23900996,14505158,33707299,26535126,33872062,39069664,28769555,26312011,31682706,24866021,26990277,28466424,28483009,17588352,31346779,29098567,39110083,32450563,34334493,16225360,27299937,25729555,29621475,39367106,31291659,17940638,33635493,29420795,31361019,27003554,31853656,36984494,37081703,23788866,18473712,25183577,36490241,11755894,31849029,33132315,26678015,30778756,33206011,31061310,27807793,35441979,35509419,34631030,32622946,28830131,37225537,33142288,15004747,16706562,34633753,30863534,16207320,21604961,18598388,28515426,29884613,34348942,25964648,22876047,30613161,26977281,30890414,23052993,21672306,30951602,33965574,29664446,25164154,26757467,14622694,11837561,27486521,18680443,36971576,33063777,24428006,32523244,35739116,38166671,19345246,34281471,30340754,30125008,31857840,35481823,22493554,28143720,31054770,20694079,33135514,11328255,36791455,18721170,20100280,21063859,35993999,24904217,29888241,28499731,34617483,34423734,34833451,29700963,33388041,28554659,9924600,38314885,29730600,31029588,35790500,35544278,31321524,25414049,33849704,34387619,31416107,31517334,37505425,21769655,28034973,28547246,37533563,25847850,24883055,15153835,38576366,29391826,18828971,18686757,12183097,26371734,37664485,18443635,29980606,12882260,25539892,23788978,35255685,35785010,21677823,25207609,28990740,29618109,31126838,27803072,31211704,38178284,26115741,32158255,15153834,31091505,30613162,33747318,28510525,18454610,28529168,32022722,28428507,30788113,27022625,30932719,33556492,39063241,28935293,37790027,27490069,26317320,32863362,32280263,22653368,17315419,35267436,38792289,32723840,24332445,23953125,37195398,22300860,37534090,31774002,17984733,37546147,25290533,37744709,31292404,11309211,31308989,31587551,27546374,37347929,29273520,35172956,28850462,33608331,29139482,24833931,32188606,25356996,28105279,18777602,32547183,35781505,17163288,30858742,31738920,26557892,25985810,17983254,30010441,35356796,28410751,29322659,6130292,35051979,37983778,33063786,31720791,21494914,32209607,34830889,27764863,32978749,24829664,17532693,32699073,29906316,24829698,28325992,25208775,1354445,36503391,25962543,29528698,31643924,23861421,23973680,32833797,23397116,37834791,24840367,27367047,22997447,1678844,38393953,1675336,23243637,29362710,27509350,32743114,29545066,38435086,33185695,23159573,25888109,19698111,31877639,28576450,29317352,30310721,31567191,25207610,25419252,35097149,25194019,18628158,25349684,35719767,1517653,30557415,25516691,29668655,28965302,6115873,36011039,31724977,26699998,25765428,27456252,32843280,23971260,31643332,29950887,36713715,25520584,27857691,31474541,31587209,29210823,31643694,38587166,30581385,28289349,34387729,34028696,16021719,30104843,32309483,25207606,30820123,21602986,36777957,39301671,31124874,23667766[uid]

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Novel Oral Therapies for Opioid-induced Bowel Dysfunction in Patients with Chronic Noncancer Pain.

Holder RM, Rhee D. Holder RM, et al. Pharmacotherapy. 2016 Mar;36(3):287-99. doi: 10.1002/phar.1711. Epub 2016 Mar 6. Pharmacotherapy. 2016. PMID: 26945548 Review.

Cardiovascular Safety of the Selective μ-Opioid Receptor Antagonist Naloxegol: A Novel Therapy for Opioid-Induced Constipation.

White WB, Kowey P, Diva U, Sostek M, Tummala R. White WB, et al. J Cardiovasc Pharmacol Ther. 2018 Jul;23(4):309-317. doi: 10.1177/1074248418760239. Epub 2018 Mar 4. J Cardiovasc Pharmacol Ther. 2018. PMID: 29504415

Naloxegol: a review of its use in patients with opioid-induced constipation.

Garnock-Jones KP. Garnock-Jones KP. Drugs. 2015 Mar;75(4):419-25. doi: 10.1007/s40265-015-0357-2. Drugs. 2015. PMID: 25666542 Review.

Naloxegol for managing opioid-induced constipation.

Shelton KN, Clements JN. Shelton KN, et al. JAAPA. 2017 Sep;30(9):51-53. doi: 10.1097/01.JAA.0000522146.29435.c7. JAAPA. 2017. PMID: 28858018

Naloxegol: the first orally administered, peripherally acting, mu opioid receptor antagonist, approved for the treatment of opioid-induced constipation.

Corsetti M, Tack J. Corsetti M, et al. Drugs Today (Barc). 2015 Aug;51(8):479-89. doi: 10.1358/dot.2015.51.8.2364896. Drugs Today (Barc). 2015. PMID: 26380386 Review.

Naloxegol for opioid-induced constipation in patients with noncancer pain.

Chey WD, Webster L, Sostek M, Lappalainen J, Barker PN, Tack J. Chey WD, et al. N Engl J Med. 2014 Jun 19;370(25):2387-96. doi: 10.1056/NEJMoa1310246. Epub 2014 Jun 4. N Engl J Med. 2014. PMID: 24896818 Free article. Clinical Trial.

Naloxegol: A Novel Therapy in the Management of Opioid-Induced Constipation.

Jones R, Prommer E, Backstedt D. Jones R, et al. Am J Hosp Palliat Care. 2016 Nov;33(9):875-880. doi: 10.1177/1049909115593937. Epub 2015 Jul 6. Am J Hosp Palliat Care. 2016. PMID: 26150678 Review.

Randomised clinical trial: the long-term safety and tolerability of naloxegol in patients with pain and opioid-induced constipation.

Webster L, Chey WD, Tack J, Lappalainen J, Diva U, Sostek M. Webster L, et al. Aliment Pharmacol Ther. 2014 Oct;40(7):771-9. doi: 10.1111/apt.12899. Epub 2014 Aug 12. Aliment Pharmacol Ther. 2014. PMID: 25112584 Free article. Clinical Trial.

Opioid-induced constipation in chronic noncancer pain.

Weber HC. Weber HC. Curr Opin Endocrinol Diabetes Obes. 2016 Feb;23(1):11-7. doi: 10.1097/MED.0000000000000220. Curr Opin Endocrinol Diabetes Obes. 2016. PMID: 26702846 Review.

Evidence Based Review of Pharmacotherapy for Opioid-Induced Constipation in Noncancer Pain.

Murphy JA, Sheridan EA. Murphy JA, et al. Ann Pharmacother. 2018 Apr;52(4):370-379. doi: 10.1177/1060028017739637. Epub 2017 Nov 2. Ann Pharmacother. 2018. PMID: 29092627 Review.

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