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Year Number of Results
2000 2
2001 1
2002 1
2005 2
2007 2
2008 1
2009 1
2010 5
2011 4
2012 5
2013 8
2014 11
2015 12
2016 11
2017 5
2018 3
2019 5
2020 3
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Similar Articles for PMID: 28166210

74 results
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A water-mediated allosteric network governs activation of Aurora kinase A.
Cyphers S, Ruff EF, Behr JM, Chodera JD, Levinson NM. Cyphers S, et al. Nat Chem Biol. 2017 Apr;13(4):402-408. doi: 10.1038/nchembio.2296. Epub 2017 Feb 6. Nat Chem Biol. 2017. PMID: 28166210 Free PMC article.
A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation.
Ruff EF, Muretta JM, Thompson AR, Lake EW, Cyphers S, Albanese SK, Hanson SM, Behr JM, Thomas DD, Chodera JD, Levinson NM. Ruff EF, et al. Elife. 2018 Feb 21;7:e32766. doi: 10.7554/eLife.32766. Elife. 2018. PMID: 29465396 Free PMC article.
Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states.
Lake EW, Muretta JM, Thompson AR, Rasmussen DM, Majumdar A, Faber EB, Ruff EF, Thomas DD, Levinson NM. Lake EW, et al. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E11894-E11903. doi: 10.1073/pnas.1811158115. Epub 2018 Dec 5. Proc Natl Acad Sci U S A. 2018. PMID: 30518564 Free PMC article.
Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2.
Zorba A, Buosi V, Kutter S, Kern N, Pontiggia F, Cho YJ, Kern D. Zorba A, et al. Elife. 2014 May 27;3:e02667. doi: 10.7554/eLife.02667. Elife. 2014. PMID: 24867643 Free PMC article.
Structure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.
James KA, Verkhivker GM. James KA, et al. PLoS One. 2014 Nov 26;9(11):e113488. doi: 10.1371/journal.pone.0113488. eCollection 2014. PLoS One. 2014. PMID: 25427151 Free PMC article.
The multifaceted allosteric regulation of Aurora kinase A.
Levinson NM. Levinson NM. Biochem J. 2018 Jun 26;475(12):2025-2042. doi: 10.1042/BCJ20170771. Biochem J. 2018. PMID: 29946042 Free PMC article. Review.
Allosteric Targeting of Aurora A Kinase Using Small Molecules: A Step Forward Towards Next Generation Medicines?
Panicker RC, Coyne AG, Srinivasan R. Panicker RC, et al. Curr Med Chem. 2019;26(13):2234-2242. doi: 10.2174/0929867324666170727120315. Curr Med Chem. 2019. PMID: 28748768 Review.
A TPX2 Proteomimetic Has Enhanced Affinity for Aurora-A Due to Hydrocarbon Stapling of a Helix.
Rennie YK, McIntyre PJ, Akindele T, Bayliss R, Jamieson AG. Rennie YK, et al. ACS Chem Biol. 2016 Dec 16;11(12):3383-3390. doi: 10.1021/acschembio.6b00727. Epub 2016 Nov 1. ACS Chem Biol. 2016. PMID: 27775325 Free article.
Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single-Molecule Spectroscopy.
Gilburt JAH, Sarkar H, Sheldrake P, Blagg J, Ying L, Dodson CA. Gilburt JAH, et al. Angew Chem Int Ed Engl. 2017 Sep 11;56(38):11409-11414. doi: 10.1002/anie.201704654. Epub 2017 Aug 7. Angew Chem Int Ed Engl. 2017. PMID: 28700101 Free PMC article.
Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain.
Burgess SG, Oleksy A, Cavazza T, Richards MW, Vernos I, Matthews D, Bayliss R. Burgess SG, et al. Open Biol. 2016 Jul;6(7):160089. doi: 10.1098/rsob.160089. Open Biol. 2016. PMID: 27411893 Free PMC article.
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