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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 1
1978 1
1987 1
1995 1
2000 1
2004 1
2007 3
2009 1
2010 2
2011 7
2012 7
2013 9
2014 9
2015 20
2016 21
2017 9
2018 13
2019 7
2020 2
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Similar Articles for PMID: 28263965

104 results
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L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH.
Intlekofer AM, Wang B, Liu H, Shah H, Carmona-Fontaine C, Rustenburg AS, Salah S, Gunner MR, Chodera JD, Cross JR, Thompson CB. Intlekofer AM, et al. Nat Chem Biol. 2017 May;13(5):494-500. doi: 10.1038/nchembio.2307. Epub 2017 Mar 6. Nat Chem Biol. 2017. PMID: 28263965 Free PMC article.
Hypoxia Induces Production of L-2-Hydroxyglutarate.
Intlekofer AM, Dematteo RG, Venneti S, Finley LW, Lu C, Judkins AR, Rustenburg AS, Grinaway PB, Chodera JD, Cross JR, Thompson CB. Intlekofer AM, et al. Cell Metab. 2015 Aug 4;22(2):304-11. doi: 10.1016/j.cmet.2015.06.023. Epub 2015 Jul 23. Cell Metab. 2015. PMID: 26212717 Free PMC article.
Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling.
Nadtochiy SM, Schafer X, Fu D, Nehrke K, Munger J, Brookes PS. Nadtochiy SM, et al. J Biol Chem. 2016 Sep 16;291(38):20188-97. doi: 10.1074/jbc.M116.738799. Epub 2016 Aug 10. J Biol Chem. 2016. PMID: 27510037 Free PMC article.
Oncometabolites d- and l-2-Hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions.
Chen F, Bian K, Tang Q, Fedeles BI, Singh V, Humulock ZT, Essigmann JM, Li D. Chen F, et al. Chem Res Toxicol. 2017 Apr 17;30(4):1102-1110. doi: 10.1021/acs.chemrestox.7b00009. Epub 2017 Mar 24. Chem Res Toxicol. 2017. PMID: 28269980 Free PMC article.
Mutant IDH1 enhances the production of 2-hydroxyglutarate due to its kinetic mechanism.
Rendina AR, Pietrak B, Smallwood A, Zhao H, Qi H, Quinn C, Adams ND, Concha N, Duraiswami C, Thrall SH, Sweitzer S, Schwartz B. Rendina AR, et al. Biochemistry. 2013 Jul 2;52(26):4563-77. doi: 10.1021/bi400514k. Epub 2013 Jun 21. Biochemistry. 2013. PMID: 23731180
Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis.
Teng X, Emmett MJ, Lazar MA, Goldberg E, Rabinowitz JD. Teng X, et al. ACS Chem Biol. 2016 Sep 16;11(9):2420-7. doi: 10.1021/acschembio.6b00290. Epub 2016 Jul 7. ACS Chem Biol. 2016. PMID: 27333189 Free PMC article.
L-2-hydroxyglutaric aciduria, a defect of metabolite repair.
Rzem R, Vincent MF, Van Schaftingen E, Veiga-da-Cunha M. Rzem R, et al. J Inherit Metab Dis. 2007 Oct;30(5):681-9. doi: 10.1007/s10545-007-0487-0. Epub 2007 Jun 21. J Inherit Metab Dis. 2007. PMID: 17603759
Mitochondrial 2-hydroxyglutarate metabolism.
Engqvist MK, E├čer C, Maier A, Lercher MJ, Maurino VG. Engqvist MK, et al. Mitochondrion. 2014 Nov;19 Pt B:275-81. doi: 10.1016/j.mito.2014.02.009. Epub 2014 Feb 21. Mitochondrion. 2014. PMID: 24561575 Review.
Drosophila larvae synthesize the putative oncometabolite L-2-hydroxyglutarate during normal developmental growth.
Li H, Chawla G, Hurlburt AJ, Sterrett MC, Zaslaver O, Cox J, Karty JA, Rosebrock AP, Caudy AA, Tennessen JM. Li H, et al. Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1353-1358. doi: 10.1073/pnas.1614102114. Epub 2017 Jan 23. Proc Natl Acad Sci U S A. 2017. PMID: 28115720 Free PMC article.
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, Rabinowitz JD, Cantley LC, Thompson CB, Vander Heiden MG, Su SM. Dang L, et al. Nature. 2009 Dec 10;462(7274):739-44. doi: 10.1038/nature08617. Nature. 2009. PMID: 19935646 Free PMC article.
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