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29554195,29554174,33945639,23633340,15846751,20464739,20393943,19370682,19821344,16235409,16235410,18485271,17166990,26594816,20110019,35230437,19588447,18485272,21975759,17605896,19160317,29400090,17054161,31883519,18484216,20440920,24138688,20528600,33387985,24369798,34009257,15003036,16235393,20153029,15674901,23235678,29741837,28427362,22928176,19370661,24459050,29207999,20824877,20581409,25773561,23450613,31194879,19768640,29545018,15265853,24321802,34536699,20528601,23744625,18500509,24919052,17291852,15606218,26061910,25226477,19633090,31584145,27070946,16316864,19651467,26614594,11843317,20110003,19026757,18803555,31668101,19769705,25226849,26897389,16754916,26850307,20935397,29949492,22926172,35443946,12517241,16357579,22035511,33270095,32339657,24153452,21718577,34666208,22281166,34913809,21749735,33979557,30261998,32911138,36702246,30358366,29863899,21390219,18788245,28974349,24797158,27351988,25213056,14693296,22233316,19557208,17111718,19648384,32692744,30359144,19144173,34470194,32492747,29083972,20446755,14720010,22081088,25038591,35364341,33093120,31862434,32658381,30638161,30311821,36036456,35914659,34400314,32302768,34806537,15683612,28425216,35131990,30472355,29378305,21162597,11486981,23534447,11224725,30575845,20164771,28881155,28284731,10597760,15481283,30265259,31422716,17714061,33940213,17092772,23818758,12699217,35396495,18695847,24801458,29869050,18043277,31724457,31601714,28941668,30640210,15794718,15591891,21292760,37054412,19678711,33474708,20714372,9112058,30839181,15658883,23904098,27172856,23888347,16448962,18518783,15219172,31206220,25114786,15301799,15167017,35099342,32430423,12877241,18360644,19544175,32044930,30367400,31144543,33026595,36313228,29273557,32712029,22536582,20425515,35023469,15336474,20210730,23885171,35181174,29102337,33247470,24621682,31375615,15715182,33706416,34149408,15591892,30550809,32244024,32197337,31900271,23061609,21463536,17439402,34718214,33115481,36170130,18536625,33829387,34128852,29906501,30836232,32006721,30714822,28847655,25183364,22259262,8685084,33053199,31468340,9474367,33713011,11958761,19093316,31208499,32943399,10917332,30772478,32885783,22056555,30298471,18390944,17067521,12603186,30014094,11469360,31048346,15283640,31923550,32906192,21337060,35050462,28864055,14679669,34024646,16512694,21437145,11517021,16409012,22754711,32603565,35921883,12870839,14769264,32665193,34265629,35218965,36974609,19055201,31264485,29885281,33363311,35080294,18422381,36329425,31972134,17376363,19953030,22559870,12739327,10749462,22218743,21858482,31961091,34704824,20019345,32738113,18046857,35272859,35143150,9615840,10682167,7592242,34753370,20462794,11785372,8676612,28295526,34699298,28332884,29662064,33479111,31906744,8620952,23370915,35959199,32550224,35463694,35786288,18292850,31971234,34842585,31804501,36894283,35748071,8962585,30453869,9609608,30395748,36371063,14579990,10427580,19904206,33125311,30513226,15292843,29245242,34774528,30846467,11011752,29393535,19221157,31742937,18846978,33630543,36331361,26734457,33461348,34627538,21045699,12476077,29972079,19212285,25275432,32983452,34743311,12428542,31320857,32801203,19727354,35379389,32747344,30741637,28446776,32303671,29667525,18282372,34469362,34862766,31508254,28689842,30014093,33393641,11883740,35787225,16129327,35663,21437038,31501737,22891187,33741383,19693460,10682166,34795026,27826962,32068437,32192946,36528520,21437051,11288220,30302951,36323417,31178722,29256220,25441637,28958739,36008492,19663668,19171611,12877239,34044743,28081237,11737390,27386055,21769507,21394429,36600236,34568369,35025962,31187518,17713993,14506533,24936302,11153581,31729320,34061344,35118373,11188507,22386508,18327346,34954637,30127653,32297708,32130345,34262968,35377402,34353777,1347676,16292185,35377410,34143685,33682397,24259987,29768146,19129942,19734352,36127355,35669010,21666762,35330503,29641271,32732018,34141051,34557301,32905889,35000364,26632421,23943778,20674820,33528938,33496162,36670594,36039465,35662393,32210541,32997402,1684702,21796419,35923054,29261858,34366865,35722499,32802826,24418963,20945162,17530142,28616286,36565166,34163182,27335952,36192103,30285350,32861927,35430944,30365368,30765484,31290808,15756900,36582191,14685501,26957062,14676853,27826957,29913490,34872572,30988264,23283014,35705210,32105431,36642111,21701574,34598055,32108606,21509289,35023932,32002694,23118631,27293845,21966601,35350280,36461938,19246716,22646862,21139715,32256100,35412724,23819646,34893481,36968614,34975055,36072402,7489814,31350049,34785910,32021311,18713658,30452560,24581430,36575356,35268392,31896681,16021707,34787792,31177857,33765485,32354861,25228994,19424682,15252915,32232892,36087942,35052792,22977410,22348203,19229229,36286780,18728834,31339331,31729319,31339340,33292326,34861014,26445555,30408269,23282981,27546969,31700392,31416811,24734097,11985440,32363204,25606126,34167232,26175562,22375279,34239392,33030964,31813588,36036237,30600970,31552712,33566114,35035553,18748091,35927839,35848659,11936990,36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Association of Inhaled Corticosteroids and Long-Acting β-Agonists as Controller and Quick Relief Therapy With Exacerbations and Symptom Control in Persistent Asthma: A Systematic Review and Meta-analysis.

Sobieraj DM, Weeda ER, Nguyen E, Coleman CI, White CM, Lazarus SC, Blake KV, Lang JE, Baker WL. Sobieraj DM, et al. JAMA. 2018 Apr 10;319(14):1485-1496. doi: 10.1001/jama.2018.2769. JAMA. 2018. PMID: 29554195 Free PMC article. Review.

Association of Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists With Asthma Control in Patients With Uncontrolled, Persistent Asthma: A Systematic Review and Meta-analysis.

Sobieraj DM, Baker WL, Nguyen E, Weeda ER, Coleman CI, White CM, Lazarus SC, Blake KV, Lang JE. Sobieraj DM, et al. JAMA. 2018 Apr 10;319(14):1473-1484. doi: 10.1001/jama.2018.2757. JAMA. 2018. PMID: 29554174 Free PMC article. Review.

Combination fixed-dose beta agonist and steroid inhaler as required for adults or children with mild asthma.

Crossingham I, Turner S, Ramakrishnan S, Fries A, Gowell M, Yasmin F, Richardson R, Webb P, O'Boyle E, Hinks TS. Crossingham I, et al. Cochrane Database Syst Rev. 2021 May 4;5(5):CD013518. doi: 10.1002/14651858.CD013518.pub2. Cochrane Database Syst Rev. 2021. PMID: 33945639 Free PMC article.

Combination formoterol and budesonide as maintenance and reliever therapy versus current best practice (including inhaled steroid maintenance), for chronic asthma in adults and children.

Cates CJ, Karner C. Cates CJ, et al. Cochrane Database Syst Rev. 2013 Apr 30;2013(4):CD007313. doi: 10.1002/14651858.CD007313.pub3. Cochrane Database Syst Rev. 2013. PMID: 23633340 Free PMC article. Review.

Addition of inhaled long-acting beta2-agonists to inhaled steroids as first line therapy for persistent asthma in steroid-naive adults.

Ni CM, Greenstone IR, Ducharme FM. Ni CM, et al. Cochrane Database Syst Rev. 2005 Apr 18;(2):CD005307. doi: 10.1002/14651858.CD005307. Cochrane Database Syst Rev. 2005. Update in: Cochrane Database Syst Rev. 2009 Oct 07;(4):CD005307. doi: 10.1002/14651858.CD005307.pub2. PMID: 15846751 Updated. Review.

Addition of long-acting beta2-agonists to inhaled corticosteroids versus same dose inhaled corticosteroids for chronic asthma in adults and children.

Ducharme FM, Ni Chroinin M, Greenstone I, Lasserson TJ. Ducharme FM, et al. Cochrane Database Syst Rev. 2010 May 12;(5):CD005535. doi: 10.1002/14651858.CD005535.pub2. Cochrane Database Syst Rev. 2010. PMID: 20464739 Free PMC article. Review.

Addition of long-acting beta2-agonists to inhaled steroids versus higher dose inhaled steroids in adults and children with persistent asthma.

Ducharme FM, Ni Chroinin M, Greenstone I, Lasserson TJ. Ducharme FM, et al. Cochrane Database Syst Rev. 2010 Apr 14;(4):CD005533. doi: 10.1002/14651858.CD005533.pub2. Cochrane Database Syst Rev. 2010. PMID: 20393943 Free PMC article. Review.

Combination formoterol and budesonide as maintenance and reliever therapy versus inhaled steroid maintenance for chronic asthma in adults and children.

Cates CJ, Lasserson TJ. Cates CJ, et al. Cochrane Database Syst Rev. 2009 Apr 15;(2):CD007313. doi: 10.1002/14651858.CD007313.pub2. Cochrane Database Syst Rev. 2009. Update in: Cochrane Database Syst Rev. 2013 Apr 30;(4):CD007313. doi: 10.1002/14651858.CD007313.pub3. PMID: 19370682 Free PMC article. Updated. Review.

Addition of inhaled long-acting beta2-agonists to inhaled steroids as first line therapy for persistent asthma in steroid-naive adults and children.

Ni Chroinin M, Greenstone I, Lasserson TJ, Ducharme FM. Ni Chroinin M, et al. Cochrane Database Syst Rev. 2009 Oct 7;2009(4):CD005307. doi: 10.1002/14651858.CD005307.pub2. Cochrane Database Syst Rev. 2009. PMID: 19821344 Free PMC article. Review.

Combination of inhaled long-acting beta2-agonists and inhaled steroids versus higher dose of inhaled steroids in children and adults with persistent asthma.

Greenstone IR, Ni Chroinin MN, Masse V, Danish A, Magdalinos H, Zhang X, Ducharme FM. Greenstone IR, et al. Cochrane Database Syst Rev. 2005 Oct 19;(4):CD005533. doi: 10.1002/14651858.CD005533. Cochrane Database Syst Rev. 2005. Update in: Cochrane Database Syst Rev. 2010 Apr 14;(4):CD005533. doi: 10.1002/14651858.CD005533.pub2. PMID: 16235409 Updated. Review.

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