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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1986 1
1993 1
1994 1
1995 2
1996 3
1997 4
1998 2
1999 5
2000 2
2001 3
2002 6
2003 5
2004 6
2005 3
2006 1
2007 9
2008 9
2009 5
2010 8
2011 6
2012 4
2013 5
2014 6
2015 8
2016 9
2017 2
2018 4
2019 4
2020 8
2021 3
2022 3
2023 3

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130 results

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Page 1
Cardiac Sarcomere Signaling in Health and Disease.
Martin AA, Thompson BR, Hahn D, Angulski ABB, Hosny N, Cohen H, Metzger JM. Martin AA, et al. Among authors: metzger jm. Int J Mol Sci. 2022 Dec 19;23(24):16223. doi: 10.3390/ijms232416223. Int J Mol Sci. 2022. PMID: 36555864 Free PMC article. Review.
Cardiac myocyte intrinsic contractility and calcium handling deficits underlie heart organ dysfunction in murine cancer cachexia.
Law ML, Metzger JM. Law ML, et al. Among authors: metzger jm. Sci Rep. 2021 Dec 8;11(1):23627. doi: 10.1038/s41598-021-02688-z. Sci Rep. 2021. PMID: 34880268 Free PMC article.
We hypothesized that isolated heart and cardiac myocyte functional deficits underlie in vivo contractile dysfunction. ...Ex vivo perfused hearts from cachectic animals exhibited marked contraction and relaxation deficits during basal and pacing conditions. ...
We hypothesized that isolated heart and cardiac myocyte functional deficits underlie in vivo contractile dysfunction. ...Ex vivo perf …
Molecular cardiology in translation: gene, cell and chemical-based experimental therapeutics for the failing heart.
Turner I, Belema-Bedada F, Martindale J, Townsend D, Wang W, Palpant N, Yasuda SC, Barnabei M, Fomicheva E, Metzger JM. Turner I, et al. Among authors: metzger jm. J Cardiovasc Transl Res. 2008 Dec;1(4):317-27. doi: 10.1007/s12265-008-9065-6. J Cardiovasc Transl Res. 2008. PMID: 19956787 Free PMC article. Review.
Acquired and inherited diseases of the heart represent a major health care issue in this country and throughout the World. ...Nevertheless, it is apparent that even with the best care, current treatment strategies and therapeutics are inadequate for treating heart d …
Acquired and inherited diseases of the heart represent a major health care issue in this country and throughout the World. ...Neverth …
Cardiac Muscle Membrane Stabilization in Myocardial Reperfusion Injury.
Houang EM, Bartos J, Hackel BJ, Lodge TP, Yannopoulos D, Bates FS, Metzger JM. Houang EM, et al. Among authors: metzger jm. JACC Basic Transl Sci. 2019 Apr 29;4(2):275-287. doi: 10.1016/j.jacbts.2019.01.009. eCollection 2019 Apr. JACC Basic Transl Sci. 2019. PMID: 31061929 Free PMC article. Review.
In Duchenne muscular dystrophy, an inherited and uniformly fatal disease of progressive muscle deterioration, muscle membrane instability is the primary cause of disease, including significant heart disease, for which there is no cure or highly effective treatment. ...Coll …
In Duchenne muscular dystrophy, an inherited and uniformly fatal disease of progressive muscle deterioration, muscle membrane instability is …
Tuning cardiac performance in ischemic heart disease and failure by modulating myofilament function.
Day SM, Westfall MV, Metzger JM. Day SM, et al. Among authors: metzger jm. J Mol Med (Berl). 2007 Sep;85(9):911-21. doi: 10.1007/s00109-007-0181-6. Epub 2007 Mar 30. J Mol Med (Berl). 2007. PMID: 17396243 Review.
In contrast, myofilament Ca(2+) sensitivity can be increased in chronic heart failure, owing in part to decreased phosphorylation of troponin I, the inhibitory subunit of the troponin regulatory complex. ...We also discuss the beneficial effects of a genetically engineered …
In contrast, myofilament Ca(2+) sensitivity can be increased in chronic heart failure, owing in part to decreased phosphorylation of …
Calcium mishandling in diastolic dysfunction: mechanisms and potential therapies.
Asp ML, Martindale JJ, Heinis FI, Wang W, Metzger JM. Asp ML, et al. Among authors: metzger jm. Biochim Biophys Acta. 2013 Apr;1833(4):895-900. doi: 10.1016/j.bbamcr.2012.09.007. Epub 2012 Sep 27. Biochim Biophys Acta. 2013. PMID: 23022395 Free PMC article. Review.
There are currently no therapies available that directly target the heart pump defects in diastolic function. Calcium mishandling is a hallmark of heart disease and has been the subject of a large body of research. ...An alternative approach to address calcium misha …
There are currently no therapies available that directly target the heart pump defects in diastolic function. Calcium mishandling is …
Duchenne muscular dystrophy: disease mechanism and therapeutic strategies.
Bez Batti Angulski A, Hosny N, Cohen H, Martin AA, Hahn D, Bauer J, Metzger JM. Bez Batti Angulski A, et al. Among authors: metzger jm. Front Physiol. 2023 Jun 26;14:1183101. doi: 10.3389/fphys.2023.1183101. eCollection 2023. Front Physiol. 2023. PMID: 37435300 Free PMC article. Review.
Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes.
Bedada FB, Wheelwright M, Metzger JM. Bedada FB, et al. Among authors: metzger jm. Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1829-38. doi: 10.1016/j.bbamcr.2015.11.005. Epub 2015 Nov 11. Biochim Biophys Acta. 2016. PMID: 26578113 Free PMC article. Review.
Human heart failure due to myocardial infarction is a major health concern. ...This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel....
Human heart failure due to myocardial infarction is a major health concern. ...This article is part of a Special Issue entitled: Card …
Cell biology of sarcomeric protein engineering: disease modeling and therapeutic potential.
Thompson BR, Metzger JM. Thompson BR, et al. Among authors: metzger jm. Anat Rec (Hoboken). 2014 Sep;297(9):1663-9. doi: 10.1002/ar.22966. Anat Rec (Hoboken). 2014. PMID: 25125179 Free PMC article. Review.
Ordered arrays of sarcomeric proteins, held in stoichiometric balance with each other, respond to calcium to coordinate contraction and relaxation of the heart. Altered sarcomeric structure-function underlies the primary basis of disease in multiple acquired and inherited …
Ordered arrays of sarcomeric proteins, held in stoichiometric balance with each other, respond to calcium to coordinate contraction and rela …
Designing heart performance by gene transfer.
Davis J, Westfall MV, Townsend D, Blankinship M, Herron TJ, Guerrero-Serna G, Wang W, Devaney E, Metzger JM. Davis J, et al. Among authors: metzger jm. Physiol Rev. 2008 Oct;88(4):1567-651. doi: 10.1152/physrev.00039.2007. Physiol Rev. 2008. PMID: 18923190 Free article. Review.
The birth of molecular cardiology can be traced to the development and implementation of high-fidelity genetic approaches for manipulating the heart. Recombinant viral vector-based technology offers a highly effective approach to genetically engineer cardiac muscle in vitr …
The birth of molecular cardiology can be traced to the development and implementation of high-fidelity genetic approaches for manipulating t …
130 results