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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1986 1
1993 1
1994 1
1995 2
1996 3
1997 4
1998 2
1999 5
2000 2
2001 3
2002 6
2003 5
2004 6
2005 3
2006 1
2007 9
2008 9
2009 5
2010 8
2011 6
2012 4
2013 5
2014 6
2015 8
2016 9
2017 2
2018 4
2019 4
2020 8
2021 3
2022 3
2023 3
2024 3
2025 2
2026 1

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136 results

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Page 1
Duchenne muscular dystrophy: disease mechanism and therapeutic strategies.
Bez Batti Angulski A, Hosny N, Cohen H, Martin AA, Hahn D, Bauer J, Metzger JM. Bez Batti Angulski A, et al. Among authors: metzger jm. Front Physiol. 2023 Jun 26;14:1183101. doi: 10.3389/fphys.2023.1183101. eCollection 2023. Front Physiol. 2023. PMID: 37435300 Free PMC article. Review.
Synthetic bottlebrush block copolymer prevents disease onset in Duchenne muscular dystrophy.
Cohen H, Angulski ABB, Quick JD, Kuebler TS, Thompson BR, Bauer J, Hahn D, Townsend D, Hassler JF, Hackel BJ, Lodge TP, Sham YY, Bates FS, Metzger JM. Cohen H, et al. Among authors: metzger jm. Proc Natl Acad Sci U S A. 2025 Oct 21;122(42):e2513599122. doi: 10.1073/pnas.2513599122. Epub 2025 Oct 13. Proc Natl Acad Sci U S A. 2025. PMID: 41082666 Free PMC article.
DMD treatment requires a body-wide approach to target all diseased striated muscles: limb, respiratory, and heart. To address this, we focus studies on blocking the onset of muscle membrane instability, the primary defect in DMD, as a promising yet unmet druggable target. …
DMD treatment requires a body-wide approach to target all diseased striated muscles: limb, respiratory, and heart. To address this, w …
Cardiac Sarcomere Signaling in Health and Disease.
Martin AA, Thompson BR, Hahn D, Angulski ABB, Hosny N, Cohen H, Metzger JM. Martin AA, et al. Among authors: metzger jm. Int J Mol Sci. 2022 Dec 19;23(24):16223. doi: 10.3390/ijms232416223. Int J Mol Sci. 2022. PMID: 36555864 Free PMC article. Review.
Cardiac Muscle Membrane Stabilization in Myocardial Reperfusion Injury.
Houang EM, Bartos J, Hackel BJ, Lodge TP, Yannopoulos D, Bates FS, Metzger JM. Houang EM, et al. Among authors: metzger jm. JACC Basic Transl Sci. 2019 Apr 29;4(2):275-287. doi: 10.1016/j.jacbts.2019.01.009. eCollection 2019 Apr. JACC Basic Transl Sci. 2019. PMID: 31061929 Free PMC article. Review.
Recent advances using clinically relevant small and large animal models of heart disease are discussed. In addition, mechanistic insights into the copolymer-muscle membrane interface, featuring atomistic, molecular, and physiological structure-function approaches are highl …
Recent advances using clinically relevant small and large animal models of heart disease are discussed. In addition, mechanistic insi …
Cardiac myocyte intrinsic contractility and calcium handling deficits underlie heart organ dysfunction in murine cancer cachexia.
Law ML, Metzger JM. Law ML, et al. Among authors: metzger jm. Sci Rep. 2021 Dec 8;11(1):23627. doi: 10.1038/s41598-021-02688-z. Sci Rep. 2021. PMID: 34880268 Free PMC article.
We hypothesized that isolated heart and cardiac myocyte functional deficits underlie in vivo contractile dysfunction. ...Ex vivo perfused hearts from cachectic animals exhibited marked contraction and relaxation deficits during basal and pacing conditions. ...
We hypothesized that isolated heart and cardiac myocyte functional deficits underlie in vivo contractile dysfunction. ...Ex vivo perf …
Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes.
Bedada FB, Wheelwright M, Metzger JM. Bedada FB, et al. Among authors: metzger jm. Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1829-38. doi: 10.1016/j.bbamcr.2015.11.005. Epub 2015 Nov 11. Biochim Biophys Acta. 2016. PMID: 26578113 Free PMC article. Review.
Human heart failure due to myocardial infarction is a major health concern. The paucity of organs for transplantation limits curative approaches for the diseased and failing adult heart. ...This article is part of a Special Issue entitled: Cardiomyocyte Biology: Int …
Human heart failure due to myocardial infarction is a major health concern. The paucity of organs for transplantation limits curative …
Myofilament-based physiological regulatory compensation preserves diastolic function in failing hearts with severe Ca2+ handling deficits.
Heinis FI, Thompson BR, Gulati R, Wheelwright M, Metzger JM. Heinis FI, et al. Among authors: metzger jm. JCI Insight. 2024 Feb 8;9(6):e163334. doi: 10.1172/jci.insight.163334. JCI Insight. 2024. PMID: 38329806 Free PMC article.
The mechanism underlying the sustained in vivo heart performance in the weeks prior to complete heart pump failure and death is not clear and is important to understand. ...Interestingly, data show increased cardiac troponin I (cTnI) serine 23/24 phosphorylation con …
The mechanism underlying the sustained in vivo heart performance in the weeks prior to complete heart pump failure and death i …
Molecular cardiology in translation: gene, cell and chemical-based experimental therapeutics for the failing heart.
Turner I, Belema-Bedada F, Martindale J, Townsend D, Wang W, Palpant N, Yasuda SC, Barnabei M, Fomicheva E, Metzger JM. Turner I, et al. Among authors: metzger jm. J Cardiovasc Transl Res. 2008 Dec;1(4):317-27. doi: 10.1007/s12265-008-9065-6. J Cardiovasc Transl Res. 2008. PMID: 19956787 Free PMC article. Review.
Acquired and inherited diseases of the heart represent a major health care issue in this country and throughout the World. Clinical medicine has made important advancements in the past quarter century to enable several effective treatment regimes for cardiac patients. ...F …
Acquired and inherited diseases of the heart represent a major health care issue in this country and throughout the World. Clinical m …
Calcium mishandling in diastolic dysfunction: mechanisms and potential therapies.
Asp ML, Martindale JJ, Heinis FI, Wang W, Metzger JM. Asp ML, et al. Among authors: metzger jm. Biochim Biophys Acta. 2013 Apr;1833(4):895-900. doi: 10.1016/j.bbamcr.2012.09.007. Epub 2012 Sep 27. Biochim Biophys Acta. 2013. PMID: 23022395 Free PMC article. Review.
There are currently no therapies available that directly target the heart pump defects in diastolic function. Calcium mishandling is a hallmark of heart disease and has been the subject of a large body of research. ...An alternative approach to address calcium misha …
There are currently no therapies available that directly target the heart pump defects in diastolic function. Calcium mishandling is …
136 results