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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1986 1
1993 1
1994 1
1995 2
1996 3
1997 4
1998 2
1999 5
2000 2
2001 3
2002 6
2003 5
2004 6
2005 3
2006 1
2007 9
2008 9
2009 5
2010 8
2011 6
2012 4
2013 5
2014 6
2015 8
2016 9
2017 2
2018 4
2019 4
2020 8
2021 3
2022 0
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125 results
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Page 1
Cardiac myocyte intrinsic contractility and calcium handling deficits underlie heart organ dysfunction in murine cancer cachexia.
Law ML, Metzger JM. Law ML, et al. Among authors: metzger jm. Sci Rep. 2021 Dec 8;11(1):23627. doi: 10.1038/s41598-021-02688-z. Sci Rep. 2021. PMID: 34880268 Free PMC article.
We hypothesized that isolated heart and cardiac myocyte functional deficits underlie in vivo contractile dysfunction. ...Ex vivo perfused hearts from cachectic animals exhibited marked contraction and relaxation deficits during basal and pacing conditions. ...
We hypothesized that isolated heart and cardiac myocyte functional deficits underlie in vivo contractile dysfunction. ...Ex vivo perf …
Cardiac Muscle Membrane Stabilization in Myocardial Reperfusion Injury.
Houang EM, Bartos J, Hackel BJ, Lodge TP, Yannopoulos D, Bates FS, Metzger JM. Houang EM, et al. Among authors: metzger jm. JACC Basic Transl Sci. 2019 Apr 29;4(2):275-287. doi: 10.1016/j.jacbts.2019.01.009. eCollection 2019 Apr. JACC Basic Transl Sci. 2019. PMID: 31061929 Free PMC article. Review.
In Duchenne muscular dystrophy, an inherited and uniformly fatal disease of progressive muscle deterioration, muscle membrane instability is the primary cause of disease, including significant heart disease, for which there is no cure or highly effective treatment. ...Coll …
In Duchenne muscular dystrophy, an inherited and uniformly fatal disease of progressive muscle deterioration, muscle membrane instability is …
Molecular cardiology in translation: gene, cell and chemical-based experimental therapeutics for the failing heart.
Turner I, Belema-Bedada F, Martindale J, Townsend D, Wang W, Palpant N, Yasuda SC, Barnabei M, Fomicheva E, Metzger JM. Turner I, et al. Among authors: metzger jm. J Cardiovasc Transl Res. 2008 Dec;1(4):317-27. doi: 10.1007/s12265-008-9065-6. J Cardiovasc Transl Res. 2008. PMID: 19956787 Free PMC article. Review.
Acquired and inherited diseases of the heart represent a major health care issue in this country and throughout the World. ...Nevertheless, it is apparent that even with the best care, current treatment strategies and therapeutics are inadequate for treating heart d …
Acquired and inherited diseases of the heart represent a major health care issue in this country and throughout the World. ...Neverth …
Myelin Basic Protein and Cardiac Sympathetic Neurodegeneration in Nonhuman Primates.
Metzger JM, Matsoff HN, Vu D, Zinnen AD, Jones KM, Bondarenko V, Simmons HA, Moore CF, Emborg ME. Metzger JM, et al. Neurol Res Int. 2021 Oct 4;2021:4776610. doi: 10.1155/2021/4776610. eCollection 2021. Neurol Res Int. 2021. PMID: 34646580 Free PMC article.
Minimal myelination is proposed to be a contributing factor to the preferential nigral neuronal loss in Parkinson's disease (PD). Similar to nigral dopaminergic neurons, sympathetic neurons innervating the heart have long, thin axons which are unmyelinated or minima …
Minimal myelination is proposed to be a contributing factor to the preferential nigral neuronal loss in Parkinson's disease (PD). Sim …
Tuning cardiac performance in ischemic heart disease and failure by modulating myofilament function.
Day SM, Westfall MV, Metzger JM. Day SM, et al. Among authors: metzger jm. J Mol Med (Berl). 2007 Sep;85(9):911-21. doi: 10.1007/s00109-007-0181-6. Epub 2007 Mar 30. J Mol Med (Berl). 2007. PMID: 17396243 Review.
In contrast, myofilament Ca(2+) sensitivity can be increased in chronic heart failure, owing in part to decreased phosphorylation of troponin I, the inhibitory subunit of the troponin regulatory complex. ...We also discuss the beneficial effects of a genetically engineered …
In contrast, myofilament Ca(2+) sensitivity can be increased in chronic heart failure, owing in part to decreased phosphorylation of …
Designing heart performance by gene transfer.
Davis J, Westfall MV, Townsend D, Blankinship M, Herron TJ, Guerrero-Serna G, Wang W, Devaney E, Metzger JM. Davis J, et al. Among authors: metzger jm. Physiol Rev. 2008 Oct;88(4):1567-651. doi: 10.1152/physrev.00039.2007. Physiol Rev. 2008. PMID: 18923190 Free article. Review.
The birth of molecular cardiology can be traced to the development and implementation of high-fidelity genetic approaches for manipulating the heart. Recombinant viral vector-based technology offers a highly effective approach to genetically engineer cardiac muscle in vitr …
The birth of molecular cardiology can be traced to the development and implementation of high-fidelity genetic approaches for manipulating t …
Calcium mishandling in diastolic dysfunction: mechanisms and potential therapies.
Asp ML, Martindale JJ, Heinis FI, Wang W, Metzger JM. Asp ML, et al. Among authors: metzger jm. Biochim Biophys Acta. 2013 Apr;1833(4):895-900. doi: 10.1016/j.bbamcr.2012.09.007. Epub 2012 Sep 27. Biochim Biophys Acta. 2013. PMID: 23022395 Free PMC article. Review.
There are currently no therapies available that directly target the heart pump defects in diastolic function. Calcium mishandling is a hallmark of heart disease and has been the subject of a large body of research. ...An alternative approach to address calcium misha …
There are currently no therapies available that directly target the heart pump defects in diastolic function. Calcium mishandling is …
Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes.
Bedada FB, Wheelwright M, Metzger JM. Bedada FB, et al. Among authors: metzger jm. Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1829-38. doi: 10.1016/j.bbamcr.2015.11.005. Epub 2015 Nov 11. Biochim Biophys Acta. 2016. PMID: 26578113 Free PMC article. Review.
Human heart failure due to myocardial infarction is a major health concern. ...This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel....
Human heart failure due to myocardial infarction is a major health concern. ...This article is part of a Special Issue entitled: Card …
Aesthetic cardiology: adipose-derived stem cells for myocardial repair.
Palpant NJ, Metzger JM. Palpant NJ, et al. Among authors: metzger jm. Curr Stem Cell Res Ther. 2010 Jun;5(2):145-52. doi: 10.2174/157488810791268654. Curr Stem Cell Res Ther. 2010. PMID: 19941452 Free PMC article. Review.
Stem cell biology has increasingly gained scientific and public interest in recent years. In particular, the use of stem cells for treatment of heart disease has been strongly pursued within the scientific and medical communities. ...Recent studies have emerged on adipose- …
Stem cell biology has increasingly gained scientific and public interest in recent years. In particular, the use of stem cells for treatment …
Parvalbumin isoforms for enhancing cardiac diastolic function.
Wang W, Metzger JM. Wang W, et al. Among authors: metzger jm. Cell Biochem Biophys. 2008;51(1):1-8. doi: 10.1007/s12013-008-9011-x. Epub 2008 May 6. Cell Biochem Biophys. 2008. PMID: 18458829 Review.
Diastolic heart failure (DHF), characterized by depressed myocardial relaxation performance and poor ventricular filling, is a distinct form of heart failure accounting for nearly half of the heart failure patients with otherwise normal systolic performance. …
Diastolic heart failure (DHF), characterized by depressed myocardial relaxation performance and poor ventricular filling, is a distin …
125 results