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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 6
1954 46
1955 20
1956 33
1957 27
1958 23
1959 15
1960 44
1961 38
1962 77
1963 125
1964 274
1965 200
1966 191
1967 264
1968 322
1969 486
1970 500
1971 520
1972 536
1973 551
1974 563
1975 420
1976 348
1977 302
1978 294
1979 279
1980 266
1981 263
1982 270
1983 250
1984 331
1985 351
1986 321
1987 455
1988 364
1989 416
1990 357
1991 359
1992 402
1993 400
1994 355
1995 333
1996 385
1997 332
1998 411
1999 337
2000 356
2001 374
2002 345
2003 396
2004 411
2005 415
2006 401
2007 421
2008 441
2009 456
2010 497
2011 482
2012 488
2013 485
2014 461
2015 469
2016 446
2017 447
2018 396
2019 344
2020 146
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Search Results

21,317 results
Results by year
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Page 1
Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis.
Timmer A, Patton PH, Chande N, McDonald JW, MacDonald JK. Timmer A, et al. Cochrane Database Syst Rev. 2016 May 18;2016(5):CD000478. doi: 10.1002/14651858.CD000478.pub4. Cochrane Database Syst Rev. 2016. PMID: 27192092 Free PMC article. Review.
OBJECTIVES: To assess the effectiveness and safety of azathioprine and 6-mercaptopurine for maintaining remission of ulcerative colitis. ...One small study found that 6-mercaptopurine was superior to methotrexate for maintenance of remission. In the st …
OBJECTIVES: To assess the effectiveness and safety of azathioprine and 6-mercaptopurine for maintaining remission of ulcerativ …
Optimizing 6-mercaptopurine and azathioprine therapy in the management of inflammatory bowel disease.
Bradford K, Shih DQ. Bradford K, et al. World J Gastroenterol. 2011 Oct 7;17(37):4166-73. doi: 10.3748/wjg.v17.i37.4166. World J Gastroenterol. 2011. PMID: 22072847 Free PMC article. Review.
The thiopurine drugs, 6-mercaptopurine (6-MP) and azathioprine, are efficacious in the arsenal of inflammatory bowel disease (IBD) therapy. ...In this report, we will review different approaches to administer the thiopurine medications, including the administ …
The thiopurine drugs, 6-mercaptopurine (6-MP) and azathioprine, are efficacious in the arsenal of inflammatory bowel di …
Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes.
LaDuke KE, Ehling S, Cullen JM, Bäumer W. LaDuke KE, et al. Am J Vet Res. 2015 Jul;76(7):649-55. doi: 10.2460/ajvr.76.7.649. Am J Vet Res. 2015. PMID: 26111096
OBJECTIVE: To investigate the cytotoxic effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine hepatocytes. SAMPLE: Commercially available cryopreserved canine primary hepatocytes. ...In trial 1, hepatocytes were incubated with azathioprine, …
OBJECTIVE: To investigate the cytotoxic effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine hepatocy …
Why more 6-mercaptopurine?
Kamen BA. Kamen BA. Semin Hematol. 1991 Jul;28(3 Suppl 4):12-4. Semin Hematol. 1991. PMID: 1780746 Review. No abstract available.
Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease.
Chande N, Tsoulis DJ, MacDonald JK. Chande N, et al. Cochrane Database Syst Rev. 2013 Apr 30;(4):CD000545. doi: 10.1002/14651858.CD000545.pub4. Cochrane Database Syst Rev. 2013. PMID: 23633304 Updated. Review.
There was no statistically significant difference in clinical remission rates between azathioprine or 6-mercaptopurine and placebo. ...There was no statistically significant difference in clinical improvement rates between azathioprine or 6-mercaptopurine
There was no statistically significant difference in clinical remission rates between azathioprine or 6-mercaptopurine and pla …
6-mercaptopurine.
[No authors listed] [No authors listed] IARC Monogr Eval Carcinog Risk Chem Hum. 1981 May;26:249-66. IARC Monogr Eval Carcinog Risk Chem Hum. 1981. PMID: 6944262 No abstract available.
The absorption of 6-mercaptopurine from 6-mercaptopurine riboside in rat small intestine: effect of phosphate.
Pennington AM, Bronk JR. Pennington AM, et al. Cancer Chemother Pharmacol. 1995;36(2):136-42. doi: 10.1007/BF00689198. Cancer Chemother Pharmacol. 1995. PMID: 7767950
The rate of vascular appearance of 6-mercaptopurine [0.043 +/- 0.005 mumol min-1 (g dry wt.)-1] from 5 mmol luminal 6-mercaptopurine riboside/l did not differ significantly from that seen with 5 mmol luminal 6-mercaptopurine/l. When the l …
The rate of vascular appearance of 6-mercaptopurine [0.043 +/- 0.005 mumol min-1 (g dry wt.)-1] from 5 mmol luminal 6- …
Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn's disease.
Prefontaine E, Sutherland LR, Macdonald JK, Cepoiu M. Prefontaine E, et al. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD000067. doi: 10.1002/14651858.CD000067.pub2. Cochrane Database Syst Rev. 2009. PMID: 19160175 Updated. Review.
MAIN RESULTS: Seven trials of azathioprine therapy and one of 6-mercaptopurine were included in the review. Azathioprine and 6-mercaptopurine had a positive effect on maintaining remission. ...Higher response rates were obtained with azathioprine than …
MAIN RESULTS: Seven trials of azathioprine therapy and one of 6-mercaptopurine were included in the review. Azathioprine and …
Prevention of mercaptopurine-induced hypoglycemia using allopurinol to reduce methylated thiopurine metabolites.
Miller MB, Brackett J, Schafer ES, Rau RE. Miller MB, et al. Pediatr Blood Cancer. 2019 Apr;66(4):e27577. doi: 10.1002/pbc.27577. Epub 2018 Dec 13. Pediatr Blood Cancer. 2019. PMID: 30548777
Skewing of mercaptopurine (6-MP) metabolism preferentially toward the 6-methylmercaptopurine (6-MMP) metabolite over the antileukemic metabolite 6-thioguanine (6-TGN) is associated with 6-MP-related hepatotoxocity. Allopurinol when …
Skewing of mercaptopurine (6-MP) metabolism preferentially toward the 6-methylmercaptopurine (6-MMP) metabolite …
Formation of 6-thioguanine and 6-mercaptopurine from their 9-alkyl derivatives in mice.
Nelson JA, Vidale E. Nelson JA, et al. Cancer Res. 1986 Jan;46(1):137-40. Cancer Res. 1986. PMID: 3940185 Free article.
Several 9-alkyl, 6-thiopurines have been reported to have more favorable therapeutic indexes than do the parent drugs, 6-mercaptopurine (MP) and 6-thioguanine (TG). ...Dealkylation of 9-(n-butyl)-6-mercaptopurine and 9-ethyl-6-m
Several 9-alkyl, 6-thiopurines have been reported to have more favorable therapeutic indexes than do the parent drugs, 6-me
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