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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 1
1955 3
1956 1
1957 2
1958 4
1959 1
1960 6
1961 3
1962 8
1963 12
1964 25
1965 8
1966 8
1967 18
1968 12
1969 12
1970 22
1971 25
1972 35
1973 45
1974 66
1975 76
1976 69
1977 68
1978 68
1979 70
1980 94
1981 118
1982 128
1983 116
1984 144
1985 145
1986 131
1987 140
1988 108
1989 119
1990 147
1991 118
1992 121
1993 93
1994 90
1995 93
1996 76
1997 68
1998 70
1999 78
2000 61
2001 87
2002 64
2003 93
2004 90
2005 76
2006 76
2007 64
2008 69
2009 69
2010 83
2011 75
2012 71
2013 88
2014 74
2015 52
2016 66
2017 86
2018 94
2019 74
2020 48
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4,265 results
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Page 1
Determination of 6-thioguanine and 6-methylmercaptopurine in dried blood spots using liquid chromatography-tandem mass spectrometry: Method development, validation and clinical application.
Lampič K, Trontelj J, Prosen H, Drobne D, Šmid A, Vovk T. Lampič K, et al. Clin Chim Acta. 2019 Dec;499:24-33. doi: 10.1016/j.cca.2019.08.024. Epub 2019 Aug 23. Clin Chim Acta. 2019. PMID: 31449774
Therefore, a quantitative LC-MS/MS method for determination of 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP) in dried blood spot samples (DBS) was developed. ...RESULTS: Method met the validation criteria in terms of selectivity, linea …
Therefore, a quantitative LC-MS/MS method for determination of 6-thioguanine (6-TG) and 6-methylmercaptopurine ( …
[Progress of Research on 6-Thioguanine versus 6-Mercaptopurine in childhood ALL].
Hou YJ, Zhao L, Liu XX, Ma YY. Hou YJ, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016 Apr;24(2):622-6. doi: 10.7534/j.issn.1009-2137.2016.02.059. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016. PMID: 27151041 Review. Chinese.
It has long been recognized that thiopurines are critical components in the treatment for prevention of recurrence in childhood ALL, the 6-mercaptopurine (6-MP) has usually been used in daily long-term maintenance therapy, and 6-thioguanine (6-T …
It has long been recognized that thiopurines are critical components in the treatment for prevention of recurrence in childhood ALL, the …
6-thioguanine: a drug with unrealized potential for cancer therapy.
Munshi PN, Lubin M, Bertino JR. Munshi PN, et al. Oncologist. 2014 Jul;19(7):760-5. doi: 10.1634/theoncologist.2014-0178. Epub 2014 Jun 13. Oncologist. 2014. PMID: 24928612 Free PMC article. Review.
Sixty years ago, 6-thioguanine (6-TG) was introduced into the clinic. We suggest its full potential in therapy may not have been reached. In this paper, we contrast 6-TG and the more widely used 6-mercaptopurine; discuss 6-TG metabolism, …
Sixty years ago, 6-thioguanine (6-TG) was introduced into the clinic. We suggest its full potential in therapy may not …
6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2.
Chuang SJ, Cheng SC, Tang HC, Sun CY, Chou CY. Chuang SJ, et al. Sci Rep. 2018 Feb 15;8(1):3102. doi: 10.1038/s41598-018-21476-w. Sci Rep. 2018. PMID: 29449607 Free PMC article.
Here a leukemia drug, 6-thioguanine, was found to be a potent inhibitor of USP2. Enzyme-kinetic and X-ray crystallographic data suggest that 6-thioguanine displays a noncompetitive and slow-binding inhibitory mechanism against USP2. Our study provides …
Here a leukemia drug, 6-thioguanine, was found to be a potent inhibitor of USP2. Enzyme-kinetic and X-ray crystallographic dat …
Hepatotoxicity during 6-thioguanine treatment in inflammatory bowel disease and childhood acute lymphoblastic leukaemia: A systematic review.
Toksvang LN, Schmidt MS, Arup S, Larsen RH, Frandsen TL, Schmiegelow K, Rank CU. Toksvang LN, et al. PLoS One. 2019 May 24;14(5):e0212157. doi: 10.1371/journal.pone.0212157. eCollection 2019. PLoS One. 2019. PMID: 31125338 Free PMC article.
BACKGROUND: The recently established association between higher levels of DNA-incorporated thioguanine nucleotides and lower relapse risk in childhood acute lymphoblastic leukaemia (ALL) calls for reassessment of prolonged 6-thioguanine (6TG) treatment, while …
BACKGROUND: The recently established association between higher levels of DNA-incorporated thioguanine nucleotides and lower relapse …
Simultaneous determination of 6-mercaptopruine, 6-thioguanine and dasatinib as three important anticancer drugs using nanostructure voltammetric sensor employing Pt/MWCNTs and 1-butyl-3-methylimidazolium hexafluoro phosphate.
Karimi-Maleh H, Shojaei AF, Tabatabaeian K, Karimi F, Shakeri S, Moradi R. Karimi-Maleh H, et al. Biosens Bioelectron. 2016 Dec 15;86:879-884. doi: 10.1016/j.bios.2016.07.086. Epub 2016 Jul 26. Biosens Bioelectron. 2016. PMID: 27494812
6-Mercaptopurine, 6-thioguanine and dasatinib are three important anticancer drugs with high adverse effects in human body. In this study, a Pt/MWCNTs-1-butyl-3-methylimidazolium hexafluoro phosphate-modified carbon paste electrode was developed for the simul
6-Mercaptopurine, 6-thioguanine and dasatinib are three important anticancer drugs with high adverse effects in human b
A Systematic Review and Meta-Analysis of 6-Thioguanine Nucleotide Levels and Clinical Remission in Inflammatory Bowel Disease.
Estevinho MM, Afonso J, Rosa I, Lago P, Trindade E, Correia L, Dias CC, Magro F; GEDII [Portuguese IBD Group]. Estevinho MM, et al. J Crohns Colitis. 2017 Oct 27;11(11):1381-1392. doi: 10.1093/ecco-jcc/jjx089. J Crohns Colitis. 2017. PMID: 28981590 Review.
This systematic review and meta-analysis aimed: i] to assess the clinical value of 6-thioguanine nucleotide thresholds; and ii] to compare mean 6-thioguanine nucleotide concentrations between patients in clinical remission vs. those with active disease …
This systematic review and meta-analysis aimed: i] to assess the clinical value of 6-thioguanine nucleotide thresholds; and ii …
Comparison of 6-mercaptopurine with 6-thioguanine for the analysis of thiopurine S-methyltransferase activity in human erythrocyte by LC-MS/MS.
Mei S, Li X, Gong X, Zhang X, Li X, Yang L, Zhu L, Zhou H, Liu Y, Zhou A, Zhang X, Zhao Z. Mei S, et al. Biomed Chromatogr. 2017 Sep;31(9). doi: 10.1002/bmc.3959. Epub 2017 Mar 29. Biomed Chromatogr. 2017. PMID: 28212467
Evaluation of thiopurine S-methyltransferase activity (TPMT), a major determinant of TPD toxicity, before TPD treatment using 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) as substrate was suggested. ...A computer-based simulation indicated t …
Evaluation of thiopurine S-methyltransferase activity (TPMT), a major determinant of TPD toxicity, before TPD treatment using 6-merca …
Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes.
LaDuke KE, Ehling S, Cullen JM, Bäumer W. LaDuke KE, et al. Am J Vet Res. 2015 Jul;76(7):649-55. doi: 10.2460/ajvr.76.7.649. Am J Vet Res. 2015. PMID: 26111096
OBJECTIVE: To investigate the cytotoxic effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine hepatocytes. SAMPLE: Commercially available cryopreserved canine primary hepatocytes. ...In trial 1, hepatocytes were incubated with azathioprine, …
OBJECTIVE: To investigate the cytotoxic effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine hepatocy …
Simple and selective determination of 6-thioguanine by using polyethylenimine (PEI) functionalized carbon dots.
Zeng H, Li L, Ding Y, Zhuang Q. Zeng H, et al. Talanta. 2018 Feb 1;178:879-885. doi: 10.1016/j.talanta.2017.09.087. Epub 2017 Oct 20. Talanta. 2018. PMID: 29136909
In this work, a new selective and simple fluorescence probe based on polyethylenimine(PEI) functionalized carbon dots (PEI-CDs) for fast determination of 6-thioguanine (6-TG) was developed. ...The fluorescence intensity of PEI-CDs decreased obviously with gra …
In this work, a new selective and simple fluorescence probe based on polyethylenimine(PEI) functionalized carbon dots (PEI-CDs) for fast det …
4,265 results
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