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Table representation of search results timeline featuring number of search results per year.

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1995 1
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1999 1
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2003 3
2004 1
2005 12
2006 13
2007 12
2008 15
2009 18
2010 26
2011 27
2012 44
2013 37
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2019 49
2020 40
2021 3
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LINC02273 drives breast cancer metastasis by epigenetically increasing AGR2 transcription.
Xiu B, Chi Y, Liu L, Chi W, Zhang Q, Chen J, Guo R, Si J, Li L, Xue J, Shao ZM, Wu ZH, Huang S, Wu J. Xiu B, et al. Mol Cancer. 2019 Dec 19;18(1):187. doi: 10.1186/s12943-019-1115-y. Mol Cancer. 2019. PMID: 31856843 Free PMC article.
Mechanistically, hnRNPL-LINC02273 formed a complex which activated AGR2 transcription and promoted cancer metastasis. The recruitment of hnRNPL-LINC02273 complex to AGR2 promoter region epigenetically upregulated AGR2 by augmenting local H3K4me3 and H3K27ac l …
Mechanistically, hnRNPL-LINC02273 formed a complex which activated AGR2 transcription and promoted cancer metastasis. The recruitment …
Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation.
Maurel M, Obacz J, Avril T, Ding YP, Papadodima O, Treton X, Daniel F, Pilalis E, Hörberg J, Hou W, Beauchamp MC, Tourneur-Marsille J, Cazals-Hatem D, Sommerova L, Samali A, Tavernier J, Hrstka R, Dupont A, Fessart D, Delom F, Fernandez-Zapico ME, Jansen G, Eriksson LA, Thomas DY, Jerome-Majewska L, Hupp T, Chatziioannou A, Chevet E, Ogier-Denis E. Maurel M, et al. EMBO Mol Med. 2019 Jun;11(6):e10120. doi: 10.15252/emmm.201810120. EMBO Mol Med. 2019. PMID: 31040128 Free PMC article.
Although these biological effects are well established, the underlying molecular mechanisms of AGR2 function toward inflammation remain poorly defined. Here, using a protein-protein interaction screen to identify cellular regulators of AGR2 dimerization, we unveiled …
Although these biological effects are well established, the underlying molecular mechanisms of AGR2 function toward inflammation rema …
Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab.
Wang D, Xu Q, Yuan Q, Jia M, Niu H, Liu X, Zhang J, Young CY, Yuan H. Wang D, et al. Oncogene. 2019 May;38(18):3458-3474. doi: 10.1038/s41388-019-0675-z. Epub 2019 Jan 15. Oncogene. 2019. PMID: 30647455 Free PMC article.
The mechanisms controlling AGR2 abundance in cancer remain largely unknown. Here, we observed that AGR2 expression is significantly suppressed by proteasome inhibitor MG132/bortezomib at mRNA and protein levels in lung cancer cells. ...Importantly, downregulation of …
The mechanisms controlling AGR2 abundance in cancer remain largely unknown. Here, we observed that AGR2 expression is signific …
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system.
Pelaseyed T, Bergström JH, Gustafsson JK, Ermund A, Birchenough GM, Schütte A, van der Post S, Svensson F, Rodríguez-Piñeiro AM, Nyström EE, Wising C, Johansson ME, Hansson GC. Pelaseyed T, et al. Immunol Rev. 2014 Jul;260(1):8-20. doi: 10.1111/imr.12182. Immunol Rev. 2014. PMID: 24942678 Free PMC article. Review.
The intestinal goblet cells secrete not only the MUC2 mucin but also a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3. The goblet cells have recently been shown to have a novel gate-keeping role for the presentation of oral antigens to the immune sy …
The intestinal goblet cells secrete not only the MUC2 mucin but also a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, …
Anterior Gradient 3 Promotes Breast Cancer Development and Chemotherapy Response.
Xu Q, Shao Y, Zhang J, Zhang H, Zhao Y, Liu X, Guo Z, Chong W, Gu F, Ma Y. Xu Q, et al. Cancer Res Treat. 2020 Jan;52(1):218-245. doi: 10.4143/crt.2019.217. Epub 2019 Jul 8. Cancer Res Treat. 2020. PMID: 31291711 Free PMC article.
PURPOSE: Anterior gradient 3 (AGR3) belongs to human anterior gradient (AGR) family. The function of AGR3 on cancer remains unknown. ...AGR3's correlations with clinicopathological features and prognosis of IDC patients were analyzed. ...
PURPOSE: Anterior gradient 3 (AGR3) belongs to human anterior gradient (AGR) family. The function of AGR3 on cancer remains un …
Single-cell proteomics reveals changes in expression during hair-cell development.
Zhu Y, Scheibinger M, Ellwanger DC, Krey JF, Choi D, Kelly RT, Heller S, Barr-Gillespie PG. Zhu Y, et al. Elife. 2019 Nov 4;8:e50777. doi: 10.7554/eLife.50777. Elife. 2019. PMID: 31682227 Free PMC article.
., OCM, CRABP1, GPX2, AK1, GSTO1) and those that decreased during differentiation (e.g., TMSB4X, AGR3). Complementary single-cell transcriptome profiling showed corresponding changes in mRNA during maturation of hair cells. ...
., OCM, CRABP1, GPX2, AK1, GSTO1) and those that decreased during differentiation (e.g., TMSB4X, AGR3). Complementary single-cell tra …
Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.
Tiemann K, Garri C, Lee SB, Malihi PD, Park M, Alvarez RM, Yap LP, Mallick P, Katz JE, Gross ME, Kani K. Tiemann K, et al. Oncogene. 2019 Apr;38(16):3003-3018. doi: 10.1038/s41388-018-0638-9. Epub 2018 Dec 21. Oncogene. 2019. PMID: 30575818 Free PMC article.
AGR2 has also been characterized as a proto-oncogene and a potential cancer biomarker. Cellular localization of AGR2 is emerging as a key component for understanding the role of AGR2 as a proto-oncogene. ...
AGR2 has also been characterized as a proto-oncogene and a potential cancer biomarker. Cellular localization of AGR2 is emergi
Secretion of pro-oncogenic AGR2 protein in cancer.
Moidu NA, A Rahman NS, Syafruddin SE, Low TY, Mohtar MA. Moidu NA, et al. Heliyon. 2020 Sep 23;6(9):e05000. doi: 10.1016/j.heliyon.2020.e05000. eCollection 2020 Sep. Heliyon. 2020. PMID: 33005802 Free PMC article. Review.
AGR2 promotes tumour development and metastasis and its elevated expression is almost completely restricted to malignant tumours. ...We also discussed the possible mechanisms of AGR2 secretion as well as deliberating the functional impacts of AGR2 in cancer s
AGR2 promotes tumour development and metastasis and its elevated expression is almost completely restricted to malignant tumours. ...
ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation.
Dumartin L, Alrawashdeh W, Trabulo SM, Radon TP, Steiger K, Feakins RM, di Magliano MP, Heeschen C, Esposito I, Lemoine NR, Crnogorac-Jurcevic T. Dumartin L, et al. Oncogene. 2017 Jun 1;36(22):3094-3103. doi: 10.1038/onc.2016.459. Epub 2016 Dec 12. Oncogene. 2017. PMID: 27941872 Free PMC article.
Moreover, AGR2 was also found in discrete subpopulations of non-transformed cells neighbouring these pre-neoplastic lesions. ...In LSL-Kras(G12D);Pdx1-Cre (KC) mouse model Agr2 induction preceded the formation of pre-neoplastic lesions and their development was larg …
Moreover, AGR2 was also found in discrete subpopulations of non-transformed cells neighbouring these pre-neoplastic lesions. ...In LS …
The role of AGR2 and AGR3 in cancer: similar but not identical.
Obacz J, Takacova M, Brychtova V, Dobes P, Pastorekova S, Vojtesek B, Hrstka R. Obacz J, et al. Eur J Cell Biol. 2015 Mar-Apr;94(3-4):139-47. doi: 10.1016/j.ejcb.2015.01.002. Epub 2015 Jan 21. Eur J Cell Biol. 2015. PMID: 25666661 Review.
While AGR2 has been widely demonstrated as a metastasis-related protein whose elevated expression predicts worse patient outcome, little is known about AGR3's role in tumour biology. Thus, we aim to confront the issue of AGR3 function in physiology and pathol …
While AGR2 has been widely demonstrated as a metastasis-related protein whose elevated expression predicts worse patient outcome, lit …
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