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The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system.
Pelaseyed T, Bergström JH, Gustafsson JK, Ermund A, Birchenough GM, Schütte A, van der Post S, Svensson F, Rodríguez-Piñeiro AM, Nyström EE, Wising C, Johansson ME, Hansson GC. Pelaseyed T, et al. Immunol Rev. 2014 Jul;260(1):8-20. doi: 10.1111/imr.12182. Immunol Rev. 2014. PMID: 24942678 Free PMC article. Review.
The intestinal goblet cells secrete not only the MUC2 mucin but also a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3. The goblet cells have recently been shown to have a novel gate-keeping role for the presentation of oral antigens to the immune sy …
The intestinal goblet cells secrete not only the MUC2 mucin but also a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, …
Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease.
Zheng W, Rosenstiel P, Huse K, Sina C, Valentonyte R, Mah N, Zeitlmann L, Grosse J, Ruf N, Nürnberg P, Costello CM, Onnie C, Mathew C, Platzer M, Schreiber S, Hampe J. Zheng W, et al. Genes Immun. 2006 Jan;7(1):11-8. doi: 10.1038/sj.gene.6364263. Genes Immun. 2006. PMID: 16222343
Linkage analyses have implicated chromosome 7p21.3 as a susceptibility region for inflammatory bowel disease (IBD). Recently, the mouse phenotype with diarrhea and goblet cell dysfunction caused by anterior gradient protein 2 dysfunction was reported (Europea …
Linkage analyses have implicated chromosome 7p21.3 as a susceptibility region for inflammatory bowel disease (IBD). Rec …
Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation.
Maurel M, Obacz J, Avril T, Ding YP, Papadodima O, Treton X, Daniel F, Pilalis E, Hörberg J, Hou W, Beauchamp MC, Tourneur-Marsille J, Cazals-Hatem D, Sommerova L, Samali A, Tavernier J, Hrstka R, Dupont A, Fessart D, Delom F, Fernandez-Zapico ME, Jansen G, Eriksson LA, Thomas DY, Jerome-Majewska L, Hupp T, Chatziioannou A, Chevet E, Ogier-Denis E. Maurel M, et al. EMBO Mol Med. 2019 Jun;11(6):e10120. doi: 10.15252/emmm.201810120. EMBO Mol Med. 2019. PMID: 31040128 Free PMC article.
Mouse AGR2 deletion increases intestinal inflammation and promotes the development of inflammatory bowel disease (IBD). ...We also demonstrate that in IBD and specifically in Crohn's disease, the levels of AGR2 dimerization modulators are …
Mouse AGR2 deletion increases intestinal inflammation and promotes the development of inflammatory bowel disease
Endoplasmic reticulum stress and inflammatory bowel disease.
Niederreiter L, Kaser A. Niederreiter L, et al. Acta Gastroenterol Belg. 2011 Jun;74(2):330-3. Acta Gastroenterol Belg. 2011. PMID: 21861319 Free article. Review.
Endoplasmic reticulum (ER) stress arises from the accumulation of misfolded or unfolded proteins in the ER and elicits the unfolded protein response (UPR), an adaptive signalling pathway which aims at resolving ER stress. Genetic loci that confer risk for both forms of inflamm
Endoplasmic reticulum (ER) stress arises from the accumulation of misfolded or unfolded proteins in the ER and elicits the unfolded protein …
Mechanisms of anterior gradient-2 regulation and function in cancer.
Brychtova V, Mohtar A, Vojtesek B, Hupp TR. Brychtova V, et al. Semin Cancer Biol. 2015 Aug;33:16-24. doi: 10.1016/j.semcancer.2015.04.005. Epub 2015 Apr 30. Semin Cancer Biol. 2015. PMID: 25937245 Review.
AGR2 perturbation in mammals influences disease processes including cancer progression and drug resistance, asthma, and inflammatory bowel disease. This review will focus on the molecular characteristics, function, and regulation of AGR2,
AGR2 perturbation in mammals influences disease processes including cancer progression and drug resistance, asthma, and inf
Emerging roles for the pro-oncogenic anterior gradient-2 in cancer development.
Chevet E, Fessart D, Delom F, Mulot A, Vojtesek B, Hrstka R, Murray E, Gray T, Hupp T. Chevet E, et al. Oncogene. 2013 May 16;32(20):2499-509. doi: 10.1038/onc.2012.346. Epub 2012 Sep 3. Oncogene. 2013. PMID: 22945652 Review.
Signalling hubs that mediate such phenotype have been identified largely using OMICS platforms that measure dynamic molecular changes within the cancer cell landscape. The pro-oncogenic protein anterior gradient 2 (AGR2) is a case in point; AGR2 has been shown using …
Signalling hubs that mediate such phenotype have been identified largely using OMICS platforms that measure dynamic molecular changes within …
The unfolded protein response and gastrointestinal disease.
Kaser A, Adolph TE, Blumberg RS. Kaser A, et al. Semin Immunopathol. 2013 May;35(3):307-19. doi: 10.1007/s00281-013-0377-5. Epub 2013 Apr 16. Semin Immunopathol. 2013. PMID: 23588234 Free PMC article. Review.
Genetic deletion of factors involved in the unfolded protein response (UPR), which functions in the resolution of ER stress that arises from misfolded proteins, result in spontaneous intestinal inflammation closely mimicking human inflammatory bowel disease ( …
Genetic deletion of factors involved in the unfolded protein response (UPR), which functions in the resolution of ER stress that arises from …
AGR2 ameliorates tumor necrosis factor-alpha-induced epithelial barrier dysfunction via suppression of NF-kappaB p65-mediated MLCK/p-MLC pathway activation.
Ye X, Sun M. Ye X, et al. Int J Mol Med. 2017 May;39(5):1206-1214. doi: 10.3892/ijmm.2017.2928. Epub 2017 Mar 21. Int J Mol Med. 2017. PMID: 28339048 Free PMC article.
Intestinal epithelial barrier dysfunction plays a critical role in the pathogenesis of inflammatory bowel disease (IBD). Anterior gradient protein 2 homologue (AGR2) assists in maintaining intestinal homeostasis in dextran sulphate sodium-induced mouse …
Intestinal epithelial barrier dysfunction plays a critical role in the pathogenesis of inflammatory bowel disease (IBD) …
Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice.
Zhao F, Edwards R, Dizon D, Afrasiabi K, Mastroianni JR, Geyfman M, Ouellette AJ, Andersen B, Lipkin SM. Zhao F, et al. Dev Biol. 2010 Feb 15;338(2):270-9. doi: 10.1016/j.ydbio.2009.12.008. Epub 2009 Dec 16. Dev Biol. 2010. PMID: 20025862 Free PMC article.
Anterior Gradient 2 (AGR2) is a protein disulfide isomerase that plays important roles in diverse processes in multiple cell lineages as a developmental regulator, survival factor and susceptibility gene for inflammatory bowel disease. ...These studies …
Anterior Gradient 2 (AGR2) is a protein disulfide isomerase that plays important roles in diverse processes in multiple cell lineages …
Foxa2 and Hif1ab regulate maturation of intestinal goblet cells by modulating agr2 expression in zebrafish embryos.
Lai YR, Lu YF, Lien HW, Huang CJ, Hwang SP. Lai YR, et al. Biochem J. 2016 Jul 15;473(14):2205-18. doi: 10.1042/BCJ20160392. Epub 2016 May 24. Biochem J. 2016. PMID: 27222589
Mammalian anterior gradient 2 (AGR2), an endoplasmic reticulum (ER) protein disulfide-isomerase (PDI), is involved in cancer cell growth and metastasis, asthma and inflammatory bowel disease (IBD). ...Despite its importance in cancer biology and inf
Mammalian anterior gradient 2 (AGR2), an endoplasmic reticulum (ER) protein disulfide-isomerase (PDI), is involved in cancer cell gro …
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