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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2006 1
2007 13
2008 34
2009 34
2010 35
2011 30
2012 38
2013 38
2014 33
2015 26
2016 17
2017 23
2018 23
2019 15
2020 13
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Page 1
A comprehensive review and update on Crohn's disease.
Gajendran M, Loganathan P, Catinella AP, Hashash JG. Gajendran M, et al. Dis Mon. 2018 Feb;64(2):20-57. doi: 10.1016/j.disamonth.2017.07.001. Epub 2017 Aug 18. Dis Mon. 2018. PMID: 28826742 Review.
The term inflammatory bowel disease (IBD) refers principally to two major categories of chronic relapsing inflammatory intestinal disorders: Crohn's disease (CD) and ulcerative colitis (UC). ...The most common scoring systems used to measure clinical disea
The term inflammatory bowel disease (IBD) refers principally to two major categories of chronic relapsing inflammatory intestinal dis …
ATG16L1: A multifunctional susceptibility factor in Crohn disease.
Salem M, Ammitzboell M, Nys K, Seidelin JB, Nielsen OH. Salem M, et al. Autophagy. 2015 Apr 3;11(4):585-94. doi: 10.1080/15548627.2015.1017187. Autophagy. 2015. PMID: 25906181 Free PMC article. Review.
The most common and well-studied genetic variant of ATG16L1 (rs2241880; leading to a T300A conversion) exhibits a strong association with risk for developing Crohn disease. ...In this review, we focus on the importance of ATG16L1 and its genetic varian …
The most common and well-studied genetic variant of ATG16L1 (rs2241880; leading to a T300A conversion) exhibits a strong association …
Genetic polymorphisms of ATG16L1 and IRGM genes in Malaysian patients with Crohn's disease.
Kee BP, Ng JG, Ng CC, Hilmi I, Goh KL, Chua KH. Kee BP, et al. J Dig Dis. 2020 Jan;21(1):29-37. doi: 10.1111/1751-2980.12829. Epub 2019 Dec 2. J Dig Dis. 2020. PMID: 31654602
OBJECTIVE: To investigate the association between genetic polymorphisms in ATG16L1 and IRGM genes and the development of Crohn's disease (CD) in Malaysian patients. ...RESULTS: Two SNPs (rs2241880 and rs6754677) in the ATG16L1 gene were significantly a …
OBJECTIVE: To investigate the association between genetic polymorphisms in ATG16L1 and IRGM genes and the development of Crohn
The Crohn's disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response.
Lavoie S, Conway KL, Lassen KG, Jijon HB, Pan H, Chun E, Michaud M, Lang JK, Gallini Comeau CA, Dreyfuss JM, Glickman JN, Vlamakis H, Ananthakrishnan A, Kostic A, Garrett WS, Xavier RJ. Lavoie S, et al. Elife. 2019 Jan 22;8:e39982. doi: 10.7554/eLife.39982. Elife. 2019. PMID: 30666959 Free PMC article.
The Crohn's disease risk allele ATG16L1 T300A results in abnormal Paneth cells due to decreased selective autophagy, increased cytokine release, and decreased intracellular bacterial clearance. ...Changes occur before disease onset, suggesting that …
The Crohn's disease risk allele ATG16L1 T300A results in abnormal Paneth cells due to decreased selective autophagy, in …
A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3.
Murthy A, Li Y, Peng I, Reichelt M, Katakam AK, Noubade R, Roose-Girma M, DeVoss J, Diehl L, Graham RR, van Lookeren Campagne M. Murthy A, et al. Nature. 2014 Feb 27;506(7489):456-62. doi: 10.1038/nature13044. Epub 2014 Feb 19. Nature. 2014. PMID: 24553140
Crohn's disease is a debilitating inflammatory bowel disease (IBD) that can involve the entire digestive tract. A single-nucleotide polymorphism (SNP) encoding a missense variant in the autophagy gene ATG16L1 (rs2241880, Thr300Ala) is strongly associat
Crohn's disease is a debilitating inflammatory bowel disease (IBD) that can involve the entire digestive tract. A singl
Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.
Tschurtschenthaler M, Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak MB, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, Harding HP, Smith AM, Peppelenbosch MP, Targan SR, Ron D, Rosenstiel P, Blumberg RS, Kaser A. Tschurtschenthaler M, et al. J Exp Med. 2017 Feb;214(2):401-422. doi: 10.1084/jem.20160791. Epub 2017 Jan 12. J Exp Med. 2017. PMID: 28082357 Free PMC article.
ATG16L1(T300A), a major risk polymorphism in Crohn's disease (CD), causes impaired autophagy, but it has remained unclear how this predisposes to CD. ...IRE1α accumulates in Paneth cells of Atg16l1(ΔIEC) mice, and humans homozygous for ATG16L1(T
ATG16L1(T300A), a major risk polymorphism in Crohn's disease (CD), causes impaired autophagy, but it has remained uncle
Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1.
Khor B, Conway KL, Omar AS, Biton M, Haber AL, Rogel N, Baxt LA, Begun J, Kuballa P, Gagnon JD, Lassen KG, Regev A, Xavier RJ. Khor B, et al. J Immunol. 2019 Oct 1;203(7):1820-1829. doi: 10.4049/jimmunol.1800419. Epub 2019 Aug 26. J Immunol. 2019. PMID: 31451676
ATG16L1 has been particularly well studied in knockout and hypomorph settings as well as models recapitulating the Crohn disease-associated T300A polymorphism. Interestingly, ATG16L1 has a single homolog, ATG16L2, which is independently implicated in d
ATG16L1 has been particularly well studied in knockout and hypomorph settings as well as models recapitulating the Crohn di
ATG16L1 T300A polymorphism is associated with Crohn's disease in a Northwest Greek cohort, but ECM1 T130M and G290S polymorphisms are not associated with ulcerative colitis.
Tsianos VE, Kostoulas C, Gazouli M, Frillingos S, Georgiou I, Christodoulou DK, Katsanos KH, Tsianos EV. Tsianos VE, et al. Ann Gastroenterol. 2020 Jan-Feb;33(1):38-44. doi: 10.20524/aog.2019.0434. Epub 2019 Nov 21. Ann Gastroenterol. 2020. PMID: 31892796 Free PMC article.
BACKGROUND: Crohn's disease (CD) and ulcerative colitis (UC) are well-described disease entities with unknown etiopathogenesis. ...The role of susceptibility gene polymorphisms, such as ATG16L1 T300A and ECM1 T130M and G290S, is well-described, althoug …
BACKGROUND: Crohn's disease (CD) and ulcerative colitis (UC) are well-described disease entities with unknown etiopatho …
Autophagy and Crohn's disease.
Nguyen HT, Lapaquette P, Bringer MA, Darfeuille-Michaud A. Nguyen HT, et al. J Innate Immun. 2013;5(5):434-43. doi: 10.1159/000345129. Epub 2013 Jan 15. J Innate Immun. 2013. PMID: 23328432 Free PMC article. Review.
Advances in genetics have shed light on the molecular basis of Crohn's disease (CD) predisposition and pathogenesis, via linkage disequilibrium analysis to genome-wide association studies. ...Remarkably, polymorphisms in autophagy genes, such as ATG16L1 and I …
Advances in genetics have shed light on the molecular basis of Crohn's disease (CD) predisposition and pathogenesis, via linka …
CNTNAP3 associated ATG16L1 expression and Crohn's disease.
Qiao YQ, Huang ML, Zheng Q, Wang TR, Xu AT, Cao Y, Zhao D, Ran ZH, Shen J. Qiao YQ, et al. Mediators Inflamm. 2015;2015:404185. doi: 10.1155/2015/404185. Epub 2015 Mar 26. Mediators Inflamm. 2015. PMID: 25883416 Free PMC article.
Autophagy-related gene mutations and autophagy disorders are important in Crohn's disease (CD). The nucleotide oligomerization domain 2-autophagy genes autophagy 16-like 1 (NOD2-ATG16L1) signaling axis disorder contributes to the dysfunction of autophagy. Thi …
Autophagy-related gene mutations and autophagy disorders are important in Crohn's disease (CD). The nucleotide oligomerization …
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