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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 1
1981 3
1982 3
1983 2
1985 1
1990 2
1994 1
1998 1
1999 5
2000 16
2001 22
2002 31
2003 40
2004 37
2005 37
2006 43
2007 47
2008 32
2009 38
2010 39
2011 40
2012 49
2013 68
2014 61
2015 69
2016 72
2017 82
2018 68
2019 73
2020 64
2021 8
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929 results
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Page 1
Progressive familial intrahepatic cholestasis.
Srivastava A. Srivastava A. J Clin Exp Hepatol. 2014 Mar;4(1):25-36. doi: 10.1016/j.jceh.2013.10.005. Epub 2013 Nov 23. J Clin Exp Hepatol. 2014. PMID: 25755532 Free PMC article. Review.
The defect is in ATP8B1 gene encoding the FIC1 protein, ABCB 11 gene encoding BSEP protein and ABCB4 gene encoding MDR3 protein in PFIC1, 2 and 3 respectively. ...
The defect is in ATP8B1 gene encoding the FIC1 protein, ABCB 11 gene encoding BSEP protein and ABCB4 gene encoding MDR3 protein in PF …
Drugs and hepatic transporters: A review.
Jetter A, Kullak-Ublick GA. Jetter A, et al. Pharmacol Res. 2020 Apr;154:104234. doi: 10.1016/j.phrs.2019.04.018. Epub 2019 Apr 17. Pharmacol Res. 2020. PMID: 31004787 Review.
Since bile acids and their salts are toxic detergents for hepatocytes, they have to be eliminated efficiently. This task is accomplished by the bile salt export pump BSEP. Two further transporters, MDR3 and ATP8B1 are involved in the proper constitution of bile. ...Additio …
Since bile acids and their salts are toxic detergents for hepatocytes, they have to be eliminated efficiently. This task is accomplished by …
An Update on Drug-induced Liver Injury.
Devarbhavi H. Devarbhavi H. J Clin Exp Hepatol. 2012 Sep;2(3):247-59. doi: 10.1016/j.jceh.2012.05.002. Epub 2012 Sep 21. J Clin Exp Hepatol. 2012. PMID: 25755441 Free PMC article. Review.
Intrahepatic Cholestasis in Pregnancy: Review of the Literature.
Piechota J, Jelski W. Piechota J, et al. J Clin Med. 2020 May 6;9(5):1361. doi: 10.3390/jcm9051361. J Clin Med. 2020. PMID: 32384779 Free PMC article. Review.
Elevated levels of gestational hormones and genetic predispositions are important factors for the development of ICP; among the latter, mutations in hepatobiliary transport proteins (multidrug resistance protein 3-MDR3, bile salt export pump- BSEP) play a major role. Clini …
Elevated levels of gestational hormones and genetic predispositions are important factors for the development of ICP; among the latter, muta …
Drug-induced Cholestasis: Mechanisms, Models, and Markers.
Chatterjee S, Annaert P. Chatterjee S, et al. Curr Drug Metab. 2018;19(10):808-818. doi: 10.2174/1389200219666180427165035. Curr Drug Metab. 2018. PMID: 29708070 Review.
Increased insight into susceptibility factors in addition to Bile Salt Export Pump (BSEP) inhibition, biomarkers and involvement of immune system decreased knowledge gaps. ...
Increased insight into susceptibility factors in addition to Bile Salt Export Pump (BSEP) inhibition, biomarkers and involvement of i …
Hepatotoxicity Related to Anti-tuberculosis Drugs: Mechanisms and Management.
Ramappa V, Aithal GP. Ramappa V, et al. J Clin Exp Hepatol. 2013 Mar;3(1):37-49. doi: 10.1016/j.jceh.2012.12.001. Epub 2012 Dec 20. J Clin Exp Hepatol. 2013. PMID: 25755470 Free PMC article. Review.
Combined obeticholic acid and apoptosis inhibitor treatment alleviates liver fibrosis.
Zhou J, Huang N, Guo Y, Cui S, Ge C, He Q, Pan X, Wang G, Wang H, Hao H. Zhou J, et al. Acta Pharm Sin B. 2019 May;9(3):526-536. doi: 10.1016/j.apsb.2018.11.004. Epub 2018 Nov 27. Acta Pharm Sin B. 2019. PMID: 31193776 Free PMC article.
Role of farnesoid X receptor and bile acids in alcoholic liver disease.
Manley S, Ding W. Manley S, et al. Acta Pharm Sin B. 2015 Mar;5(2):158-67. doi: 10.1016/j.apsb.2014.12.011. Epub 2015 Mar 9. Acta Pharm Sin B. 2015. PMID: 26579442 Free PMC article. Review.
Sequencing of FIC1, BSEP and MDR3 in a large cohort of patients with cholestasis revealed a high number of different genetic variants.
Dröge C, Bonus M, Baumann U, Klindt C, Lainka E, Kathemann S, Brinkert F, Grabhorn E, Pfister ED, Wenning D, Fichtner A, Gotthardt DN, Weiss KH, McKiernan P, Puri RD, Verma IC, Kluge S, Gohlke H, Schmitt L, Kubitz R, Häussinger D, Keitel V. Dröge C, et al. J Hepatol. 2017 Dec;67(6):1253-1264. doi: 10.1016/j.jhep.2017.07.004. Epub 2017 Jul 19. J Hepatol. 2017. PMID: 28733223
Minor allele frequencies of common polymorphisms in BSEP and MDR3 varied in our cohort compared to the general population, as described by gnomAD. ...LAY SUMMARY: FIC1, BSEP, and MDR3 represent hepatobiliary transport proteins essential for bile formation. ...
Minor allele frequencies of common polymorphisms in BSEP and MDR3 varied in our cohort compared to the general population, as describ …
Severe bile salt export pump deficiency: 82 different ABCB11 mutations in 109 families.
Strautnieks SS, Byrne JA, Pawlikowska L, Cebecauerová D, Rayner A, Dutton L, Meier Y, Antoniou A, Stieger B, Arnell H, Ozçay F, Al-Hussaini HF, Bassas AF, Verkade HJ, Fischler B, Németh A, Kotalová R, Shneider BL, Cielecka-Kuszyk J, McClean P, Whitington PF, Sokal E, Jirsa M, Wali SH, Jankowska I, Pawłowska J, Mieli-Vergani G, Knisely AS, Bull LN, Thompson RJ. Strautnieks SS, et al. Gastroenterology. 2008 Apr;134(4):1203-14. doi: 10.1053/j.gastro.2008.01.038. Epub 2008 Jan 18. Gastroenterology. 2008. PMID: 18395098 Free article.
On immunohistochemical analysis (88 patients), 93% had abnormal or absent BSEP staining. Expression varied most for E297G and D482G, with some BSEP detected in 45% of patients (19/42) with these mutations. ...CONCLUSIONS: With this study, >100 ABCB11 mutations ar …
On immunohistochemical analysis (88 patients), 93% had abnormal or absent BSEP staining. Expression varied most for E297G and D482G, …
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