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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
1997 8
1998 7
1999 17
2000 23
2001 33
2002 51
2003 48
2004 47
2005 53
2006 47
2007 44
2008 48
2009 87
2010 109
2011 135
2012 114
2013 120
2014 118
2015 136
2016 123
2017 156
2018 116
2019 133
2020 126
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1,695 results
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Page 1
The CCL20 and CCR6 axis in psoriasis.
Furue K, Ito T, Tsuji G, Nakahara T, Furue M. Furue K, et al. Scand J Immunol. 2020 Mar;91(3):e12846. doi: 10.1111/sji.12846. Epub 2019 Nov 24. Scand J Immunol. 2020. PMID: 31692008 Review.
IL-17A stimulates epidermal keratinocytes to produce CCL20, which eventually recruits CCR6 + Th17 cells into the lesional skin. Thus, the CCL20/CCR6 axis works as a driving force that prepares an IL-17A-rich cutaneous milieu. In this review, we summarize the current …
IL-17A stimulates epidermal keratinocytes to produce CCL20, which eventually recruits CCR6 + Th17 cells into the lesional skin. Thus, …
Increased plasticity of non-classic Th1 cells toward the Th17 phenotype.
Leipe J, Pirronello F, Klose A, Schulze-Koops H, Skapenko A. Leipe J, et al. Mod Rheumatol. 2020 Sep;30(5):930-936. doi: 10.1080/14397595.2019.1667473. Epub 2019 Oct 17. Mod Rheumatol. 2020. PMID: 31512538
Viable Th1 cells (IFNγ+IL-17-) were sorted into classic Th1 (CD161-CCR6-) and non-classic Th1 (CD161+CCR6+) cells, trans-differentiated under different Th cell-inducing conditions, and assessed for plastic changes by analyzing the Th cell-associated cytokine and tra …
Viable Th1 cells (IFNγ+IL-17-) were sorted into classic Th1 (CD161-CCR6-) and non-classic Th1 (CD161+CCR6+) cells, trans-diffe …
The CCR6-CCL20 axis in humoral immunity and T-B cell immunobiology.
Lee AYS, Körner H. Lee AYS, et al. Immunobiology. 2019 May;224(3):449-454. doi: 10.1016/j.imbio.2019.01.005. Epub 2019 Feb 8. Immunobiology. 2019. PMID: 30772094 Review.
B cells up-regulate CCR6 after activation in secondary lymphoid organs; however, its function is still unclear. In an important insight, the CCR6-CCL20 chemokine axis has been implicated in the regulation of effective humoral responses - disruption of this pair led …
B cells up-regulate CCR6 after activation in secondary lymphoid organs; however, its function is still unclear. In an important insig …
CCR6 signaling inhibits suppressor function of induced-Treg during gut inflammation.
Kulkarni N, Meitei HT, Sonar SA, Sharma PK, Mujeeb VR, Srivastava S, Boppana R, Lal G. Kulkarni N, et al. J Autoimmun. 2018 Mar;88:121-130. doi: 10.1016/j.jaut.2017.10.013. Epub 2017 Nov 7. J Autoimmun. 2018. PMID: 29126851
CCR6 is a G protein-coupled receptor (GPCR) that binds to a specific chemokine, CCL20. The role of CCR6-CCL20 is very well studied in the migration of immune cells, but the non-chemotaxis functions of CCR6 signaling were not known. ...Furthermore, CCR6
CCR6 is a G protein-coupled receptor (GPCR) that binds to a specific chemokine, CCL20. The role of CCR6-CCL20 is very well stu
Modulation of the CCR6-CCL20 Axis: A Potential Therapeutic Target in Inflammation and Cancer.
Ranasinghe R, Eri R. Ranasinghe R, et al. Medicina (Kaunas). 2018 Nov 16;54(5):88. doi: 10.3390/medicina54050088. Medicina (Kaunas). 2018. PMID: 30453514 Free PMC article. Review.
Prototypical functions of the chemokine receptor CCR6 include immune regulation by maneuvering cell chemotaxis and selective delimiting of the pro-inflammatory T(H)17 and regulatory T(reg) subsets during chronic or acute systemic inflammation. Inhibition of CCR6 is …
Prototypical functions of the chemokine receptor CCR6 include immune regulation by maneuvering cell chemotaxis and selective delimiti …
HIV-1 selectively targets gut-homing CCR6+CD4+ T cells via mTOR-dependent mechanisms.
Planas D, Zhang Y, Monteiro P, Goulet JP, Gosselin A, Grandvaux N, Hope TJ, Fassati A, Routy JP, Ancuta P. Planas D, et al. JCI Insight. 2017 Aug 3;2(15):e93230. doi: 10.1172/jci.insight.93230. eCollection 2017 Aug 3. JCI Insight. 2017. PMID: 28768913 Free PMC article.
Although both CCR6+ and CCR6- T cells acquired gut-homing markers upon RA exposure, the modulation of unique sets of genes coincided with preferential HIV-1 replication in RA-treated CCR6+ T cells. ...Finally, CCR6+ versus CCR6- T cells infiltra …
Although both CCR6+ and CCR6- T cells acquired gut-homing markers upon RA exposure, the modulation of unique sets of genes coi …
CCL20, a direct-acting pro-angiogenic chemokine induced by hepatitis C virus (HCV): Potential role in HCV-related liver cancer.
Benkheil M, Van Haele M, Roskams T, Laporte M, Noppen S, Abbasi K, Delang L, Neyts J, Liekens S. Benkheil M, et al. Exp Cell Res. 2018 Nov 15;372(2):168-177. doi: 10.1016/j.yexcr.2018.09.023. Epub 2018 Oct 2. Exp Cell Res. 2018. PMID: 30287142
The CCL20/CCR6 chemokine/receptor axis has previously been shown to contribute to the initiation and progression of hepatocellular carcinoma (HCC) through the recruitment of CCR6-positive leukocytes to the tumor microenvironment. ...To determine the role of the CCL2 …
The CCL20/CCR6 chemokine/receptor axis has previously been shown to contribute to the initiation and progression of hepatocellular ca …
Human CCR6+ Th17 Lymphocytes Are Highly Sensitive to Radiation-Induced Senescence and Are a Potential Target for Prevention of Radiation-Induced Toxicity.
Nguyen HQ, Belkacemi Y, Mann C, Hoffschir F, Kerbrat S, Surenaud M, Zadigue P, de La Taille A, Romeo PH, Le Gouvello S. Nguyen HQ, et al. Int J Radiat Oncol Biol Phys. 2020 Sep 1;108(1):314-325. doi: 10.1016/j.ijrobp.2019.10.045. Epub 2019 Nov 2. Int J Radiat Oncol Biol Phys. 2020. PMID: 31689464
METHODS: This study was performed on peripheral blood mononuclear cells or sorted peripheral memory lymphocytes of CCR6(+) mucosa-homing Th17/CCR6(neg)Th and regulatory T subtypes of healthy volunteers. ...After a 2 Gy IR, both CCR6(+)Th17 and CCR6(neg …
METHODS: This study was performed on peripheral blood mononuclear cells or sorted peripheral memory lymphocytes of CCR6(+) mucosa-hom …
Tumor-derived CCL20 affects B16 melanoma growth in mice.
Martin-Garcia D, Silva-Vilches C, Will R, Enk AH, Lonsdorf AS. Martin-Garcia D, et al. J Dermatol Sci. 2020 Jan;97(1):57-65. doi: 10.1016/j.jdermsci.2019.12.005. Epub 2019 Dec 13. J Dermatol Sci. 2020. PMID: 31883833
Yet, the functional contribution of the CCR6/CCL20 axis for melanoma progression remains controversial. OBJECTIVE: The functional contribution of CCR6-expressing immune cell subsets and local CCL20 in the tumor microenvironment for the immune control of melanoma was …
Yet, the functional contribution of the CCR6/CCL20 axis for melanoma progression remains controversial. OBJECTIVE: The functional con …
CCR6-Positive γδ T Cells Provide Protection Against Intracorneal HSV-1 Infection.
Fitzpatrick S, Lausch R, Barrington RA. Fitzpatrick S, et al. Invest Ophthalmol Vis Sci. 2019 Sep 3;60(12):3952-3962. doi: 10.1167/iovs.19-27810. Invest Ophthalmol Vis Sci. 2019. PMID: 31560369
METHODS: C57Bl/6 (wild-type [WT]), γδ T-cell deficient (TCRδ-/-) and CCR6-deficient (CCR6-/-) mice were infected intracorneally with HSV-1. ...The CCR6+ subset appeared to provide protection against HSV-1 as follows: (1) CCR6-/- mice had more severe co …
METHODS: C57Bl/6 (wild-type [WT]), γδ T-cell deficient (TCRδ-/-) and CCR6-deficient (CCR6-/-) mice were infected intracorneall …
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