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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
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2002 1
2003 3
2004 2
2005 1
2006 1
2007 1
2008 1
2009 2
2010 1
2011 2
2012 3
2013 1
2018 1
2019 1
2020 1
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Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management.
Eaton JE, Talwalkar JA, Lazaridis KN, Gores GJ, Lindor KD. Eaton JE, et al. Gastroenterology. 2013 Sep;145(3):521-36. doi: 10.1053/j.gastro.2013.06.052. Epub 2013 Jul 1. Gastroenterology. 2013. PMID: 23827861 Free PMC article. Review.
Primary sclerosing cholangitis (PSC), first described in the mid-1850s, is a complex liver disease that is heterogeneous in its presentation. ...
Primary sclerosing cholangitis (PSC), first described in the mid-1850s, is a complex liver disease that is heterogeneous in it …
Primary sclerosing cholangitis is associated with abnormalities in CFTR.
Werlin S, Scotet V, Uguen K, Audrezet MP, Cohen M, Yaakov Y, Safadi R, Ilan Y, Konikoff F, Galun E, Mizrahi M, Slae M, Sayag S, Cohen-Cymberknoh M, Wilschanski M, Ferec C. Werlin S, et al. J Cyst Fibros. 2018 Sep;17(5):666-671. doi: 10.1016/j.jcf.2018.04.005. Epub 2018 May 26. J Cyst Fibros. 2018. PMID: 29807875
BACKGROUND: The etiology of primary sclerosing cholangitis (PSC) is unknown. PSC and Cystic Fibrosis related liver disease have common features: chronic inflammation, biliary damage and similar cholangiographic findings. ...CONCLUSIONS: 19% of PSC patients had featu …
BACKGROUND: The etiology of primary sclerosing cholangitis (PSC) is unknown. PSC and Cystic Fibrosis related liver disease hav …
Evolving concepts in primary sclerosing cholangitis.
Krones E, Graziadei I, Trauner M, Fickert P. Krones E, et al. Liver Int. 2012 Mar;32(3):352-69. doi: 10.1111/j.1478-3231.2011.02607.x. Epub 2011 Aug 17. Liver Int. 2012. PMID: 22097926 Review.
Patients suffering from primary sclerosing cholangitis (PSC) show considerable differences regarding clinical manifestations (i.e. large duct versus small-duct PSC, presence or absence of concomitant inflammatory bowel disease), disease progression, risk for maligna …
Patients suffering from primary sclerosing cholangitis (PSC) show considerable differences regarding clinical manifestations ( …
Increased prevalence of CFTR mutations and variants and decreased chloride secretion in primary sclerosing cholangitis.
Sheth S, Shea JC, Bishop MD, Chopra S, Regan MM, Malmberg E, Walker C, Ricci R, Tsui LC, Durie PR, Zielenski J, Freedman SD. Sheth S, et al. Hum Genet. 2003 Aug;113(3):286-92. doi: 10.1007/s00439-003-0963-z. Epub 2003 Jun 3. Hum Genet. 2003. PMID: 12783301
Primary sclerosing cholangitis (PSC) and cystic fibrosis (CF) are both slowly progressive cholestatic liver diseases characterized by fibro-obliterative inflammation of the biliary tract. ...Only one of 19 PSC patients had neither a CFTR mutation nor the 1540 …
Primary sclerosing cholangitis (PSC) and cystic fibrosis (CF) are both slowly progressive cholestatic liver diseases character …
Primary sclerosing cholangitis in childhood is associated with abnormalities in cystic fibrosis-mediated chloride channel function.
Pall H, Zielenski J, Jonas MM, DaSilva DA, Potvin KM, Yuan XW, Huang Q, Freedman SD. Pall H, et al. J Pediatr. 2007 Sep;151(3):255-9. doi: 10.1016/j.jpeds.2007.03.062. Epub 2007 Jul 24. J Pediatr. 2007. PMID: 17719933 Clinical Trial.
OBJECTIVE: To determine whether primary sclerosing cholangitis (PSC) in childhood is associated with abnormalities in cystic fibrosis transmembrane conductance regulator (CFTR). ...Comprehensive CFTR genotyping revealed that 5 of 19 (26.3%) subjects wi …
OBJECTIVE: To determine whether primary sclerosing cholangitis (PSC) in childhood is associated with abnormalities in cystic f …
New insights into autoimmune cholangitis through animal models.
Trauner M, Fickert P, Baghdasaryan A, Claudel T, Halilbasic E, Moustafa T, Wagner M, Zollner G. Trauner M, et al. Dig Dis. 2010;28(1):99-104. doi: 10.1159/000282072. Epub 2010 May 7. Dig Dis. 2010. PMID: 20460897 Review.
Another example for a transporter involved in the pathogenesis of sclerosing cholangitis is the cystic fibrosis transmembrane conductance regulator (CFTR/ABCC7). ...Hydrophobic bile acids, such as lithocholic acid, cause bile duct injury and destructive ch
Another example for a transporter involved in the pathogenesis of sclerosing cholangitis is the cystic fibrosis transmembrane …
Cystic fibrosis transmembrane conductance regulator (CFTR) gene defects in patients with primary sclerosing cholangitis.
Girodon E, Sternberg D, Chazouillères O, Cazeneuve C, Huot D, Calmus Y, Poupon R, Goossens M, Housset C. Girodon E, et al. J Hepatol. 2002 Aug;37(2):192-7. doi: 10.1016/s0168-8278(02)00161-7. J Hepatol. 2002. PMID: 12127423
BACKGROUND/AIMS: Because biliary tract lesions that resemble those of primary sclerosing cholangitis (PSC) may occur in cystic fibrosis (CF), we examined the prevalence and influence of CF transmembrane conductance regulator (CFTR) gene mutations in PSC patie …
BACKGROUND/AIMS: Because biliary tract lesions that resemble those of primary sclerosing cholangitis (PSC) may occur in cystic …
Novel association of HLA-haplotypes with primary sclerosing cholangitis (PSC) in a southern European population.
Neri TM, Cavestro GM, Seghini P, Zanelli PF, Zanetti A, Savi M, Podda M, Zuin M, Colombo M, Floreani A, Rosina F, Bianchi Porro G, Strazzabosco M, Okolicsanyi L. Neri TM, et al. Dig Liver Dis. 2003 Aug;35(8):571-6. doi: 10.1016/s1590-8658(03)00274-3. Dig Liver Dis. 2003. PMID: 14567462
AIMS: In patients with with primary sclerosing cholangitis we investigated the major histocompatibility complex (MHC) genes and mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. METHODS: In 64 PSC patients and 183 normal contro …
AIMS: In patients with with primary sclerosing cholangitis we investigated the major histocompatibility complex (MHC) genes an …
The safety and efficacy of oral docosahexaenoic acid supplementation for the treatment of primary sclerosing cholangitis - a pilot study.
Martin CR, Blanco PG, Keach JC, Petz JL, Zaman MM, Bhaskar KR, Cluette-Brown JE, Gautam S, Sheth S, Afdhal NH, Lindor KD, Freedman SD. Martin CR, et al. Aliment Pharmacol Ther. 2012 Jan;35(2):255-65. doi: 10.1111/j.1365-2036.2011.04926.x. Epub 2011 Nov 30. Aliment Pharmacol Ther. 2012. PMID: 22129201 Free PMC article.
BACKGROUND: Primary sclerosing cholangitis (PSC) is characterised by progressive inflammatory and fibrotic destruction of the biliary ducts. ...Cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction is associated with PSC in both children and …
BACKGROUND: Primary sclerosing cholangitis (PSC) is characterised by progressive inflammatory and fibrotic destruction of the …
CFTR dysfunction predisposes to fibrotic liver disease in a murine model.
Martin CR, Zaman MM, Ketwaroo GA, Bhutta AQ, Coronel E, Popov Y, Schuppan D, Freedman SD. Martin CR, et al. Am J Physiol Gastrointest Liver Physiol. 2012 Aug 15;303(4):G474-81. doi: 10.1152/ajpgi.00055.2012. Epub 2012 Jun 7. Am J Physiol Gastrointest Liver Physiol. 2012. PMID: 22679000 Free PMC article.
Cystic fibrosis liver disease (CFLD) is a rapidly progressive biliary fibrosis, resembling primary sclerosing cholangitis that develops in 5-10% of patients with cystic fibrosis. ...Although primary sclerosing cholangitis is linked to both ulcerative c …
Cystic fibrosis liver disease (CFLD) is a rapidly progressive biliary fibrosis, resembling primary sclerosing cholangitis that …
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