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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
1999 1
2000 2
2002 3
2003 1
2004 4
2005 12
2006 19
2007 19
2008 12
2009 6
2010 7
2011 5
2012 3
2013 7
2014 5
2015 4
2016 9
2017 3
2018 7
2019 7
2020 5
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126 results
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β-TrCP-mediated ubiquitination and degradation of Dlg5 regulates hepatocellular carcinoma cell proliferation.
Wang D, Zhang Q, Li F, Wang C, Yang C, Yu H. Wang D, et al. Cancer Cell Int. 2019 Nov 15;19:298. doi: 10.1186/s12935-019-1029-1. eCollection 2019. Cancer Cell Int. 2019. PMID: 31787846 Free PMC article.
Dlg5 was down-regulated in hepatocellular carcinoma (HCC) and lower Dlg5 expression was associated with poor survival of HCC patients. ...We further demonstrated a crucial role of Ser730 in the non-canonical phosphodegron of Dlg5 in governing β-TrCP-mediated
Dlg5 was down-regulated in hepatocellular carcinoma (HCC) and lower Dlg5 expression was associated with poor survival of HCC p
Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.
Liu J, Li J, Li P, Wang Y, Liang Z, Jiang Y, Li J, Feng C, Wang R, Chen H, Zhou C, Zhang J, Yang J, Liu P. Liu J, et al. Sci Rep. 2017 Feb 7;7:42125. doi: 10.1038/srep42125. Sci Rep. 2017. PMID: 28169360 Free PMC article.
Discs Large Homolog 5 (DLG5) plays an important role in the maintenance of epithelial cell polarity. Recent research showed that DLG5 is decreased in Yes-associated protein (YAP)-overexpressing cells. However, the exact relationship between DLG5 and YAP is no …
Discs Large Homolog 5 (DLG5) plays an important role in the maintenance of epithelial cell polarity. Recent research showed that D
DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.
Kwan J, Sczaniecka A, Heidary Arash E, Nguyen L, Chen CC, Ratkovic S, Klezovitch O, Attisano L, McNeill H, Emili A, Vasioukhin V. Kwan J, et al. Genes Dev. 2016 Dec 15;30(24):2696-2709. doi: 10.1101/gad.284539.116. Genes Dev. 2016. PMID: 28087714 Free PMC article.
Consistent with this finding, Hippo signaling is markedly hyperactive in mammalian Dlg5(-/-) tissues and cells in vivo and ex vivo and in Drosophila upon dlg5 knockdown. Conditional deletion of Mst1/2 fully rescued the phenotypes of brain-specific Dlg5 knocko …
Consistent with this finding, Hippo signaling is markedly hyperactive in mammalian Dlg5(-/-) tissues and cells in vivo and ex vivo an …
Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase.
Muñoz IM, Morgan ME, Peltier J, Weiland F, Gregorczyk M, Brown FC, Macartney T, Toth R, Trost M, Rouse J. Muñoz IM, et al. EMBO J. 2018 Dec 14;37(24):e99559. doi: 10.15252/embj.201899559. Epub 2018 Sep 28. EMBO J. 2018. PMID: 30266825 Free PMC article.
Here, we describe a quantitative phosphoproteomic screening which identified MAP1S, CEP131 and DLG5-regulators of microtubule and centrosome function-as cellular substrates of CDKL5. ...The phospho-acceptor serine residues in MAP1S, CEP131 and DLG5 lie in the motif …
Here, we describe a quantitative phosphoproteomic screening which identified MAP1S, CEP131 and DLG5-regulators of microtubule and cen …
The polarity protein Dlg5 regulates collective cell migration during Drosophila oogenesis.
Luo J, Zhou P, Guo X, Wang D, Chen J. Luo J, et al. PLoS One. 2019 Dec 19;14(12):e0226061. doi: 10.1371/journal.pone.0226061. eCollection 2019. PLoS One. 2019. PMID: 31856229 Free PMC article.
Two genes were uncovered, including dlg5 (discs large 5) and CG31689. Further analysis showed that Dlg5 regulates the apical-basal polarity and cluster integrity in border cell clusters. ...We found that the distribution of Dlg5 in border cell clusters is reg …
Two genes were uncovered, including dlg5 (discs large 5) and CG31689. Further analysis showed that Dlg5 regulates the apical-b …
Discs large homolog 5 decreases formation and function of invadopodia in human hepatocellular carcinoma via Girdin and Tks5.
Ke Y, Bao T, Zhou Q, Wang Y, Ge J, Fu B, Wu X, Tang H, Shi Z, Lei X, Zhang C, Tan Y, Chen H, Guo Z, Wang L. Ke Y, et al. Int J Cancer. 2017 Jul 15;141(2):364-376. doi: 10.1002/ijc.30730. Epub 2017 May 9. Int J Cancer. 2017. PMID: 28390157 Free article.
Furthermore, Dlg5 interacted with Girdin and interfered with the interaction of Girdin and Tks5. Dlg5 silencing promoted Girdin and Tks5 phosphorylation, which was abrogated by Girdin silencing and rescued by inducing shRNA-resistant Girdin expression. ...Conceivabl …
Furthermore, Dlg5 interacted with Girdin and interfered with the interaction of Girdin and Tks5. Dlg5 silencing promoted Girdi …
Novel significant stage-specific differentially expressed genes in hepatocellular carcinoma.
Sarathi A, Palaniappan A. Sarathi A, et al. BMC Cancer. 2019 Jul 5;19(1):663. doi: 10.1186/s12885-019-5838-3. BMC Cancer. 2019. PMID: 31277598 Free PMC article.
RESULTS: Our analysis yielded two stage-I specific genes (CA9, WNT7B), two stage-II specific genes (APOBEC3B, FAM186A), ten stage-III specific genes including DLG5, PARI, NCAPG2, GNMT and XRCC2, and 35 stage-IV specific genes including GABRD, PGAM2, PECAM1 and CXCR2P1. Ove …
RESULTS: Our analysis yielded two stage-I specific genes (CA9, WNT7B), two stage-II specific genes (APOBEC3B, FAM186A), ten stage-III specif …
Methylation-mediated silencing of Dlg5 facilitates bladder cancer metastasis.
Zhou Z, Guo Y, Liu Y, Zhang F, Wang Y, Shen B, Qin Y, Qiu J. Zhou Z, et al. Exp Cell Res. 2015 Feb 15;331(2):399-407. doi: 10.1016/j.yexcr.2014.11.015. Epub 2014 Dec 3. Exp Cell Res. 2015. PMID: 25478998
The expression of Dlg5 is decreased in most bladder cancer tissues compared with adjacent normal tissues, and Dlg5 expression is further downregulated in patients with muscle-invasive tumors. ...Hypermethylation of Dlg5 in bladder tumors is tightly correlated …
The expression of Dlg5 is decreased in most bladder cancer tissues compared with adjacent normal tissues, and Dlg5 expression …
Role of Dlg5/lp-dlg, a membrane-associated guanylate kinase family protein, in epithelial-mesenchymal transition in LLc-PK1 renal epithelial cells.
Sezaki T, Inada K, Sogabe T, Kakuda K, Tomiyama L, Matsuno Y, Ichikawa T, Matsuo M, Ueda K, Kioka N. Sezaki T, et al. PLoS One. 2012;7(4):e35519. doi: 10.1371/journal.pone.0035519. Epub 2012 Apr 23. PLoS One. 2012. PMID: 22539977 Free PMC article.
Dlg5 has been described as a susceptibility gene for Crohn's disease; however, the physiological function of Dlg5 is unknown. ...In addition, activation of JNK and p38, which are stimulated by TGF-β, was enhanced by Dlg5 depletion. Furthermore, inhibition of
Dlg5 has been described as a susceptibility gene for Crohn's disease; however, the physiological function of Dlg5 is unknown.
DLG5 in cell polarity maintenance and cancer development.
Liu J, Li J, Ren Y, Liu P. Liu J, et al. Int J Biol Sci. 2014 May 3;10(5):543-9. doi: 10.7150/ijbs.8888. eCollection 2014. Int J Biol Sci. 2014. PMID: 24910533 Free PMC article. Review.
As the other family members, DLG5 contains the multi-PDZ, SH3 and GUK domains. DLG5 has evolved in the same manner as DLG1 and ZO1, two well-studied MAGUKs proteins. ...Since the roles of DLG5 in inflammatory bowel disease (IBD) and Crohn's disease (CD) have …
As the other family members, DLG5 contains the multi-PDZ, SH3 and GUK domains. DLG5 has evolved in the same manner as DLG1 and …
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