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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1978 2
1982 1
1983 2
1986 1
1987 1
1988 2
1989 2
1990 1
1991 5
1992 2
1993 3
1994 18
1995 42
1996 23
1997 20
1998 19
1999 19
2000 14
2001 16
2002 19
2003 20
2004 23
2005 14
2006 22
2007 27
2008 15
2009 24
2010 20
2011 24
2012 14
2013 10
2014 13
2015 17
2016 12
2017 15
2018 17
2019 19
2020 11
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492 results
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Page 1
Host DNases prevent vascular occlusion by neutrophil extracellular traps.
Jiménez-Alcázar M, Rangaswamy C, Panda R, Bitterling J, Simsek YJ, Long AT, Bilyy R, Krenn V, Renné C, Renné T, Kluge S, Panzer U, Mizuta R, Mannherz HG, Kitamura D, Herrmann M, Napirei M, Fuchs TA. Jiménez-Alcázar M, et al. Science. 2017 Dec 1;358(6367):1202-1206. doi: 10.1126/science.aam8897. Science. 2017. PMID: 29191910
We investigated which host factors control NETs in vivo and found that two deoxyribonucleases (DNases), DNase1 and DNase1-like 3, degraded NETs in circulation during sterile neutrophilia and septicemia. ...DNase1 and DNase1-like 3 are independently exp …
We investigated which host factors control NETs in vivo and found that two deoxyribonucleases (DNases), DNase1 and DNase1-like …
Neutrophil extracellular traps promote differentiation and function of fibroblasts.
Chrysanthopoulou A, Mitroulis I, Apostolidou E, Arelaki S, Mikroulis D, Konstantinidis T, Sivridis E, Koffa M, Giatromanolaki A, Boumpas DT, Ritis K, Kambas K. Chrysanthopoulou A, et al. J Pathol. 2014 Jul;233(3):294-307. doi: 10.1002/path.4359. Epub 2014 May 19. J Pathol. 2014. PMID: 24740698
These fibrotic effects were significantly decreased after degradation of NETs with DNase1, heparin or myeloperoxidase inhibitor, indicating the key role of NET-derived components in LF differentiation and function. ...
These fibrotic effects were significantly decreased after degradation of NETs with DNase1, heparin or myeloperoxidase inhibitor, indi …
Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury.
Caudrillier A, Kessenbrock K, Gilliss BM, Nguyen JX, Marques MB, Monestier M, Toy P, Werb Z, Looney MR. Caudrillier A, et al. J Clin Invest. 2012 Jul;122(7):2661-71. doi: 10.1172/JCI61303. Epub 2012 Jun 11. J Clin Invest. 2012. PMID: 22684106 Free PMC article.
We then directly targeted NET components with a histone blocking antibody and DNase1, both of which protected mice from TRALI. ...
We then directly targeted NET components with a histone blocking antibody and DNase1, both of which protected mice from TRALI. ...
Dendrobium nobile Lindley and its bibenzyl component moscatilin are able to protect retinal cells from ischemia/hypoxia by dowregulating placental growth factor and upregulating Norrie disease protein.
Chao WH, Lai MY, Pan HT, Shiu HW, Chen MM, Chao HM. Chao WH, et al. BMC Complement Altern Med. 2018 Jun 22;18(1):193. doi: 10.1186/s12906-018-2256-z. BMC Complement Altern Med. 2018. PMID: 29933759 Free PMC article.
These ischemic effects were significantly altered when 1.0 g/Kg/day DNL (DNL1.0 + I/R or I/R+ DNL1.0) was applied before and/or after ischemia, but not vehicle (Vehicle+I/R). Of novelty and significance, the DNL1.0 action mechanism appears to be similar to th …
These ischemic effects were significantly altered when 1.0 g/Kg/day DNL (DNL1.0 + I/R or I/R+ DNL1.0) was applied before and/o …
Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis.
Hakkim A, Fürnrohr BG, Amann K, Laube B, Abed UA, Brinkmann V, Herrmann M, Voll RE, Zychlinsky A. Hakkim A, et al. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9813-8. doi: 10.1073/pnas.0909927107. Epub 2010 May 3. Proc Natl Acad Sci U S A. 2010. PMID: 20439745 Free PMC article.
Here we show that serum endonuclease DNase1 is essential for disassembly of NETs. Interestingly, a subset of SLE patients' sera degraded NETs poorly. Two mechanisms caused this impaired NET degradation: (i) the presence of DNase1 inhibitors or (ii) anti-NET antibodi …
Here we show that serum endonuclease DNase1 is essential for disassembly of NETs. Interestingly, a subset of SLE patients' sera degra …
Simplified Human Neutrophil Extracellular Traps (NETs) Isolation and Handling.
Najmeh S, Cools-Lartigue J, Giannias B, Spicer J, Ferri LE. Najmeh S, et al. J Vis Exp. 2015 Apr 16;(98):52687. doi: 10.3791/52687. J Vis Exp. 2015. PMID: 25938591 Free PMC article.
In some wells, 1000U DNAse1 is added 10 min before counting to degrade NETs....
In some wells, 1000U DNAse1 is added 10 min before counting to degrade NETs....
Dnase1-deficient mice spontaneously develop a systemic lupus erythematosus-like disease.
Kenny EF, Raupach B, Abu Abed U, Brinkmann V, Zychlinsky A. Kenny EF, et al. Eur J Immunol. 2019 Apr;49(4):590-599. doi: 10.1002/eji.201847875. Epub 2019 Feb 21. Eur J Immunol. 2019. PMID: 30758851 Free article.
The endonuclease deoxyribonuclease 1 (DNase1) is abundant in blood and a subset of SLE patients have mutations in DNASE1. Furthermore, a report showed that Dnase1-deficient mice develop an SLE-like disease, but these mice also carry a deletion of the gene adj …
The endonuclease deoxyribonuclease 1 (DNase1) is abundant in blood and a subset of SLE patients have mutations in DNASE1. Furt …
Hypoxia-induced human deoxyribonuclease I is a cellular restriction factor of hepatitis B virus.
Hallez C, Li X, Suspène R, Thiers V, Bouzidi MS, M Dorobantu C, Lucansky V, Wain-Hobson S, Gaudin R, Vartanian JP. Hallez C, et al. Nat Microbiol. 2019 Jul;4(7):1196-1207. doi: 10.1038/s41564-019-0405-x. Epub 2019 Apr 1. Nat Microbiol. 2019. PMID: 30936483
DNASE1 is overexpressed and encapsidated in HBV particles in vitro in hypoxic environments and in vivo in cirrhotic patient livers as well as in the serum of infected patients. ...Indeed, transfection with HIF-1α and HIF-1β expression constructs upregulated DNASE1.
DNASE1 is overexpressed and encapsidated in HBV particles in vitro in hypoxic environments and in vivo in cirrhotic patient livers as
DNase1: No Association with Crohn's Disease in a New Zealand Population.
Morgan AR, Lam WJ, Han DY, Fraser AG, Ferguson LR. Morgan AR, et al. ISRN Gastroenterol. 2012;2012:826323. doi: 10.5402/2012/826323. Epub 2012 Jun 4. ISRN Gastroenterol. 2012. PMID: 22701800 Free PMC article.
DNase1 has been implicated in a number of immune disorders and is an excellent candidate gene for Crohn's disease (CD). We investigated whether DNase1 SNPs rs1053874 and rs8176938 were associated with CD in a well-characterized New Zealand dataset consisting of 447
DNase1 has been implicated in a number of immune disorders and is an excellent candidate gene for Crohn's disease (CD). We investigat
Dnase1l3 deletion causes aberrations in length and end-motif frequencies in plasma DNA.
Serpas L, Chan RWY, Jiang P, Ni M, Sun K, Rashidfarrokhi A, Soni C, Sisirak V, Lee WS, Cheng SH, Peng W, Chan KCA, Chiu RWK, Reizis B, Lo YMD. Serpas L, et al. Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):641-649. doi: 10.1073/pnas.1815031116. Epub 2018 Dec 28. Proc Natl Acad Sci U S A. 2019. PMID: 30593563 Free PMC article.
DNASE1L3 is a secreted DNASE1-like nuclease capable of digesting DNA in chromatin, and its absence causes anti-DNA responses and autoimmunity in humans and mice. ...
DNASE1L3 is a secreted DNASE1-like nuclease capable of digesting DNA in chromatin, and its absence causes anti-DNA responses and auto …
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