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2019 5
2020 1
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Bile acid-induced apoptosis and bile acid synthesis are reduced by over-expression of Augmenter of Liver Regeneration (ALR) in a STAT3-dependent mechanism.
Ibrahim S, Dayoub R, Krautbauer S, Liebisch G, Wege AK, Melter M, Weiss TS. Ibrahim S, et al. Exp Cell Res. 2019 Jan 1;374(1):189-197. doi: 10.1016/j.yexcr.2018.11.023. Epub 2018 Nov 28. Exp Cell Res. 2019. PMID: 30500391
Bile acids induce apoptosis, ER stress and mitochondrial membrane instability. In this study we aimed to investigate the role of cytosolic short form of ALR (Augmenter of Liver Regeneration) in the synthesis of bile acids and bile acid-induced apoptosis. ...W
Bile acids induce apoptosis, ER stress and mitochondrial membrane instability. In this study we aimed to investigate the role of cyto
The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis.
Ploton M, Mazuy C, Gheeraert C, Dubois V, Berthier A, Dubois-Chevalier J, Maréchal X, Bantubungi K, Diemer H, Cianférani S, Strub JM, Helleboid-Chapman A, Eeckhoute J, Staels B, Lefebvre P. Ploton M, et al. J Hepatol. 2018 Nov;69(5):1099-1109. doi: 10.1016/j.jhep.2018.06.022. Epub 2018 Jul 5. J Hepatol. 2018. PMID: 29981427 Free article.
BACKGROUND & AIMS: Embedded into a complex signaling network that coordinates glucose uptake, usage and production, the nuclear bile acid receptor FXR is expressed in several glucose-processing organs including the liver. ...LAY SUMMARY: Activation of the nuclear bi
BACKGROUND & AIMS: Embedded into a complex signaling network that coordinates glucose uptake, usage and production, the nuclear bile
Loss of FoxA2 accelerates neoplastic changes in the intrahepatic bile duct partly via the MAPK signaling pathway.
Shen J, Zhou Y, Zhang X, Peng W, Peng C, Zhou Q, Li C, Wen T, Shi Y. Shen J, et al. Aging (Albany NY). 2019 Nov 5;11(21):9280-9294. doi: 10.18632/aging.102332. Epub 2019 Nov 5. Aging (Albany NY). 2019. PMID: 31689237 Free PMC article.
FOXA2 is an archetypal transcription factor involved in cholangiocyte proliferation. RESULTS: FOXA2 expression was negatively correlated with tumor stage (p = 0.024). ...CONCLUSION: Low FOXA2 expression negatively affected the prognosis of patients with ICC.
FOXA2 is an archetypal transcription factor involved in cholangiocyte proliferation. RESULTS: FOXA2 expression was negatively
Foxa1 and Foxa2 regulate bile duct development in mice.
Li Z, White P, Tuteja G, Rubins N, Sackett S, Kaestner KH. Li Z, et al. J Clin Invest. 2009 Jun;119(6):1537-45. doi: 10.1172/JCI38201. Epub 2009 May 11. J Clin Invest. 2009. PMID: 19436110 Free PMC article.
The forkhead box proteins A1 and A2 (Foxa1 and Foxa2) are transcription factors with critical roles in establishing the developmental competence of the foregut endoderm and in initiating liver specification. ...Our data suggest that Foxa1/2 function as terminators of bi
The forkhead box proteins A1 and A2 (Foxa1 and Foxa2) are transcription factors with critical roles in establishing the developmental …
Foxa1 and Foxa2 regulate bile duct development in mice.
Strazzabosco M. Strazzabosco M. J Hepatol. 2010 May;52(5):765-7. doi: 10.1016/j.jhep.2009.12.022. Epub 2010 Feb 18. J Hepatol. 2010. PMID: 20347503 Free PMC article.
The forkhead box proteins A1 and A2 (Foxa1 and Foxa2) are transcription factors with critical roles in establishing the developmental competence of the foregut endoderm and in initiating liver specification. ...Our data suggest that Foxa1/2 function as terminators of bi
The forkhead box proteins A1 and A2 (Foxa1 and Foxa2) are transcription factors with critical roles in establishing the developmental …
Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress.
Bochkis IM, Rubins NE, White P, Furth EE, Friedman JR, Kaestner KH. Bochkis IM, et al. Nat Med. 2008 Aug;14(8):828-36. doi: 10.1038/nm.1853. Epub 2008 Jul 27. Nat Med. 2008. PMID: 18660816 Free PMC article.
We show by global location analysis ('ChIP-on-chip') and cell type-specific gene ablation that the winged helix transcription factor Foxa2 is required for normal bile acid homeostasis. ...Foxa2-deficient mice are strikingly sensitive to a diet containing chol …
We show by global location analysis ('ChIP-on-chip') and cell type-specific gene ablation that the winged helix transcription factor Foxa
Establishment and Characterization of Two Novel Cholangiocarcinoma Cell Lines.
Zhang Y, Luo J, Dong X, Yang F, Zhang M, Zhao J, Wang Q, Zhou F, Sun J, Yang X. Zhang Y, et al. Ann Surg Oncol. 2019 Nov;26(12):4134-4147. doi: 10.1245/s10434-019-07649-5. Epub 2019 Jul 29. Ann Surg Oncol. 2019. PMID: 31359275 Free PMC article.
An immunophenotype analysis showed that ZJU-0826 is positive for CD44, CD29, Pdx1, CD236, FoxA1, FoxA2, and Nanog, and ZJU-1125 positive for CD44, CD29, CD133, Pdx1, FoxA1, FoxA2, and Nanog. ...
An immunophenotype analysis showed that ZJU-0826 is positive for CD44, CD29, Pdx1, CD236, FoxA1, FoxA2, and Nanog, and ZJU-1125 posit …
Reduced Immunohistochemical Expression of Hnf1β and FoxA2 in Liver Tissue Can Discriminate Between Biliary Atresia and Other Causes of Neonatal Cholestasis.
Shaalan UF, Ibrahim NL, Ehsan NA, Sultan MM, Naser GM, Abd El-Fatah MO. Shaalan UF, et al. Appl Immunohistochem Mol Morphol. 2019 Apr;27(4):e32-e38. doi: 10.1097/PAI.0000000000000638. Appl Immunohistochem Mol Morphol. 2019. PMID: 29406331 Clinical Trial.
Moreover, Hnf1β was significantly correlated with FoxA2 immunoexpression, stage of fibrosis, bile ductular proliferation, and bile plugs in bile ductules. ...Hnf1β and FoxA2 immunoexpression could differentiate between BA from other cause of NC. …
Moreover, Hnf1β was significantly correlated with FoxA2 immunoexpression, stage of fibrosis, bile ductular proliferation, and …
Triple Staining Including FOXA2 Identifies Stem Cell Lineages Undergoing Hepatic and Biliary Differentiation in Cirrhotic Human Liver.
Rogler CE, Bebawee R, Matarlo J, Locker J, Pattamanuch N, Gupta S, Rogler LE. Rogler CE, et al. J Histochem Cytochem. 2017 Jan;65(1):33-46. doi: 10.1369/0022155416675153. Epub 2016 Nov 24. J Histochem Cytochem. 2017. PMID: 27879410 Free PMC article.
We have used combined immunohistochemical staining for a marker of hepatic commitment and specification (FOXA2 [Forkhead box A2]), hepatocyte maturation (Albumin and HepPar1), and features of bile ducts (CK19 [cytokeratin 19]) to identify lineages of stem cells diff …
We have used combined immunohistochemical staining for a marker of hepatic commitment and specification (FOXA2 [Forkhead box A2]), he …
Transient c-Src Suppression During Endodermal Commitment of Human Induced Pluripotent Stem Cells Results in Abnormal Profibrotic Cholangiocyte-Like Cells.
Chaudhari P, Tian L, Kim A, Zhu Q, Anders R, Schwarz KB, Sharkis S, Ye Z, Jang YY. Chaudhari P, et al. Stem Cells. 2019 Mar;37(3):306-317. doi: 10.1002/stem.2950. Epub 2018 Dec 17. Stem Cells. 2019. PMID: 30471152 Free PMC article.
Transient inhibition of c-Src during endodermal induction of human iPSCs reduced endodermal commitment and expression of endodermal markers, including SOX17 and FOXA2, in a dose-dependent manner. ...Further analysis of these cells revealed colocalized expression of collage …
Transient inhibition of c-Src during endodermal induction of human iPSCs reduced endodermal commitment and expression of endodermal markers, …
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