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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
2001 10
2002 3
2003 23
2004 87
2005 234
2006 489
2007 790
2008 1057
2009 1247
2010 1366
2011 1526
2012 1562
2013 1555
2014 1512
2015 1520
2016 1447
2017 1491
2018 1406
2019 1398
2020 1494
2021 139
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17,989 results
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Page 1
FOXP3 and its role in the immune system.
Kim CH. Kim CH. Adv Exp Med Biol. 2009;665:17-29. doi: 10.1007/978-1-4419-1599-3_2. Adv Exp Med Biol. 2009. PMID: 20429413 Review.
FOXP3+ T-cells are made in the thymus and periphery. The FOXP3+ T-cells made in the thymus migrate to secondary lymphoid tissues and suppress antigen priming of lymphocytes. Antigen priming of naive FOXP3 T-cdlls and naive FOXP3 T-cells leads to genera
FOXP3+ T-cells are made in the thymus and periphery. The FOXP3+ T-cells made in the thymus migrate to secondary lymphoid tissu
CRISPRa-mediated FOXP3 gene upregulation in mammalian cells.
Forstnerič V, Oven I, Ogorevc J, Lainšček D, Praznik A, Lebar T, Jerala R, Horvat S. Forstnerič V, et al. Cell Biosci. 2019 Nov 21;9:93. doi: 10.1186/s13578-019-0357-0. eCollection 2019. Cell Biosci. 2019. PMID: 31832140 Free PMC article.
Simultaneous targeting of FOXP3 and EOS, a transcription factor known to act in concert with FOXP3 in initiating a Treg phenotype, resulted in upregulation of FOXP3 downstream genes CD25 and TNFR2. When compared to ectopic expression of FOXP3 via plasm …
Simultaneous targeting of FOXP3 and EOS, a transcription factor known to act in concert with FOXP3 in initiating a Treg phenot …
Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis.
Shang B, Liu Y, Jiang SJ, Liu Y. Shang B, et al. Sci Rep. 2015 Oct 14;5:15179. doi: 10.1038/srep15179. Sci Rep. 2015. PMID: 26462617 Free PMC article. Review.
The prognostic value of FoxP3(+) regulatory T cells (Tregs) in cancer remains controversial. ...High FoxP3(+) Tregs infiltration was significantly associated with shorter OS in the majority of solid tumors studied, including cervical, renal, melanomas, and breast ca …
The prognostic value of FoxP3(+) regulatory T cells (Tregs) in cancer remains controversial. ...High FoxP3(+) Tregs infiltrati …
Control of regulatory T-cell differentiation and function by T-cell receptor signalling and Foxp3 transcription factor complexes.
Ono M. Ono M. Immunology. 2020 May;160(1):24-37. doi: 10.1111/imm.13178. Epub 2020 Mar 9. Immunology. 2020. PMID: 32022254 Review.
Studies in the past decades identified numerous Foxp3-interacting protein partners. However, it is still not clear how Foxp3 produces the Treg-type transcriptomic landscape through cooperating with its partners. ...Next, I discuss the following key topics, proposing …
Studies in the past decades identified numerous Foxp3-interacting protein partners. However, it is still not clear how Foxp3 p …
DNA methylation controls Foxp3 gene expression.
Polansky JK, Kretschmer K, Freyer J, Floess S, Garbe A, Baron U, Olek S, Hamann A, von Boehmer H, Huehn J. Polansky JK, et al. Eur J Immunol. 2008 Jun;38(6):1654-63. doi: 10.1002/eji.200838105. Eur J Immunol. 2008. PMID: 18493985 Free article.
Recently, we have shown that naturally occurring, but not in vitro TGF-beta-induced Foxp3(+) Treg display stable Foxp3 expression that was associated with selective demethylation of an evolutionarily conserved element within the Foxp3 locus named TSDR (Treg-s …
Recently, we have shown that naturally occurring, but not in vitro TGF-beta-induced Foxp3(+) Treg display stable Foxp3 express …
Epigenetic control of the foxp3 locus in regulatory T cells.
Floess S, Freyer J, Siewert C, Baron U, Olek S, Polansky J, Schlawe K, Chang HD, Bopp T, Schmitt E, Klein-Hessling S, Serfling E, Hamann A, Huehn J. Floess S, et al. PLoS Biol. 2007 Feb;5(2):e38. doi: 10.1371/journal.pbio.0050038. PLoS Biol. 2007. PMID: 17298177 Free PMC article.
Partial DNA demethylation is already found within developing Foxp3(+) thymocytes; however, Tregs induced by TGF-beta in vitro display only incomplete demethylation despite high Foxp3 expression. In contrast to natural Tregs, these TGF-beta-induced Foxp3(+) Tr …
Partial DNA demethylation is already found within developing Foxp3(+) thymocytes; however, Tregs induced by TGF-beta in vitro display …
Recovery of CD226-TIGIT(+)FoxP3(+) and CD226-TIGIT-FoxP3(+) regulatory T cells contributes to clinical remission from active stage in ulcerative colitis patients.
Long Y, Wang C, Xia C, Li X, Fan C, Zhao X, Liu C. Long Y, et al. Immunol Lett. 2020 Feb;218:30-39. doi: 10.1016/j.imlet.2019.12.007. Epub 2019 Dec 26. Immunol Lett. 2020. PMID: 31883787
RESULTS: In active UC, levels of FoxP3(+)Tregs and CD226(-)FoxP3(+)Tregs regardless of TIGIT expression were significantly decreased while percentages of CD226(+)TIGIT(-)FoxP3(+)Tregs and CD226(+)TIGIT(+)FoxP3(+)Tregs were obviously increased. ...Furth …
RESULTS: In active UC, levels of FoxP3(+)Tregs and CD226(-)FoxP3(+)Tregs regardless of TIGIT expression were significantly dec …
Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells.
Zheng Y, Josefowicz SZ, Kas A, Chu TT, Gavin MA, Rudensky AY. Zheng Y, et al. Nature. 2007 Feb 22;445(7130):936-40. doi: 10.1038/nature05563. Epub 2007 Jan 21. Nature. 2007. PMID: 17237761
We find that a large number of Foxp3-bound genes are up- or downregulated in Foxp3+ T cells, suggesting that Foxp3 acts as both a transcriptional activator and repressor. Foxp3-mediated regulation unique to the thymus affects, among others, genes encod …
We find that a large number of Foxp3-bound genes are up- or downregulated in Foxp3+ T cells, suggesting that Foxp3 acts …
Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.
Miyao T, Floess S, Setoguchi R, Luche H, Fehling HJ, Waldmann H, Huehn J, Hori S. Miyao T, et al. Immunity. 2012 Feb 24;36(2):262-75. doi: 10.1016/j.immuni.2011.12.012. Epub 2012 Feb 9. Immunity. 2012. PMID: 22326580 Free article.
By genetic fate mapping or adoptive transfers, we have identified a minor population of nonregulatory Foxp3(+) T cells exhibiting promiscuous and transient Foxp3 expression, which gave rise to Foxp3(-) ("exFoxp3") Th cells and selectively accumulated in infla …
By genetic fate mapping or adoptive transfers, we have identified a minor population of nonregulatory Foxp3(+) T cells exhibiting pro …
Down-regulation of Tet2 is associated with Foxp3 TSDR hypermethylation in regulatory T cell of allergic rhinitis.
Tan L, Qiu T, Xiang R, Cao C, Deng Y, Tao Z, Xu Y. Tan L, et al. Life Sci. 2020 Jan 15;241:117101. doi: 10.1016/j.lfs.2019.117101. Epub 2019 Nov 25. Life Sci. 2020. PMID: 31778687
Hypermethylation of Foxp3 TSDR and decline of TET2 binding to Foxp3 TSDR, but not promoter, were noted in Treg cells of OVA-exposed mice. Significant negative correlations between Tet2 expression and Foxp3 TSDR methylation, Foxp3 TSDR methylation and …
Hypermethylation of Foxp3 TSDR and decline of TET2 binding to Foxp3 TSDR, but not promoter, were noted in Treg cells of OVA-ex …
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