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HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation.
Fosby B, Næss S, Hov JR, Traherne J, Boberg KM, Trowsdale J, Foss A, Line PD, Franke A, Melum E, Scott H, Karlsen TH. Fosby B, et al. World J Gastroenterol. 2014 Apr 14;20(14):3986-4000. doi: 10.3748/wjg.v20.i14.3986. World J Gastroenterol. 2014. PMID: 24744588 Free PMC article.
The same was observed for the HLA-C*07 allele with AR in 57%, 27% and 18% in recipients being homozygous, heterozygous and lacking HLA-C*07 respectively (P = 0.003). ...CONCLUSION: We found significant associations between the PSC-associated HLA
The same was observed for the HLA-C*07 allele with AR in 57%, 27% and 18% in recipients being homozygous, heterozygous and lac …
Genetic associations in Italian primary sclerosing cholangitis: heterogeneity across Europe defines a critical role for HLA-C.
Hov JR, Lleo A, Selmi C, Woldseth B, Fabris L, Strazzabosco M, Karlsen TH, Invernizzi P. Hov JR, et al. J Hepatol. 2010 May;52(5):712-7. doi: 10.1016/j.jhep.2009.11.029. Epub 2010 Mar 4. J Hepatol. 2010. PMID: 20347497
BACKGROUND & AIMS: The HLA complex on chromosome 6p21 is firmly established as a risk locus for primary sclerosing cholangitis (PSC). ...METHODS: Seventy-eight North-Italian PSC patients and 79 controls were included. We performed sequencing-based …
BACKGROUND & AIMS: The HLA complex on chromosome 6p21 is firmly established as a risk locus for primary sclerosing
Particular genetic variants of ligands for natural killer cell receptors may contribute to the HLA associated risk of primary sclerosing cholangitis.
Karlsen TH, Boberg KM, Olsson M, Sun JY, Senitzer D, Bergquist A, Schrumpf E, Thorsby E, Lie BA. Karlsen TH, et al. J Hepatol. 2007 May;46(5):899-906. doi: 10.1016/j.jhep.2007.01.032. Epub 2007 Feb 27. J Hepatol. 2007. PMID: 17383044
We aimed to clarify to what extent such combinations influence susceptibility to primary sclerosing cholangitis (PSC). METHODS: Three hundred and sixty-five Scandinavian PSC patients and 368 healthy controls were genotyped for the presence or absence of genes …
We aimed to clarify to what extent such combinations influence susceptibility to primary sclerosing cholangitis (PSC). …
Human leukocyte antigen-C genes and susceptibility to primary sclerosing cholangitis.
Moloney MM, Thomson LJ, Strettell MJ, Williams R, Donaldson PT. Moloney MM, et al. Hepatology. 1998 Sep;28(3):660-2. doi: 10.1002/hep.510280309. Hepatology. 1998. PMID: 9731555
The aim of this study was to characterize the distribution of HLA C alleles in a large group of patients with primary sclerosing cholangitis by using a recently developed polymerase chain reaction-based genotyping technique. ...These findings in …
The aim of this study was to characterize the distribution of HLA C alleles in a large group of patients with primary
Small duct primary sclerosing cholangitis without inflammatory bowel disease is genetically different from large duct disease.
Naess S, Björnsson E, Anmarkrud JA, Al Mamari S, Juran BD, Lazaridis KN, Chapman R, Bergquist A, Melum E, Marsh SG, Schrumpf E, Lie BA, Boberg KM, Karlsen TH, Hov JR. Naess S, et al. Liver Int. 2014 Nov;34(10):1488-95. doi: 10.1111/liv.12492. Epub 2014 Mar 7. Liver Int. 2014. PMID: 24517468 Free PMC article.
BACKGROUND & AIMS: Small duct primary sclerosing cholangitis (PSC) is phenotypically a mild version of large duct PSC, but it is unknown whether these phenotypes share aetiology. ...METHODS: Four classical HLA loci (HLA-A, HLA-B, H
BACKGROUND & AIMS: Small duct primary sclerosing cholangitis (PSC) is phenotypically a mild version of large duct P …
Refinement of the MHC risk map in a scandinavian primary sclerosing cholangitis population.
Næss S, Lie BA, Melum E, Olsson M, Hov JR, Croucher PJ, Hampe J, Thorsby E, Bergquist A, Traherne JA, Schrumpf E, Boberg KM, Schreiber S, Franke A, Karlsen TH. Næss S, et al. PLoS One. 2014 Dec 18;9(12):e114486. doi: 10.1371/journal.pone.0114486. eCollection 2014. PLoS One. 2014. PMID: 25521205 Free PMC article.
BACKGROUND: Genetic variants within the major histocompatibility complex (MHC) represent the strongest genetic susceptibility factors for primary sclerosing cholangitis (PSC). Identifying the causal variants within this genetic complex represents a major chal …
BACKGROUND: Genetic variants within the major histocompatibility complex (MHC) represent the strongest genetic susceptibility factors for …
Sclerosing cholangitis.
Martins EB, Chapman RW. Martins EB, et al. Curr Opin Gastroenterol. 1999 Sep;15(5):436-41. doi: 10.1097/00001574-199909000-00011. Curr Opin Gastroenterol. 1999. PMID: 17023986
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease that progresses to death as a result of liver failure or cholangiocarcinoma. Susceptibility to PSC is associated with the HLA A1-B8-DR3 haplotype, and new associations with
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease that progresses to death as a result of liv