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1978 1
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1999 11
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2002 12
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HLA-Cw6 and psoriasis.
Chen L, Tsai TF. Chen L, et al. Br J Dermatol. 2018 Apr;178(4):854-862. doi: 10.1111/bjd.16083. Epub 2018 Mar 2. Br J Dermatol. 2018. PMID: 29072309 Review.
HLA-Cw6 is one of the most strongly associated psoriasis susceptibility alleles. ...Phenotypically, HLA-Cw6 has been found to be associated with guttate psoriasis. ...
HLA-Cw6 is one of the most strongly associated psoriasis susceptibility alleles. ...Phenotypically, HLA-Cw6 has been fo
HLA-C*06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis.
Dand N, Duckworth M, Baudry D, Russell A, Curtis CJ, Lee SH, Evans I, Mason KJ, Alsharqi A, Becher G, Burden AD, Goodwin RG, McKenna K, Murphy R, Perera GK, Rotarescu R, Wahie S, Wright A, Reynolds NJ, Warren RB, Griffiths CEM, Smith CH, Simpson MA, Barker JN; BADBIR Study Group; BSTOP Study Group; PSORT Consortium. Dand N, et al. J Allergy Clin Immunol. 2019 Jun;143(6):2120-2130. doi: 10.1016/j.jaci.2018.11.038. Epub 2018 Dec 20. J Allergy Clin Immunol. 2019. PMID: 30578879
Results from HLA-wide analyses were consistent with HLA-C*06:02 itself being the primary effect allele. We found no evidence for genetic interaction between HLA-C*06:02 and ERAP1. CONCLUSION: This large observational study suggests that referenc …
Results from HLA-wide analyses were consistent with HLA-C*06:02 itself being the primary effect allele. We found no evi …
HLA-Cw1 and Psoriasis.
Huang YW, Tsai TF. Huang YW, et al. Am J Clin Dermatol. 2021 Jan 18:1-9. doi: 10.1007/s40257-020-00585-1. Online ahead of print. Am J Clin Dermatol. 2021. PMID: 33460021 Free PMC article. Review.
In contrast, HLA-Cw1 positivity has been associated with erythrodermic psoriasis, pustular psoriasis, and the axial type of psoriatic arthritis. ...Given the diverse nature of psoriasis pathogenesis and the difference in HLA-Cw prevalence in dif …
In contrast, HLA-Cw1 positivity has been associated with erythrodermic psoriasis, pustular psoriasis, and the axial typ …
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2, Strange A, Capon F, Spencer CC, Knight J, Weale ME, Allen MH, Barton A, Band G, Bellenguez C, Bergboer JG, Blackwell JM, Bramon E, Bumpstead SJ, Casas JP, Cork MJ, Corvin A, Deloukas P, Dilthey A, Duncanson A, Edkins S, Estivill X, Fitzgerald O, Freeman C, Giardina E, Gray E, Hofer A, Hüffmeier U, Hunt SE, Irvine AD, Jankowski J, Kirby B, Langford C, Lascorz J, Leman J, Leslie S, Mallbris L, Markus HS, Mathew CG, McLean WH, McManus R, Mössner R, Moutsianas L, Naluai AT, Nestle FO, Novelli G, Onoufriadis A, Palmer CN, Perricone C, Pirinen M, Plomin R, Potter SC, Pujol RM, Rautanen A, Riveira-Munoz E, Ryan AW, Salmhofer W, Samuelsson L, Sawcer SJ, Schalkwijk J, Smith CH, Ståhle M, Su Z, Tazi-Ahnini R, Traupe H, Viswanathan AC, Warren RB, Weger W, Wolk K, Wood N, Worthington J, Young HS, Zeeuwen PL, Hayday A, Burden AD, Griffiths CE, Kere J, Reis A, McVean G, Evans DM, Brown MA, Barker JN, Peltonen L, Donnelly P, Trembath RC. Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2, et al. Nat Genet. 2010 Nov;42(11):985-90. doi: 10.1038/ng.694. Epub 2010 Oct 17. Nat Genet. 2010. PMID: 20953190 Free PMC article.
We also report compelling evidence for an interaction between the HLA-C and ERAP1 loci (combined P = 6.95 10-6). ERAP1 plays an important role in MHC class I peptide processing. ERAP1 variants only influenced psoriasis susceptibility in individuals carrying t …
We also report compelling evidence for an interaction between the HLA-C and ERAP1 loci (combined P = 6.95 10-6). ERAP1 plays a …
Hypermethylation of HLA-C may be an epigenetic marker in psoriasis.
Chen M, Wang Y, Yao X, Li C, Jiang M, Cui P, Wang B. Chen M, et al. J Dermatol Sci. 2016 Jul;83(1):10-6. doi: 10.1016/j.jdermsci.2016.04.003. Epub 2016 Apr 14. J Dermatol Sci. 2016. PMID: 27132688
The mean value of HLA-C mRNA expression is not relative to the promoter methylation of HLA-C in psoriatic lesions and non-lesions, respectively. CONCLUSIONS: We first demonstrate hypermethylation of HLA-C gene in psoriatic epidermis, sugg …
The mean value of HLA-C mRNA expression is not relative to the promoter methylation of HLA-C in psoriatic lesion …
The Genetics of Psoriasis and Psoriatic Arthritis.
O'Rielly DD, Jani M, Rahman P, Elder JT. O'Rielly DD, et al. J Rheumatol Suppl. 2019 Jun;95:46-50. doi: 10.3899/jrheum.190119. J Rheumatol Suppl. 2019. PMID: 31154404
Psoriatic arthritis (PsA) is an inflammatory arthritis that manifests in 20-30% of patients diagnosed with psoriasis. Epidemiologic studies suggest a substantial genetic contribution to PsA. There is a strong need for genome-wide association studies on patients with PsA, i …
Psoriatic arthritis (PsA) is an inflammatory arthritis that manifests in 20-30% of patients diagnosed with psoriasis. Epidemiologic s …
HLA-C and TNF gene polymorphisms are associated with psoriasis in Brazilian patients.
Cardili RN, Deghaide NS, Mendes-Junior CT, Donadi EA, Souza CS. Cardili RN, et al. Int J Dermatol. 2016 Jan;55(1):e16-22. doi: 10.1111/ijd.12894. Epub 2015 Oct 15. Int J Dermatol. 2016. PMID: 26470763
BACKGROUND: Polymorphisms at the human leukocyte antigens (HLA-C) and tumor necrosis factor (TNF) genes have been associated with susceptibility to psoriasis in several worldwide populations. ...No association between HLA-C*06 and psor
BACKGROUND: Polymorphisms at the human leukocyte antigens (HLA-C) and tumor necrosis factor (TNF) genes have been assoc …
Melanocytes: Target Cells of an HLA-C*06:02-Restricted Autoimmune Response in Psoriasis.
Prinz JC. Prinz JC. J Invest Dermatol. 2017 Oct;137(10):2053-2058. doi: 10.1016/j.jid.2017.05.023. J Invest Dermatol. 2017. PMID: 28941475 Free article. Review.
HLA-C*06:02 is the main psoriasis risk allele. By the unbiased analysis of a Valpha3S1/Vbeta13S1 T-cell receptor from pathogenic psoriatic CD8(+) T cells, we had recently proven that HLA-C*06:02 directs an autoimmune response against melanocytes
HLA-C*06:02 is the main psoriasis risk allele. By the unbiased analysis of a Valpha3S1/Vbeta13S1 T-cell receptor from p
ERAP1 and HLA-C*06 are strongly associated with the risk of psoriasis in the population of northern Poland.
Stawczyk-Macieja M, Szczerkowska-Dobosz A, Rębała K, Gabig-Cimińska M, Nowicki RJ, Haraś A, Cybulska L, Kapińska E. Stawczyk-Macieja M, et al. Postepy Dermatol Alergol. 2018 Jun;35(3):286-292. doi: 10.5114/ada.2018.76226. Epub 2018 Jun 18. Postepy Dermatol Alergol. 2018. PMID: 30008647 Free PMC article.
INTRODUCTION: HLA-C*06 is a major psoriasis genetic risk marker. Recent reports have been focused on the role of different polymorphisms within genes involved in the functioning of the epidermal barrier and antigen processing in the pathogenesis of psorias
INTRODUCTION: HLA-C*06 is a major psoriasis genetic risk marker. Recent reports have been focused on the role of differ …
HLA-C*12:02 is a susceptibility factor in late-onset type of psoriasis in Japanese.
Mabuchi T, Ota T, Manabe Y, Ikoma N, Ozawa A, Terui T, Ikeda S, Inoko H, Oka A. Mabuchi T, et al. J Dermatol. 2014 Aug;41(8):697-704. doi: 10.1111/1346-8138.12569. J Dermatol. 2014. PMID: 25099155
The HLA-C locus on chromosome 6p21.33 remains the strongest susceptibility candidate locus in psoriasis. ...We confirmed the association between early-onset type of psoriasis with HLA-C*06:02 allele in Japanese. In addition, we detected t …
The HLA-C locus on chromosome 6p21.33 remains the strongest susceptibility candidate locus in psoriasis. ...We confirme …
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