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98 results
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Page 1
HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry.
Henriksen EKK, Viken MK, Wittig M, Holm K, Folseraas T, Mucha S, Melum E, Hov JR, Lazaridis KN, Juran BD, Chazouillères O, Färkkilä M, Gotthardt DN, Invernizzi P, Carbone M, Hirschfield GM, Rushbrook SM, Goode E; UK-PSC Consortium, Ponsioen CY, Weersma RK, Eksteen B, Yimam KK, Gordon SC, Goldberg D, Yu L, Bowlus CL, Franke A, Lie BA, Karlsen TH. Henriksen EKK, et al. HLA. 2017 Oct;90(4):228-233. doi: 10.1111/tan.13076. Epub 2017 Jul 11. HLA. 2017. PMID: 28695657 Free PMC article.
Primary sclerosing cholangitis (PSC) is strongly associated with several human leukocyte antigen (HLA) haplotypes. ...We aimed to evaluate whether studying populations of admixed or non-European descent could help in defining the causative HLA a
Primary sclerosing cholangitis (PSC) is strongly associated with several human leukocyte antigen (HLA) haplotype
Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis.
Hov JR, Boberg KM, Taraldsrud E, Vesterhus M, Boyadzhieva M, Solberg IC, Schrumpf E, Vatn MH, Lie BA, Molberg Ø, Karlsen TH. Hov JR, et al. Liver Int. 2017 Mar;37(3):458-465. doi: 10.1111/liv.13238. Epub 2016 Sep 13. Liver Int. 2017. PMID: 27558072
BACKGROUND & AIMS: The strongest genetic risk factors in primary sclerosing cholangitis (PSC) are encoded in the HLA complex. ...METHODS: Antineutrophil cytoplasmic antibodies were analysed with indirect immunofluorescence in 241 Norwegian PSC pati …
BACKGROUND & AIMS: The strongest genetic risk factors in primary sclerosing cholangitis (PSC) are encoded in the …
Etiology and pathogenesis in primary sclerosing cholangitis.
Boberg KM, Lundin KE, Schrumpf E. Boberg KM, et al. Scand J Gastroenterol Suppl. 1994;204:47-58. doi: 10.3109/00365529409103625. Scand J Gastroenterol Suppl. 1994. PMID: 7824878 Review.
The etiology and pathogenesis of the inflammatory and fibrotic bile duct lesions characteristic of primary sclerosing cholangitis (PSC) is unknown, but several lines of evidence support the contention that genetic and immunologic factors are involved. ...Ther …
The etiology and pathogenesis of the inflammatory and fibrotic bile duct lesions characteristic of primary sclerosing chola
Factors Associated With Outcomes of Patients With Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System.
Goode EC, Clark AB, Mells GF, Srivastava B, Spiess K, Gelson WTH, Trivedi PJ, Lynch KD, Castren E, Vesterhus MN, Karlsen TH, Ji SG, Anderson CA, Thorburn D, Hudson M, Heneghan MA, Aldersley MA, Bathgate A, Sandford RN, Alexander GJ, Chapman RW, Walmsley M; UK-PSC Consortium, Hirschfield GM, Rushbrook SM. Goode EC, et al. Hepatology. 2019 May;69(5):2120-2135. doi: 10.1002/hep.30479. Epub 2019 Mar 4. Hepatology. 2019. PMID: 30566748 Free PMC article.
We sought to identify factors that are predictive of liver transplantation or death in patients with primary sclerosing cholangitis (PSC), and to develop and validate a contemporaneous risk score for use in a real-world clinical setting. ...Although heterozyg …
We sought to identify factors that are predictive of liver transplantation or death in patients with primary sclerosing cho
Genetic associations in Italian primary sclerosing cholangitis: heterogeneity across Europe defines a critical role for HLA-C.
Hov JR, Lleo A, Selmi C, Woldseth B, Fabris L, Strazzabosco M, Karlsen TH, Invernizzi P. Hov JR, et al. J Hepatol. 2010 May;52(5):712-7. doi: 10.1016/j.jhep.2009.11.029. Epub 2010 Mar 4. J Hepatol. 2010. PMID: 20347497
BACKGROUND & AIMS: The HLA complex on chromosome 6p21 is firmly established as a risk locus for primary sclerosing cholangitis (PSC). ...METHODS: Seventy-eight North-Italian PSC patients and 79 controls were included. We performed sequencing-based …
BACKGROUND & AIMS: The HLA complex on chromosome 6p21 is firmly established as a risk locus for primary sclerosing
Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes.
Wiencke K, Karlsen TH, Boberg KM, Thorsby E, Schrumpf E, Lie BA, Spurkland A. Wiencke K, et al. Tissue Antigens. 2007 Feb;69(2):161-9. doi: 10.1111/j.1399-0039.2006.00738.x. Tissue Antigens. 2007. PMID: 17257319
Primary sclerosing cholangitis (PSC) is associated with the human leukocyte antigen (HLA)-DRB1*0301-DQA1*0501-DQB1*0201 (DR3) and HLA-DRB1*1301-DQA1*0103-DQB1*0603 (DR6) haplotypes. Recently, the extended HLA class I region has been found
Primary sclerosing cholangitis (PSC) is associated with the human leukocyte antigen (HLA)-DRB1*0301-DQA1*0501-DQ
Electrostatic modifications of the human leukocyte antigen-DR P9 peptide-binding pocket and susceptibility to primary sclerosing cholangitis.
Hov JR, Kosmoliaptsis V, Traherne JA, Olsson M, Boberg KM, Bergquist A, Schrumpf E, Bradley JA, Taylor CJ, Lie BA, Trowsdale J, Karlsen TH. Hov JR, et al. Hepatology. 2011 Jun;53(6):1967-76. doi: 10.1002/hep.24299. Epub 2011 May 13. Hepatology. 2011. PMID: 21413052 Free PMC article.
The strongest genetic risk factors for primary sclerosing cholangitis (PSC) are found in the human leukocyte antigen (HLA) complex at chromosome 6p21. ...The aim of this study was to analyze the structure and electrostatic properties of the peptide-bin …
The strongest genetic risk factors for primary sclerosing cholangitis (PSC) are found in the human leukocyte antigen ( …
Primary sclerosing cholangitis in genetically diverse populations listed for liver transplantation: unique clinical and human leukocyte antigen associations.
Bowlus CL, Li CS, Karlsen TH, Lie BA, Selmi C. Bowlus CL, et al. Liver Transpl. 2010 Nov;16(11):1324-30. doi: 10.1002/lt.22161. Liver Transpl. 2010. PMID: 21031548 Free PMC article.
Primary sclerosing cholangitis (PSC) is well characterized in European populations. ...However, HLA-DR3, which is in linkage disequilibrium with HLA-B8, showed associations only in European Americans and Hispanics. ...
Primary sclerosing cholangitis (PSC) is well characterized in European populations. ...However, HLA-DR3, which i
HLA-DR and HLA-DQ are not markers for rapid disease progression in primary sclerosing cholangitis.
Olerup O, Olsson R, Hultcrantz R, Broome U. Olerup O, et al. Gastroenterology. 1995 Mar;108(3):870-8. doi: 10.1016/0016-5085(95)90463-8. Gastroenterology. 1995. PMID: 7875491
BACKGROUND/AIMS: The association between primary sclerosing cholangitis (PSC) and the HLA haplotype A1, B8, DR3, DQ2 is well established. ...Our aim was to critically evaluate all of the current and as yet mostly unconfirmed HLA class II issues …
BACKGROUND/AIMS: The association between primary sclerosing cholangitis (PSC) and the HLA haplotype A1, B8, DR3, …
Association Between HLA Haplotypes and Increased Serum Levels of IgG4 in Patients With Primary Sclerosing Cholangitis.
Berntsen NL, Klingenberg O, Juran BD, Benito de Valle M, Lindkvist B, Lazaridis KN, Boberg KM, Karlsen TH, Hov JR. Berntsen NL, et al. Gastroenterology. 2015 May;148(5):924-927.e2. doi: 10.1053/j.gastro.2015.01.041. Epub 2015 Feb 2. Gastroenterology. 2015. PMID: 25655558 Free PMC article.
Increased serum levels of IgG4 have been reported in 9%-15% of patients with primary sclerosing cholangitis (PSC); it is not clear whether this increase contributes to pathogenesis. ...We found an association between levels of IgG4 above the upper reference l …
Increased serum levels of IgG4 have been reported in 9%-15% of patients with primary sclerosing cholangitis (PSC); it i …
98 results