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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 2
1996 2
1997 8
1998 9
1999 8
2000 18
2001 19
2002 32
2003 23
2004 32
2005 49
2006 62
2007 43
2008 57
2009 70
2010 70
2011 91
2012 92
2013 104
2014 111
2015 115
2016 134
2017 112
2018 129
2019 134
2020 102
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1,450 results
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Page 1
Maturity-onset diabetes of the young (MODY): an update.
Anık A, Çatlı G, Abacı A, Böber E. Anık A, et al. J Pediatr Endocrinol Metab. 2015 Mar;28(3-4):251-63. doi: 10.1515/jpem-2014-0384. J Pediatr Endocrinol Metab. 2015. PMID: 25581748 Review.
However, mutations in the HNF1A and HNF4A cause a progressive pancreatic β-cell dysfunction and hyperglycemia that can result in microvascular complications. ...
However, mutations in the HNF1A and HNF4A cause a progressive pancreatic β-cell dysfunction and hyperglycemia that can result in micr …
Precision diabetes: learning from monogenic diabetes.
Hattersley AT, Patel KA. Hattersley AT, et al. Diabetologia. 2017 May;60(5):769-777. doi: 10.1007/s00125-017-4226-2. Epub 2017 Mar 17. Diabetologia. 2017. PMID: 28314945 Free PMC article. Review.
The Diagnosis and Management of Hyperinsulinaemic Hypoglycaemia.
Roženková K, Güemes M, Shah P, Hussain K. Roženková K, et al. J Clin Res Pediatr Endocrinol. 2015 Jun;7(2):86-97. doi: 10.4274/jcrpe.1891. J Clin Res Pediatr Endocrinol. 2015. PMID: 26316429 Free PMC article. Review.
Recent advances in genetics have linked CHI to mutations in 9 genes that play a key role in regulating insulin secretion (ABCC8, KCNJ11, GLUD1, GCK, HADH, SLC16A1, UCP2, HNF4A and HNF1A). ...
Recent advances in genetics have linked CHI to mutations in 9 genes that play a key role in regulating insulin secretion (ABCC8, KCNJ11, GLU …
circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma.
Zhang X, Xu Y, Qian Z, Zheng W, Wu Q, Chen Y, Zhu G, Liu Y, Bian Z, Xu W, Zhang Y, Sun F, Pan Q, Wang J, Du L, Yu Y. Zhang X, et al. Cell Death Dis. 2018 Oct 25;9(11):1091. doi: 10.1038/s41419-018-1132-6. Cell Death Dis. 2018. PMID: 30361504 Free PMC article.
Mechanistically, HNF4a bound to the -1409 to -1401 region of the circ_104075 promoter to stimulate the expression of circ_104075. ...
Mechanistically, HNF4a bound to the -1409 to -1401 region of the circ_104075 promoter to stimulate the expression of circ_104075. ...
Ferroptosis is governed by differential regulation of transcription in liver cancer.
Zhang X, Du L, Qiao Y, Zhang X, Zheng W, Wu Q, Chen Y, Zhu G, Liu Y, Bian Z, Guo S, Yang Y, Ma L, Yu Y, Pan Q, Sun F, Wang J. Zhang X, et al. Redox Biol. 2019 Jun;24:101211. doi: 10.1016/j.redox.2019.101211. Epub 2019 May 10. Redox Biol. 2019. PMID: 31108460 Free PMC article.
Clinically, HIC1 and HNF4A conversely correlate with tumor stage in liver cancer. Patients with lower HIC1 and higher HNF4A exhibit poorer prognostic outcomes. Disrupting the balance between HIC1 and HNF4A might be helpful in treating liver cancer....
Clinically, HIC1 and HNF4A conversely correlate with tumor stage in liver cancer. Patients with lower HIC1 and higher HNF4A ex …
Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome.
Marable SS, Chung E, Adam M, Potter SS, Park JS. Marable SS, et al. JCI Insight. 2018 Jul 26;3(14):e97497. doi: 10.1172/jci.insight.97497. eCollection 2018 Jul 26. JCI Insight. 2018. PMID: 30046000 Free PMC article.
It has been shown that a mutation in HNF4A is associated with FRTS in humans and that Hnf4a is expressed specifically in proximal tubules in adult rat nephrons. However, little is known about the role of Hnf4a in nephrogenesis. Here, we found that Hnf4a
It has been shown that a mutation in HNF4A is associated with FRTS in humans and that Hnf4a is expressed specifically in proxi …
New IBD genetics: common pathways with other diseases.
Lees CW, Barrett JC, Parkes M, Satsangi J. Lees CW, et al. Gut. 2011 Dec;60(12):1739-53. doi: 10.1136/gut.2009.199679. Epub 2011 Feb 7. Gut. 2011. PMID: 21300624 Review.
Genetic evidence has also demonstrated the importance of barrier function to the development of ulcerative colitis (HNF4A, LAMB1, CDH1 and GNA12). ...
Genetic evidence has also demonstrated the importance of barrier function to the development of ulcerative colitis (HNF4A, LAMB1, CDH …
Hepatocyte Nuclear Factor 4-Alpha Is Essential for the Active Epigenetic State at Enhancers in Mouse Liver.
Thakur A, Wong JCH, Wang EY, Lotto J, Kim D, Cheng JC, Mingay M, Cullum R, Moudgil V, Ahmed N, Tsai SH, Wei W, Walsh CP, Stephan T, Bilenky M, Fuglerud BM, Karimi MM, Gonzalez FJ, Hirst M, Hoodless PA. Thakur A, et al. Hepatology. 2019 Oct;70(4):1360-1376. doi: 10.1002/hep.30631. Epub 2019 May 15. Hepatology. 2019. PMID: 30933372 Free PMC article.
In mice lacking HNF4A protein in hepatocytes, we observed a decrease in both H3K27ac and hydroxymethylation at regions bound by HNF4A. ...Furthermore, HNF4A regulates TET3 expression in liver by directly binding to an enhancer region. Conclusion: In conclusio …
In mice lacking HNF4A protein in hepatocytes, we observed a decrease in both H3K27ac and hydroxymethylation at regions bound by HN
HNF4 Regulates Fatty Acid Oxidation and Is Required for Renewal of Intestinal Stem Cells in Mice.
Chen L, Vasoya RP, Toke NH, Parthasarathy A, Luo S, Chiles E, Flores J, Gao N, Bonder EM, Su X, Verzi MP. Chen L, et al. Gastroenterology. 2020 Mar;158(4):985-999.e9. doi: 10.1053/j.gastro.2019.11.031. Epub 2019 Nov 22. Gastroenterology. 2020. PMID: 31759926
HNF4A and HNF4G were expressed in ISCs and throughout the intestinal epithelium. Single knockout of either HNF4A or HNF4G did not affect maintenance of ISCs, but double-knockout of HNF4A and HNF4G resulted in ISC loss; stem cells failed to renew. ...CONCLUSIO
HNF4A and HNF4G were expressed in ISCs and throughout the intestinal epithelium. Single knockout of either HNF4A or HNF4G did
Clinicopathological Characteristics and Mutations Driving Development of Early Lung Adenocarcinoma: Tumor Initiation and Progression.
Inamura K. Inamura K. Int J Mol Sci. 2018 Apr 23;19(4):1259. doi: 10.3390/ijms19041259. Int J Mol Sci. 2018. PMID: 29690599 Free PMC article. Review.
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