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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 1
1991 6
1992 22
1993 50
1994 135
1995 339
1996 549
1997 640
1998 821
1999 1001
2000 1166
2001 1244
2002 1252
2003 1246
2004 1345
2005 1364
2006 1410
2007 1403
2008 1415
2009 1343
2010 1374
2011 1477
2012 1433
2013 1414
2014 1378
2015 1411
2016 1330
2017 1302
2018 1235
2019 1223
2020 1288
2021 91
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29,046 results
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Page 1
IL-12 family cytokines: immunological playmakers.
Vignali DA, Kuchroo VK. Vignali DA, et al. Nat Immunol. 2012 Jul 19;13(8):722-8. doi: 10.1038/ni.2366. Nat Immunol. 2012. PMID: 22814351 Free PMC article. Review.
The interleukin 12 (IL-12) family is unique in having the only heterodimeric cytokines, including IL-12, IL-23, IL-27 and IL-35. ...Despite sharing many structural features and molecular partners, cytokines of the …
The interleukin 12 (IL-12) family is unique in having the only heterodimeric cytokines, including IL-1 …
Interleukin (IL)-12 and IL-23 and Their Conflicting Roles in Cancer.
Yan J, Smyth MJ, Teng MWL. Yan J, et al. Cold Spring Harb Perspect Biol. 2018 Jul 2;10(7):a028530. doi: 10.1101/cshperspect.a028530. Cold Spring Harb Perspect Biol. 2018. PMID: 28716888 Free PMC article. Review.
The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the development of antitumor or protumor immunity. In this review, we discuss the role IL-12 and IL-23 plays in tumor biology from p …
The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the developme …
IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases.
Teng MW, Bowman EP, McElwee JJ, Smyth MJ, Casanova JL, Cooper AM, Cua DJ. Teng MW, et al. Nat Med. 2015 Jul;21(7):719-29. doi: 10.1038/nm.3895. Epub 2015 Jun 29. Nat Med. 2015. PMID: 26121196 Review.
The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell-mediated responses in inflammation for more than a decade after it was first identified. Discovery of the cytokine IL-23, which shares a common p40 subunit with …
The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell-mediated responses in inflammat …
Impact of IL-12 in Cancer.
Lu X. Lu X. Curr Cancer Drug Targets. 2017;17(8):682-697. doi: 10.2174/1568009617666170427102729. Curr Cancer Drug Targets. 2017. PMID: 28460617 Review.
BACKGROUND: Interleukin 12 (IL-12) is a pleiotropic cytokine that plays an essential role in Th1-type immune response against cancer, a condition where cells in a particular part of the body grow and reproduce uncontrollably. METHODS: In this review, w …
BACKGROUND: Interleukin 12 (IL-12) is a pleiotropic cytokine that plays an essential role in Th1-type immune res …
New insights into the IL-12 and IL-23: From a molecular basis to clinical application in immune-mediated inflammation and cancers.
Chyuan IT, Lai JH. Chyuan IT, et al. Biochem Pharmacol. 2020 May;175:113928. doi: 10.1016/j.bcp.2020.113928. Epub 2020 Mar 23. Biochem Pharmacol. 2020. PMID: 32217101 Review.
The cytokines interleukin-12 (IL-12) and IL-23 share a common IL-12/IL-23p40 subunit in structure and play a central role in T cell-mediated responses in inflammation. ...More recently, it has been addressed that the balance …
The cytokines interleukin-12 (IL-12) and IL-23 share a common IL-12/IL-23p40 subunit …
IL-12 Family Cytokines: General Characteristics, Pathogenic Microorganisms, Receptors, and Signalling Pathways.
Behzadi P, Behzadi E, Ranjbar R. Behzadi P, et al. Acta Microbiol Immunol Hung. 2016 Mar;63(1):1-25. doi: 10.1556/030.63.2016.1.1. Acta Microbiol Immunol Hung. 2016. PMID: 27020866 Review.
Among a wide range of cytokines, the Interleukin 12 (IL-12) family has its unique structural, functional, and immunological characteristics that have made this family as important immunological playmakers. ...IL-12 and IL-23 are si …
Among a wide range of cytokines, the Interleukin 12 (IL-12) family has its unique structural, functional, and im …
Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline.
Vom Berg J, Prokop S, Miller KR, Obst J, Kälin RE, Lopategui-Cabezas I, Wegner A, Mair F, Schipke CG, Peters O, Winter Y, Becher B, Heppner FL. Vom Berg J, et al. Nat Med. 2012 Dec;18(12):1812-9. doi: 10.1038/nm.2965. Epub 2012 Nov 25. Nat Med. 2012. PMID: 23178247
Using the APPPS1 Alzheimer's disease mouse model, we found increased production of the common interleukin-12 (IL-12) and IL-23 subunit p40 by microglia. Genetic ablation of the IL-12/IL-23 signaling molecules p40, p35 or p19 …
Using the APPPS1 Alzheimer's disease mouse model, we found increased production of the common interleukin-12 (IL-12 …
New insights into IL-12-mediated tumor suppression.
Tugues S, Burkhard SH, Ohs I, Vrohlings M, Nussbaum K, Vom Berg J, Kulig P, Becher B. Tugues S, et al. Cell Death Differ. 2015 Feb;22(2):237-46. doi: 10.1038/cdd.2014.134. Epub 2014 Sep 5. Cell Death Differ. 2015. PMID: 25190142 Free PMC article. Review.
During the past two decades, interleukin-12 (IL-12) has emerged as one of the most potent cytokines in mediating antitumor activity in a variety of preclinical models. ...Here we discuss the therapeutic effects of IL-12 from preclinical t …
During the past two decades, interleukin-12 (IL-12) has emerged as one of the most potent cytokines in mediating …
Interleukin-12 and the regulation of innate resistance and adaptive immunity.
Trinchieri G. Trinchieri G. Nat Rev Immunol. 2003 Feb;3(2):133-46. doi: 10.1038/nri1001. Nat Rev Immunol. 2003. PMID: 12563297 Review.
Interleukin-12 (IL-12) is a heterodimeric pro-inflammatory cytokine that induces the production of interferon-gamma (IFN-gamma), favours the differentiation of T helper 1 (T(H)1) cells and forms a link between innate resistance and adaptive immunity. D …
Interleukin-12 (IL-12) is a heterodimeric pro-inflammatory cytokine that induces the production of interferon-ga …
Is IL-12 pro-inflammatory or anti-inflammatory? Depends on the blood pressure.
Balasubbramanian D, Goodlett BL, Mitchell BM. Balasubbramanian D, et al. Cardiovasc Res. 2019 May 1;115(6):998-999. doi: 10.1093/cvr/cvz028. Cardiovasc Res. 2019. PMID: 30698673 No abstract available.
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