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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
1979 1
1992 1
1994 5
1995 42
1996 91
1997 109
1998 142
1999 147
2000 178
2001 203
2002 227
2003 231
2004 239
2005 275
2006 282
2007 281
2008 304
2009 313
2010 327
2011 358
2012 344
2013 342
2014 352
2015 327
2016 368
2017 350
2018 390
2019 360
2020 412
2021 31
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6,358 results
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Page 1
Immunobiology of the IL-15/IL-15Ralpha complex as an antitumor and antiviral agent.
Guo Y, Luan L, Patil NK, Sherwood ER. Guo Y, et al. Cytokine Growth Factor Rev. 2017 Dec;38:10-21. doi: 10.1016/j.cytogfr.2017.08.002. Epub 2017 Sep 1. Cytokine Growth Factor Rev. 2017. PMID: 28888485 Free PMC article. Review.
Recently, the creation of IL-15 superagonist by complexing IL-15 and its high affinity receptor alpha (IL-15 Ralpha) in solution, inspired by the natural trans-presentation of IL-15, advances the potential of IL-15
Recently, the creation of IL-15 superagonist by complexing IL-15 and its high affinity receptor alpha (IL
Interleukin 15: A key cytokine for immunotherapy.
Patidar M, Yadav N, Dalai SK. Patidar M, et al. Cytokine Growth Factor Rev. 2016 Oct;31:49-59. doi: 10.1016/j.cytogfr.2016.06.001. Epub 2016 Jun 7. Cytokine Growth Factor Rev. 2016. PMID: 27325459 Review.
Interleukin (IL)-15, a member of the immunoregulatory cytokines family, is a pluripotent molecule with therapeutic potential. ...In addition, IL-15 can be targeted by antibody- or mutant IL-15 therapy to reduce inflammation. ...
Interleukin (IL)-15, a member of the immunoregulatory cytokines family, is a pluripotent molecule with therapeutic pote
Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.
Ring AM, Lin JX, Feng D, Mitra S, Rickert M, Bowman GR, Pande VS, Li P, Moraga I, Spolski R, Ozkan E, Leonard WJ, Garcia KC. Ring AM, et al. Nat Immunol. 2012 Dec;13(12):1187-95. doi: 10.1038/ni.2449. Epub 2012 Oct 28. Nat Immunol. 2012. PMID: 23104097 Free PMC article.
Interleukin 15 (IL-15) and IL-2 have distinct immunological functions even though both signal through the receptor subunit IL-2Rbeta and the common gamma-chain (gamma(c)). ...IL-15Ralpha substantially increased the affinity of I
Interleukin 15 (IL-15) and IL-2 have distinct immunological functions even though both signal through the
Control of memory CD8(+) T cell longevity and effector functions by IL-15.
Nolz JC, Richer MJ. Nolz JC, et al. Mol Immunol. 2020 Jan;117:180-188. doi: 10.1016/j.molimm.2019.11.011. Epub 2019 Dec 6. Mol Immunol. 2020. PMID: 31816491 Free PMC article. Review.
IL-15 is a member of the common gamma chain family of cytokines and plays important roles in regulating several aspects of innate and adaptive immunity. ...Here, we discuss how IL-15 is critical in regulating many functions of memory CD8(+) T cells and
IL-15 is a member of the common gamma chain family of cytokines and plays important roles in regulating several aspects of inn
IL-15 regulates fibrosis and inflammation in a mouse model of chronic pancreatitis.
Manohar M, Kandikattu HK, Verma AK, Mishra A. Manohar M, et al. Am J Physiol Gastrointest Liver Physiol. 2018 Dec 1;315(6):G954-G965. doi: 10.1152/ajpgi.00139.2018. Epub 2018 Sep 13. Am J Physiol Gastrointest Liver Physiol. 2018. PMID: 30212254 Free PMC article.
Pancreatitis is an inflammatory disease characterized by the induction of several proinflammatory cytokines like interleukin (IL)-6, IL-8, IL-1beta, and IL-1. Recently, the multifunctional innate cytokine IL-15 has been implicated …
Pancreatitis is an inflammatory disease characterized by the induction of several proinflammatory cytokines like interleukin (IL
Interleukin-15 in cancer immunotherapy: IL-15 receptor complex versus soluble IL-15 in a cancer cell-delivered murine leukemia model.
Berger A, Colpitts SJ, Seabrook MSS, Furlonger CL, Bendix MB, Moreau JM, McKillop WM, Medin JA, Paige CJ. Berger A, et al. J Immunother Cancer. 2019 Dec 19;7(1):355. doi: 10.1186/s40425-019-0777-8. J Immunother Cancer. 2019. PMID: 31856922 Free PMC article.
IL-15, either in its soluble form (IL-15sol) or complexed with IL-15Ralpha (IL-15Rc), has been shown to exhibit potent anti-tumor activities in various experimental cancer studies. Here we describe the impact of intraperitoneal IL-15
IL-15, either in its soluble form (IL-15sol) or complexed with IL-15Ralpha (IL-15Rc), has been shown to e
Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins.
Mortier E, Quéméner A, Vusio P, Lorenzen I, Boublik Y, Grötzinger J, Plet A, Jacques Y. Mortier E, et al. J Biol Chem. 2006 Jan 20;281(3):1612-9. doi: 10.1074/jbc.M508624200. Epub 2005 Nov 11. J Biol Chem. 2006. PMID: 16284400 Free article.
Interleukin-15 (IL-15) is crucial for the generation of multiple lymphocyte subsets (natural killer (NK), NK-T cells, and memory CD8 T cells), and transpresentation of IL-15 by monocytes and dendritic cells has been suggested to be the do
Interleukin-15 (IL-15) is crucial for the generation of multiple lymphocyte subsets (natural killer (NK), NK-T c
Mystery Solved: IL-15.
Fehniger TA. Fehniger TA. J Immunol. 2019 Jun 1;202(11):3125-3126. doi: 10.4049/jimmunol.1900419. J Immunol. 2019. PMID: 31109944 Free article. No abstract available.
Cell-Based IL-15:IL-15Ralpha Secreting Vaccine as an Effective Therapy for CT26 Colon Cancer in Mice.
Thi VAD, Jeon HM, Park SM, Lee H, Kim YS. Thi VAD, et al. Mol Cells. 2019 Dec 31;42(12):869-883. doi: 10.14348/molcells.2019.0188. Mol Cells. 2019. PMID: 31760731 Free PMC article.
Interleukin (IL)-15 is an essential immune-modulator with high potential for use in cancer treatment. ...IL-15Ralpha, a member of the IL-15 receptor complex, is famous for its high affinity to IL-15 and its ability to length
Interleukin (IL)-15 is an essential immune-modulator with high potential for use in cancer treatment. ...IL-15Ra
IL-15 Expression Pattern in Atopic Dermatitis.
Karlen H, Yousefi S, Simon HU, Simon D. Karlen H, et al. Int Arch Allergy Immunol. 2020;181(6):417-421. doi: 10.1159/000508515. Epub 2020 May 18. Int Arch Allergy Immunol. 2020. PMID: 32422638
In AD, an increase in the relative numbers of IL-15 expressing CD1a+ DC, macrophages, and fibroblasts was noted. ...IL-15 may serve as a therapeutic target for AD....
In AD, an increase in the relative numbers of IL-15 expressing CD1a+ DC, macrophages, and fibroblasts was noted. ...IL- …
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