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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2000 1
2002 2
2003 3
2004 2
2005 6
2006 13
2007 27
2008 54
2009 48
2010 65
2011 89
2012 94
2013 86
2014 97
2015 111
2016 107
2017 115
2018 133
2019 119
2020 94
2021 10
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1,120 results
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Interleukin-17 inhibition: role in psoriasis and inflammatory bowel disease.
Hohenberger M, Cardwell LA, Oussedik E, Feldman SR. Hohenberger M, et al. J Dermatolog Treat. 2018 Feb;29(1):13-18. doi: 10.1080/09546634.2017.1329511. Epub 2017 May 31. J Dermatolog Treat. 2018. PMID: 28521565 Review.
Exacerbations of inflammatory bowel disease have been reported in anti-IL-17 psoriasis trials. ...Search terms included IL-17, psoriasis, inflammatory bowel disease, secukinumab, ixekizumab and brodalumab. ...
Exacerbations of inflammatory bowel disease have been reported in anti-IL-17 psoriasis trials. ...Search …
Th17 Cells and the IL-23/IL-17 Axis in the Pathogenesis of Periodontitis and Immune-Mediated Inflammatory Diseases.
Bunte K, Beikler T. Bunte K, et al. Int J Mol Sci. 2019 Jul 10;20(14):3394. doi: 10.3390/ijms20143394. Int J Mol Sci. 2019. PMID: 31295952 Free PMC article. Review.
Any dysregulation of this interaction can result in chronic inflammation and autoimmunity and is thought to be a major underlying cause in the initiation and progression of highly prevalent immune-mediated inflammatory diseases (IMIDs) such as psoriasis, rheumatoid …
Any dysregulation of this interaction can result in chronic inflammation and autoimmunity and is thought to be a major underlying cause in t …
Critical role of interleukin (IL)-17 in inflammatory and immune disorders: An updated review of the evidence focusing in controversies.
Ruiz de Morales JMG, Puig L, Daudén E, Cañete JD, Pablos JL, Martín AO, Juanatey CG, Adán A, Montalbán X, Borruel N, Ortí G, Holgado-Martín E, García-Vidal C, Vizcaya-Morales C, Martín-Vázquez V, González-Gay MÁ. Ruiz de Morales JMG, et al. Autoimmun Rev. 2020 Jan;19(1):102429. doi: 10.1016/j.autrev.2019.102429. Epub 2019 Nov 15. Autoimmun Rev. 2020. PMID: 31734402 Free article. Review.
Interleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of intensive research because of its crucial role in the pathogenesis of different diseases across many medical specialties. ...A comprehensive review of the literature
Interleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of intensive research because of it
Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis.
Smillie CS, Biton M, Ordovas-Montanes J, Sullivan KM, Burgin G, Graham DB, Herbst RH, Rogel N, Slyper M, Waldman J, Sud M, Andrews E, Velonias G, Haber AL, Jagadeesh K, Vickovic S, Yao J, Stevens C, Dionne D, Nguyen LT, Villani AC, Hofree M, Creasey EA, Huang H, Rozenblatt-Rosen O, Garber JJ, Khalili H, Desch AN, Daly MJ, Ananthakrishnan AN, Shalek AK, Xavier RJ, Regev A. Smillie CS, et al. Cell. 2019 Jul 25;178(3):714-730.e22. doi: 10.1016/j.cell.2019.06.029. Cell. 2019. PMID: 31348891 Free PMC article.
Inflammatory fibroblasts, inflammatory monocytes, microfold-like cells, and T cells that co-express CD8 and IL-17 expand with disease, forming intercellular interaction hubs. ...Our work provides a framework for interrogating complex human di
Inflammatory fibroblasts, inflammatory monocytes, microfold-like cells, and T cells that co-express CD8 and IL-17
Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease.
Lee JY, Hall JA, Kroehling L, Wu L, Najar T, Nguyen HH, Lin WY, Yeung ST, Silva HM, Li D, Hine A, Loke P, Hudesman D, Martin JC, Kenigsberg E, Merad M, Khanna KM, Littman DR. Lee JY, et al. Cell. 2020 Jan 9;180(1):79-91.e16. doi: 10.1016/j.cell.2019.11.026. Epub 2019 Dec 19. Cell. 2020. PMID: 31866067 Free PMC article.
Lymphoid cells that produce interleukin (IL)-17 cytokines protect barrier tissues from pathogenic microbes but are also prominent effectors of inflammation and autoimmune disease. T helper 17 (Th17) cells, defined by RORgammat-dependent producti …
Lymphoid cells that produce interleukin (IL)-17 cytokines protect barrier tissues from pathogenic microbes but are also …
IL-12, IL-23 and IL-17 in IBD: immunobiology and therapeutic targeting.
Moschen AR, Tilg H, Raine T. Moschen AR, et al. Nat Rev Gastroenterol Hepatol. 2019 Mar;16(3):185-196. doi: 10.1038/s41575-018-0084-8. Nat Rev Gastroenterol Hepatol. 2019. PMID: 30478416 Review.
IL-12 and IL-23 are closely related cytokines with important roles in the regulation of tissue inflammation. ...We review the emerging understanding of the biology of IL-12 and IL-23, as well as that of their major downstream cytokines, including IL
IL-12 and IL-23 are closely related cytokines with important roles in the regulation of tissue inflammation. ...We review the
Inflammatory bowel diseases and spondyloarthropathies: From pathogenesis to treatment.
Fragoulis GE, Liava C, Daoussis D, Akriviadis E, Garyfallos A, Dimitroulas T. Fragoulis GE, et al. World J Gastroenterol. 2019 May 14;25(18):2162-2176. doi: 10.3748/wjg.v25.i18.2162. World J Gastroenterol. 2019. PMID: 31143068 Free PMC article. Review.
Extra-articular manifestations, like uveitis, psoriasis and inflammatory bowel disease (IBD) are frequently observed in the setting of SpA and are, in fact, part of the SpA classification criteria. ...Various therapeutic modalities are available with monoclon …
Extra-articular manifestations, like uveitis, psoriasis and inflammatory bowel disease (IBD) are frequently observed in …
Somatic inflammatory gene mutations in human ulcerative colitis epithelium.
Nanki K, Fujii M, Shimokawa M, Matano M, Nishikori S, Date S, Takano A, Toshimitsu K, Ohta Y, Takahashi S, Sugimoto S, Ishimaru K, Kawasaki K, Nagai Y, Ishii R, Yoshida K, Sasaki N, Hibi T, Ishihara S, Kanai T, Sato T. Nanki K, et al. Nature. 2020 Jan;577(7789):254-259. doi: 10.1038/s41586-019-1844-5. Epub 2019 Dec 18. Nature. 2020. PMID: 31853059
The affected epithelium accumulates somatic mutations in multiple genes that are related to IL-17 signalling-including NFKBIZ, ZC3H12A and PIGR, which are genes that are rarely affected in colon cancer. Targeted sequencing validates the pervasive spread of mutations …
The affected epithelium accumulates somatic mutations in multiple genes that are related to IL-17 signalling-including NFKBIZ, …
Risk for development of inflammatory bowel disease under inhibition of interleukin 17: A systematic review and meta-analysis.
Burisch J, Eigner W, Schreiber S, Aletaha D, Weninger W, Trauner M, Reinisch W, Narula N. Burisch J, et al. PLoS One. 2020 May 27;15(5):e0233781. doi: 10.1371/journal.pone.0233781. eCollection 2020. PLoS One. 2020. PMID: 32459816 Free PMC article.
OBJECTIVE: Cases of inflammatory bowel disease (IBD) during treatment with interleukin (IL)-17 antagonists have been reported from trials in psoriasis, psoriatic arthritis, and ankylosing spondylitis. ...CONCLUSIONS: The risk for developm …
OBJECTIVE: Cases of inflammatory bowel disease (IBD) during treatment with interleukin (IL)-17 ant …
Inflammatory Bowel Disease: Updates on Molecular Targets for Biologics.
Katsanos KH, Papadakis KA. Katsanos KH, et al. Gut Liver. 2017 Jul 15;11(4):455-463. doi: 10.5009/gnl16308. Gut Liver. 2017. PMID: 28486793 Free PMC article. Review.
Therapy for inflammatory bowel disease (IBD) has changed, with several new agents being evaluated. ...The targets of new therapeutic molecules in IBD must aim to restore immune dysregulation by the inhibition of proinflammatory cytokines (TNF-alpha, interl
Therapy for inflammatory bowel disease (IBD) has changed, with several new agents being evaluated. ...The targets of ne …
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