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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 3
2005 1
2006 4
2007 5
2008 12
2009 17
2010 21
2011 27
2012 21
2013 33
2014 36
2015 48
2016 43
2017 45
2018 44
2019 36
2020 52
2021 1
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394 results
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Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis.
Smillie CS, Biton M, Ordovas-Montanes J, Sullivan KM, Burgin G, Graham DB, Herbst RH, Rogel N, Slyper M, Waldman J, Sud M, Andrews E, Velonias G, Haber AL, Jagadeesh K, Vickovic S, Yao J, Stevens C, Dionne D, Nguyen LT, Villani AC, Hofree M, Creasey EA, Huang H, Rozenblatt-Rosen O, Garber JJ, Khalili H, Desch AN, Daly MJ, Ananthakrishnan AN, Shalek AK, Xavier RJ, Regev A. Smillie CS, et al. Cell. 2019 Jul 25;178(3):714-730.e22. doi: 10.1016/j.cell.2019.06.029. Cell. 2019. PMID: 31348891 Free PMC article.
Genome-wide association studies (GWAS) have revealed risk alleles for ulcerative colitis (UC). To understand their cell type specificities and pathways of action, we generate an atlas of 366,650 cells from the colon mucosa of 18 UC patients and 12 healthy individual …
Genome-wide association studies (GWAS) have revealed risk alleles for ulcerative colitis (UC). To understand their cell type s …
Th17 Cells and the IL-23/IL-17 Axis in the Pathogenesis of Periodontitis and Immune-Mediated Inflammatory Diseases.
Bunte K, Beikler T. Bunte K, et al. Int J Mol Sci. 2019 Jul 10;20(14):3394. doi: 10.3390/ijms20143394. Int J Mol Sci. 2019. PMID: 31295952 Free PMC article. Review.
Th1 and Th2 cells of the adaptive immune system are the major players in the pathogenesis of IMIDs. In addition, Th17 cells, their key cytokine IL-17, and IL-23 seem to play pivotal roles. This review aims to provide an overview of the current knowledge about …
Th1 and Th2 cells of the adaptive immune system are the major players in the pathogenesis of IMIDs. In addition, Th17 cells, their key cytok …
Interleukin-17 inhibition: role in psoriasis and inflammatory bowel disease.
Hohenberger M, Cardwell LA, Oussedik E, Feldman SR. Hohenberger M, et al. J Dermatolog Treat. 2018 Feb;29(1):13-18. doi: 10.1080/09546634.2017.1329511. Epub 2017 May 31. J Dermatolog Treat. 2018. PMID: 28521565 Review.
INTRODUCTION: Interleukin 17 (IL-17) antagonism provides a highly effective approach for treating psoriasis. ...RESULTS: IL-17 A inhibition, IL-17RA inhibition and IL-17 knockout led to induction or exacerbation of …
INTRODUCTION: Interleukin 17 (IL-17) antagonism provides a highly effective approach for treating psoriasis. ... …
Novel therapies for immune-mediated inflammatory diseases: What can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn's disease and ulcerative colitis?
Baker KF, Isaacs JD. Baker KF, et al. Ann Rheum Dis. 2018 Feb;77(2):175-187. doi: 10.1136/annrheumdis-2017-211555. Epub 2017 Aug 1. Ann Rheum Dis. 2018. PMID: 28765121 Review.
As well as providing superior treatments for immune-mediated inflammatory diseases (IMIDs), such therapies also offer unrivalled opportunities to study the underlying immunopathological basis of these conditions.In this review, we explore recent approaches to the treatment of IMI …
As well as providing superior treatments for immune-mediated inflammatory diseases (IMIDs), such therapies also offer unrivalled opportuniti …
New treatment options for inflammatory bowel diseases.
Verstockt B, Ferrante M, Vermeire S, Van Assche G. Verstockt B, et al. J Gastroenterol. 2018 May;53(5):585-590. doi: 10.1007/s00535-018-1449-z. Epub 2018 Mar 19. J Gastroenterol. 2018. PMID: 29556726 Free PMC article. Review.
Also, more selective anti-IL23 agents (anti-p19) have shown efficacy and are being further developed, in contrast to agents inhibiting IL-17 downstream which have failed in clinical trials despite their clear efficacy in psoriasis (Verstockt et al. in Expert Opin Bi …
Also, more selective anti-IL23 agents (anti-p19) have shown efficacy and are being further developed, in contrast to agents inhibiting IL
Systemic Treatment of Psoriasis with JAK Inhibitors: A Review.
Kvist-Hansen A, Hansen PR, Skov L. Kvist-Hansen A, et al. Dermatol Ther (Heidelb). 2020 Feb;10(1):29-42. doi: 10.1007/s13555-019-00347-w. Epub 2019 Dec 31. Dermatol Ther (Heidelb). 2020. PMID: 31893355 Free PMC article. Review.
The inflammatory response is driven by T cells and mediated by multiple cytokines such as tumor necrosis factor and the interleukins IL-17 and IL-23. Moderate-to-severe psoriasis is treated systemically, using either biologics or conventional treatments with …
The inflammatory response is driven by T cells and mediated by multiple cytokines such as tumor necrosis factor and the interleukins IL
Pyoderma gangrenosum: a review of pathogenesis and treatment.
Ahn C, Negus D, Huang W. Ahn C, et al. Expert Rev Clin Immunol. 2018 Mar;14(3):225-233. doi: 10.1080/1744666X.2018.1438269. Epub 2018 Feb 13. Expert Rev Clin Immunol. 2018. PMID: 29406827 Review.
Expert commentary: The presence of abnormal neutrophils and T-cells lead to immune dysregulation, leading to lesions of PG. Increased levels of inflammatory mediators including IL-1beta, IL-8, IL-17, and TNF-alpha contribute to the development of the d …
Expert commentary: The presence of abnormal neutrophils and T-cells lead to immune dysregulation, leading to lesions of PG. Increased levels …
miR-155 targets Est-1 and induces ulcerative colitis via the IL-23/17/6-mediated Th17 pathway.
Hou J, Hu X, Chen B, Chen X, Zhao L, Chen Z, Liu F, Liu Z. Hou J, et al. Pathol Res Pract. 2017 Oct;213(10):1289-1295. doi: 10.1016/j.prp.2017.08.001. Epub 2017 Aug 25. Pathol Res Pract. 2017. PMID: 28888763
IL-17 secreting helper T (Th17) cells have been heavily implicated in tissue-specific immune pathology, including UC. ...In this case, the level of Est-1 decreased even further, thereby enhancing IL-23/17/6-mediated Th17 differentiation. CONCLUSION: mi
IL-17 secreting helper T (Th17) cells have been heavily implicated in tissue-specific immune pathology, including UC. ...In th
TAOK1 negatively regulates IL-17-mediated signaling and inflammation.
Zhang Z, Tang Z, Ma X, Sun K, Fan L, Fang J, Pan J, Wang X, An H, Zhou J. Zhang Z, et al. Cell Mol Immunol. 2018 Aug;15(8):794-802. doi: 10.1038/cmi.2017.158. Epub 2018 Feb 5. Cell Mol Immunol. 2018. PMID: 29400705 Free PMC article.
Interleukin 17 (IL-17) is an important cytokine that can induce tissue inflammation and is involved in the pathogenesis of numerous autoimmune diseases. ...TAOK1 expression is decreased in the colons of ulcerative colitis patients. In con
Interleukin 17 (IL-17) is an important cytokine that can induce tissue inflammation and is involved in the patho
Expression and clinical significance of IL-17 and IL-17 receptor in ulcerative colitis.
Zhang H, Xia B, Li J, Zhao Q, Chen ZT, Zhou R, Wu J. Zhang H, et al. J Huazhong Univ Sci Technolog Med Sci. 2016 Feb;36(1):37-40. doi: 10.1007/s11596-016-1538-2. Epub 2016 Feb 3. J Huazhong Univ Sci Technolog Med Sci. 2016. PMID: 26838737
The purpose of this study was to determine the expression levels of IL-17 in serum and IL-17 receptor (IL-17R) in intestinal mucosa tissue in patients with ulcerative colitis (UC) and controls, and evaluate their relationship with …
The purpose of this study was to determine the expression levels of IL-17 in serum and IL-17 receptor (IL
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