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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1967 1
1974 1
1980 1
1993 1
1994 1
1995 2
1996 8
1997 37
1998 72
1999 136
2000 251
2001 302
2002 372
2003 388
2004 437
2005 489
2006 487
2007 510
2008 523
2009 470
2010 533
2011 590
2012 622
2013 626
2014 666
2015 754
2016 843
2017 876
2018 964
2019 1065
2020 1355
2021 1550
2022 86
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13,406 results
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Page 1
IL-18 and infections: Is there a role for targeted therapies?
Vecchié A, Bonaventura A, Toldo S, Dagna L, Dinarello CA, Abbate A. Vecchié A, et al. J Cell Physiol. 2021 Mar;236(3):1638-1657. doi: 10.1002/jcp.30008. Epub 2020 Aug 13. J Cell Physiol. 2021. PMID: 32794180 Review.
Interleukin (IL)-18 is a pro-inflammatory cytokine belonging to the IL-1 family, first identified for its interferon-gamma-inducing properties. ...IL-18 blockade has become an appealing therapeutic target and has been tested in some IL
Interleukin (IL)-18 is a pro-inflammatory cytokine belonging to the IL-1 family, first identified for its interf
IL-1, IL-18, and IL-33 families of cytokines.
Arend WP, Palmer G, Gabay C. Arend WP, et al. Immunol Rev. 2008 Jun;223:20-38. doi: 10.1111/j.1600-065X.2008.00624.x. Immunol Rev. 2008. PMID: 18613828 Review.
The interleukin-1 (IL-1), IL-18, and IL-33 families of cytokines are related by mechanism of origin, receptor structure, and signal transduction pathways utilized. ...The IL-18 family also contains a specific inhibitor, the IL
The interleukin-1 (IL-1), IL-18, and IL-33 families of cytokines are related by mechanism of origin, rece …
Interleukin-18 in Health and Disease.
Yasuda K, Nakanishi K, Tsutsui H. Yasuda K, et al. Int J Mol Sci. 2019 Feb 2;20(3):649. doi: 10.3390/ijms20030649. Int J Mol Sci. 2019. PMID: 30717382 Free PMC article. Review.
Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-gamma production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naive T cells develop into IL-18
Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-gamma production from anti-CD3-stimulated T
Interleukin 18 (IL-18) as a target for immune intervention.
Wawrocki S, Druszczynska M, Kowalewicz-Kulbat M, Rudnicka W. Wawrocki S, et al. Acta Biochim Pol. 2016;63(1):59-63. doi: 10.18388/abp.2015_1153. Epub 2016 Feb 17. Acta Biochim Pol. 2016. PMID: 26885772 Free article. Review.
Interleukin 18 (IL-18) is a pleiotropic cytokine involved in the regulation of innate and acquired immune response. ...In an organism, bioactivity of the cytokine depends on the intensity of IL-18 production, the level of its natural inhi
Interleukin 18 (IL-18) is a pleiotropic cytokine involved in the regulation of innate and acquired immune respon
Interleukin-18: a regulator of cancer and autoimmune diseases.
Esmailbeig M, Ghaderi A. Esmailbeig M, et al. Eur Cytokine Netw. 2017 Nov 1;28(4):127-140. doi: 10.1684/ecn.2018.0401. Eur Cytokine Netw. 2017. PMID: 29478963 Review.
Interleukin (IL)-18, structurally similar to IL-1beta, is a member of IL-1 superfamily of cytokines. ...IL-18 synergistically with IL-23 can induce IL-17 secretion from Th17 cells. ...
Interleukin (IL)-18, structurally similar to IL-1beta, is a member of IL-1 superfamily of cytokines. ...
Interleukin-18 and diabetic nephropathy: A review.
Yaribeygi H, Atkin SL, Sahebkar A. Yaribeygi H, et al. J Cell Physiol. 2019 May;234(5):5674-5682. doi: 10.1002/jcp.27427. Epub 2018 Nov 11. J Cell Physiol. 2019. PMID: 30417374 Review.
The inflammatory response has an important role in the pathophysiology of diabetic nephropathy that is contributed to by inflammatory mediators such as interleukin-1 (IL-1), IL-6, IL-18, tumor necrosis factor-alpha, and macrophage chemotactic pr …
The inflammatory response has an important role in the pathophysiology of diabetic nephropathy that is contributed to by inflammatory mediat …
Role of IL-18 in transplant biology.
Liu C, Chen J, Liu B, Yuan S, Shou D, Wen L, Wu X, Gong W. Liu C, et al. Eur Cytokine Netw. 2018 Jun 1;29(2):48-51. doi: 10.1684/ecn.2018.0410. Eur Cytokine Netw. 2018. PMID: 30078783 Review.
Neutralizing IL-18 by its inhibitor IL-18 binding protein could efficiently suppress the production of injury-associated cytokines such as IL-6, TNF-alpha, IFN-gamma, CXCL10 (IFN-gamma-inducible protein10), and CX(3)CL1 (fractalkine) and improve …
Neutralizing IL-18 by its inhibitor IL-18 binding protein could efficiently suppress the production of injury-as …
Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18.
Hu B, Ren J, Luo Y, Keith B, Young RM, Scholler J, Zhao Y, June CH. Hu B, et al. Cell Rep. 2017 Sep 26;20(13):3025-3033. doi: 10.1016/j.celrep.2017.09.002. Cell Rep. 2017. PMID: 28954221 Free PMC article.
Robust enhancement of proliferation of IL-18-secreting human T cells occurred in a xenograft model, and this was dependent on TCR and IL-18R signaling. IL-18 augmented IFN-gamma secretion and proliferation of T cells activated by the endogenous …
Robust enhancement of proliferation of IL-18-secreting human T cells occurred in a xenograft model, and this was dependent on …
IL-18 and Cutaneous Inflammatory Diseases.
Lee JH, Cho DH, Park HJ. Lee JH, et al. Int J Mol Sci. 2015 Dec 9;16(12):29357-69. doi: 10.3390/ijms161226172. Int J Mol Sci. 2015. PMID: 26690141 Free PMC article. Review.
Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. ...Previous studies have implicated IL-18 in the pathogenesis of various diseases. However, it is not well understood biologic activities of IL-18
Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. ...Previous studies have implic
Associations of polymorphisms in IL-6 and IL-18 with tuberculosis: Evidence from a meta-analysis.
He C, Liu L. He C, et al. Microb Pathog. 2020 Feb;139:103823. doi: 10.1016/j.micpath.2019.103823. Epub 2019 Oct 30. Microb Pathog. 2020. PMID: 31676365 Free article.
BACKGROUND: Associations between polymorphisms in interleukin-6 (IL-6)/interleukin-18 (IL-18) and tuberculosis (TB) were already reported by many publications. The aim of this meta-analysis was to better clarify associations between polym …
BACKGROUND: Associations between polymorphisms in interleukin-6 (IL-6)/interleukin-18 (IL-18) and …
13,406 results
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