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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 1
2000 1
2001 16
2002 72
2003 97
2004 125
2005 161
2006 222
2007 303
2008 418
2009 471
2010 498
2011 560
2012 599
2013 618
2014 605
2015 671
2016 633
2017 607
2018 667
2019 692
2020 580
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7,599 results
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Page 1
The IL-23-IL-17 pathway as a therapeutic target in axial spondyloarthritis.
Sieper J, Poddubnyy D, Miossec P. Sieper J, et al. Nat Rev Rheumatol. 2019 Dec;15(12):747-757. doi: 10.1038/s41584-019-0294-7. Epub 2019 Sep 24. Nat Rev Rheumatol. 2019. PMID: 31551538 Review.
The cytokines IL-23 and IL-17 have an important role in the pathogenesis of, and as a therapeutic target in, both animal models of chronic inflammation and some human chronic inflammatory diseases. The traditional view is that a main source of IL-17 is …
The cytokines IL-23 and IL-17 have an important role in the pathogenesis of, and as a therapeutic target in, both anima …
Discovery of the IL-23/IL-17 Signaling Pathway and the Treatment of Psoriasis.
Hawkes JE, Yan BY, Chan TC, Krueger JG. Hawkes JE, et al. J Immunol. 2018 Sep 15;201(6):1605-1613. doi: 10.4049/jimmunol.1800013. J Immunol. 2018. PMID: 30181299 Free PMC article. Review.
Under the regulation of IL-23, T cells that produce high levels of IL-17 create a self-amplifying, feed-forward inflammatory response in keratinocytes that drives the development of thickened skin lesions infiltrated with a mixture of inflammatory cell popula …
Under the regulation of IL-23, T cells that produce high levels of IL-17 create a self-amplifying, feed-forward inflamm …
Effects of the IL-23-IL-17 pathway on bone in spondyloarthritis.
Gravallese EM, Schett G. Gravallese EM, et al. Nat Rev Rheumatol. 2018 Nov;14(11):631-640. doi: 10.1038/s41584-018-0091-8. Nat Rev Rheumatol. 2018. PMID: 30266977 Review.
Over the past several years, a pathophysiological role for the IL-23-IL-17 pathway in human disease has been defined. A subset of rheumatic diseases, including psoriatic arthritis (PsA) and ankylosing spondylitis (AS), are now acknowledged to be triggered by …
Over the past several years, a pathophysiological role for the IL-23-IL-17 pathway in human disease has been defined. A …
Interleukin (IL)-12 and IL-23 and Their Conflicting Roles in Cancer.
Yan J, Smyth MJ, Teng MWL. Yan J, et al. Cold Spring Harb Perspect Biol. 2018 Jul 2;10(7):a028530. doi: 10.1101/cshperspect.a028530. Cold Spring Harb Perspect Biol. 2018. PMID: 28716888 Free PMC article. Review.
The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the development of antitumor or protumor immunity. In this review, we discuss the role IL-12 and IL-23 plays in tumor biology from p …
The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the developme …
IL-12, IL-23 and IL-17 in IBD: immunobiology and therapeutic targeting.
Moschen AR, Tilg H, Raine T. Moschen AR, et al. Nat Rev Gastroenterol Hepatol. 2019 Mar;16(3):185-196. doi: 10.1038/s41575-018-0084-8. Nat Rev Gastroenterol Hepatol. 2019. PMID: 30478416 Review.
IL-12 and IL-23 are closely related cytokines with important roles in the regulation of tissue inflammation. Converging evidence from studies in mice, human observational studies and population genetics supports the importance of these cytokines in the regula
IL-12 and IL-23 are closely related cytokines with important roles in the regulation of tissue inflammation. Converging
IL-23 secreted by myeloid cells drives castration-resistant prostate cancer.
Calcinotto A, Spataro C, Zagato E, Di Mitri D, Gil V, Crespo M, De Bernardis G, Losa M, Mirenda M, Pasquini E, Rinaldi A, Sumanasuriya S, Lambros MB, Neeb A, Lucianò R, Bravi CA, Nava-Rodrigues D, Dolling D, Prayer-Galetti T, Ferreira A, Briganti A, Esposito A, Barry S, Yuan W, Sharp A, de Bono J, Alimonti A. Calcinotto A, et al. Nature. 2018 Jul;559(7714):363-369. doi: 10.1038/s41586-018-0266-0. Epub 2018 Jun 27. Nature. 2018. PMID: 29950727 Free PMC article.
Here we identify IL-23 produced by myeloid-derived suppressor cells (MDSCs) as a driver of CRPC in mice and patients with CRPC. ...Intra-tumour MDSC infiltration and IL-23 concentration are increased in blood and tumour samples from patients with CRPC. …
Here we identify IL-23 produced by myeloid-derived suppressor cells (MDSCs) as a driver of CRPC in mice and patients with CRPC …
IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases.
Teng MW, Bowman EP, McElwee JJ, Smyth MJ, Casanova JL, Cooper AM, Cua DJ. Teng MW, et al. Nat Med. 2015 Jul;21(7):719-29. doi: 10.1038/nm.3895. Epub 2015 Jun 29. Nat Med. 2015. PMID: 26121196 Review.
The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell-mediated responses in inflammation for more than a decade after it was first identified. Discovery of the cytokine IL-23, which shares a common p40 subunit with IL- …
The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell-mediated responses in inflammation for more t …
The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing.
Gaffen SL, Jain R, Garg AV, Cua DJ. Gaffen SL, et al. Nat Rev Immunol. 2014 Sep;14(9):585-600. doi: 10.1038/nri3707. Nat Rev Immunol. 2014. PMID: 25145755 Free PMC article. Review.
In this Review, we focus on the recent advances that have been made regarding the transcriptional control of TH17 cell plasticity and stability, as well as the effector functions of TH17 cells, and we highlight the mechanisms of IL-17 signalling in mesenchymal and barrier …
In this Review, we focus on the recent advances that have been made regarding the transcriptional control of TH17 cell plasticity and stabil …
The IL-23-IL-17 axis in inflammatory arthritis.
Lubberts E. Lubberts E. Nat Rev Rheumatol. 2015 Jul;11(7):415-29. doi: 10.1038/nrrheum.2015.53. Epub 2015 Apr 28. Nat Rev Rheumatol. 2015. PMID: 25907700 Review.
The discovery that the IL-23-IL-17 immune pathway is involved in many models of autoimmune disease has changed the concept of the role of T-helper cell subsets in the development of autoimmunity. ...The current view is that innate and adaptive immune cells ex …
The discovery that the IL-23-IL-17 immune pathway is involved in many models of autoimmune disease has changed the conc …
Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis.
van der Fits L, Mourits S, Voerman JS, Kant M, Boon L, Laman JD, Cornelissen F, Mus AM, Florencia E, Prens EP, Lubberts E. van der Fits L, et al. J Immunol. 2009 May 1;182(9):5836-45. doi: 10.4049/jimmunol.0802999. J Immunol. 2009. PMID: 19380832 Free article.
Recently, a crucial role was proposed for the IL-23/IL-17 axis in psoriasis. We hypothesized that IMQ-induced dermatitis in mice can serve as a model for the analysis of pathogenic mechanisms in psoriasis-like dermatitis and assessed its IL-23/ …
Recently, a crucial role was proposed for the IL-23/IL-17 axis in psoriasis. We hypothesized that IMQ-induced dermatiti …
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