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2007 4
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2010 6
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2016 12
2017 5
2018 9
2019 3
2020 5
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IL-23 in inflammatory bowel diseases and colon cancer.
Neurath MF. Neurath MF. Cytokine Growth Factor Rev. 2019 Feb;45:1-8. doi: 10.1016/j.cytogfr.2018.12.002. Epub 2018 Dec 12. Cytokine Growth Factor Rev. 2019. PMID: 30563755 Review.
Studies in recent years have identified a pivotal role of the cytokine IL-23 in the pathogenesis of inflammatory bowel diseases (IBD: Crohn´s disease, ulcerative colitis) and colitis-associated colon cancer. Genetic studies revealed that subgrou …
Studies in recent years have identified a pivotal role of the cytokine IL-23 in the pathogenesis of inflammatory bowel
Interleukin-17-producing γδ T (γδ17) cells in inflammatory diseases.
Akitsu A, Iwakura Y. Akitsu A, et al. Immunology. 2018 Dec;155(4):418-426. doi: 10.1111/imm.12993. Epub 2018 Sep 10. Immunology. 2018. PMID: 30133701 Free PMC article. Review.
Interleukin-17 (IL-17) is a pro-inflammatory cytokine and is involved in the development of many diseases. Recent studies have revealed that IL-17-producing γδ T cells (γδ17 cells) in addition to IL-17-producing CD4(+) T cells [T helper type 17 …
Interleukin-17 (IL-17) is a pro-inflammatory cytokine and is involved in the development of many diseases. Recent studi …
Interleukin-23: a key cytokine in inflammatory diseases.
Duvallet E, Semerano L, Assier E, Falgarone G, Boissier MC. Duvallet E, et al. Ann Med. 2011 Nov;43(7):503-11. doi: 10.3109/07853890.2011.577093. Epub 2011 May 17. Ann Med. 2011. PMID: 21585245 Review.
Activated Th17 cells produce IL-17A, IL-17F, IL-6, IL-22, TNF-α, and GM-CSF. Inflammatory macrophages express IL-23R and are activated by IL-23 to produce IL-1, TNF-α, and IL-23 itself. ...IL-23 is found …
Activated Th17 cells produce IL-17A, IL-17F, IL-6, IL-22, TNF-α, and GM-CSF. Inflammatory macrophages exp …
Genetics of inflammatory bowel disease in Asia: systematic review and meta-analysis.
Ng SC, Tsoi KK, Kamm MA, Xia B, Wu J, Chan FK, Sung JJ. Ng SC, et al. Inflamm Bowel Dis. 2012 Jun;18(6):1164-76. doi: 10.1002/ibd.21845. Epub 2011 Sep 1. Inflamm Bowel Dis. 2012. PMID: 21887729 Review.
BACKGROUND: Inflammatory bowel diseases (IBD) result from an interaction between genetic and environmental factors. Preliminary findings suggest that susceptibility genes differ between IBD patients in Asia and the West. ...Interleukin (IL)-23R
BACKGROUND: Inflammatory bowel diseases (IBD) result from an interaction between genetic and environmental factors. Pre …
Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.
Buonocore S, Ahern PP, Uhlig HH, Ivanov II, Littman DR, Maloy KJ, Powrie F. Buonocore S, et al. Nature. 2010 Apr 29;464(7293):1371-5. doi: 10.1038/nature08949. Nature. 2010. PMID: 20393462 Free PMC article.
The key role of interleukin (IL)-23 in the pathogenesis of autoimmune and chronic inflammatory disorders is supported by the identification of IL-23 receptor (IL-23R) susceptibility alleles associated with inflammatory bowel dis
The key role of interleukin (IL)-23 in the pathogenesis of autoimmune and chronic inflammatory disorders is supported by the i …
Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12Rβ1.
Bloch Y, Bouchareychas L, Merceron R, Składanowska K, Van den Bossche L, Detry S, Govindarajan S, Elewaut D, Haerynck F, Dullaers M, Adamopoulos IE, Savvides SN. Bloch Y, et al. Immunity. 2018 Jan 16;48(1):45-58.e6. doi: 10.1016/j.immuni.2017.12.008. Epub 2017 Dec 26. Immunity. 2018. PMID: 29287995 Free PMC article.
Interleukin-23 (IL-23), an IL-12 family cytokine, plays pivotal roles in pro-inflammatory T helper 17 cell responses linked to autoimmune and inflammatory diseases. ...We determined a crystal structure of human IL-23 in complex with its c …
Interleukin-23 (IL-23), an IL-12 family cytokine, plays pivotal roles in pro-inflammatory T helper 17 cell responses li …
mTOR Mediates IL-23 Induction of Neutrophil IL-17 and IL-22 Production.
Chen F, Cao A, Yao S, Evans-Marin HL, Liu H, Wu W, Carlsen ED, Dann SM, Soong L, Sun J, Zhao Q, Cong Y. Chen F, et al. J Immunol. 2016 May 15;196(10):4390-9. doi: 10.4049/jimmunol.1501541. Epub 2016 Apr 11. J Immunol. 2016. PMID: 27067005 Free PMC article.
It has been shown recently that neutrophils are able to produce IL-22 and IL-17, which differentially regulate the pathogenesis of inflammatory bowel disease. However, it is still largely unknown how the neutrophil production of IL-22 and …
It has been shown recently that neutrophils are able to produce IL-22 and IL-17, which differentially regulate the pathogenesi …
Expression of IL-23R and IL-17 and the pathology and prognosis of urinary bladder carcinoma.
Liu J, Wang L, Wang T, Wang J. Liu J, et al. Oncol Lett. 2018 Oct;16(4):4325-4330. doi: 10.3892/ol.2018.9145. Epub 2018 Jul 13. Oncol Lett. 2018. PMID: 30214568 Free PMC article.
IL-23/IL-17 axis significantly inhibited the development of inflammatory bowel disease. Thirty patients with UBC were enrolled in Zhengzhou Central Hospital Affiliated to Zhengzhou University from September 2013 to September 2014. ...Overall sur
IL-23/IL-17 axis significantly inhibited the development of inflammatory bowel disease. Thirty patients w
Induced and spontaneous colitis mouse models reveal complex interactions between IL-10 and IL-12/IL-23 pathways.
Hurtubise R, Audiger C, Dominguez-Punaro MC, Chabot-Roy G, Chognard G, Raymond-Marchand L, Coderre L, Chemtob S, Michnick SW, Rioux JD, Lesage S. Hurtubise R, et al. Cytokine. 2019 Sep;121:154738. doi: 10.1016/j.cyto.2019.154738. Epub 2019 May 31. Cytokine. 2019. PMID: 31158699
Crohn's disease (CD) and ulcerative colitis (UC) are the two major forms of inflammatory bowel disease (IBD). These idiopathic and chronic diseases result from inflammation of the gastrointestinal tract and are mainly mediated by the immune syst …
Crohn's disease (CD) and ulcerative colitis (UC) are the two major forms of inflammatory bowel disease (IBD). Th …
Lack of Association between Interleukin 23R (IL-23R) rs10889677 Polymorphism and Inflammatory Bowel Disease Susceptibility In an Iranian Population.
Karimkhani S, Chaleshi V, Balaii H, Tarban P, Nourian M, Irani S, Shahrokh S, Asadzadeh Aghdaei H, Mohammad Alizadeh AH, Norouzinia M, Zali MR. Karimkhani S, et al. Rep Biochem Mol Biol. 2018 Oct;7(1):16-22. Rep Biochem Mol Biol. 2018. PMID: 30324113 Free PMC article.
BACKGROUND: Inflammatory bowel diseases (IBDs), which include ulcerative colitis (UC) and Crohn's disease (CD), are inflammatory disorders that affect the gastrointestinal tract. A combination of inflammatory cytokines has an important ro …
BACKGROUND: Inflammatory bowel diseases (IBDs), which include ulcerative colitis (UC) and Crohn's disease (CD), …
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