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2007 1
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2009 7
2010 7
2011 5
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2015 3
2016 4
2017 7
2018 5
2019 4
2020 7
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Human IL-23R Cytokine-Binding Homology Region-Fc Fusion Protein Ameliorates Psoriasis via the Decrease of Systemic Th17 and ILC3 Cell Responses.
Gao Y, Bian Z, Xue W, Li Q, Zeng Y, Wang Y, Tang L, Tang T, Gao X, Guo W. Gao Y, et al. Int J Mol Sci. 2019 Aug 26;20(17):4170. doi: 10.3390/ijms20174170. Int J Mol Sci. 2019. PMID: 31454926 Free PMC article.
Interleukin (IL)-23 is considered an effective therapeutic target for the treatment of psoriasis because of the crucial role of the IL-23/IL-17 axis in the pathogenesis of psoriasis, and it has recently been reported to be involved in ILC3 cell …
Interleukin (IL)-23 is considered an effective therapeutic target for the treatment of psoriasis because of the crucial role o …
Evaluation of interleukin-23 receptor (IL-23R) gene polymorphisms and serum IL-23 levels in patients with psoriasis.
Filiz B, Yıldırım M, Hekimler Öztürk K, Şirin FB, Çelik S, Erturan İ, Korkmaz S, Orhan H. Filiz B, et al. Turk J Med Sci. 2019 Oct 24;49(5):1386-1394. doi: 10.3906/sag-1904-48. Turk J Med Sci. 2019. PMID: 31648514 Free PMC article.
BACKGROUND/AIM: IL-23R gene polymorphisms and the association of these polymorphisms with serum IL-23 levels were investigated in patients with psoriasis in the current study. ...CONCLUSION: IL-23R gene polymorphisms including rs2201841, …
BACKGROUND/AIM: IL-23R gene polymorphisms and the association of these polymorphisms with serum IL-23 levels were inves …
Pathophysiology and inhibition of IL-23 signaling in psoriatic arthritis: A molecular insight.
Nguyen CT, Bloch Y, Składanowska K, Savvides SN, Adamopoulos IE. Nguyen CT, et al. Clin Immunol. 2019 Sep;206:15-22. doi: 10.1016/j.clim.2018.09.002. Epub 2018 Sep 6. Clin Immunol. 2019. PMID: 30196070 Free PMC article. Review.
A role of the interleukin-23 (IL-23)/IL-23R (IL-23 receptor) interaction in the development of psoriasis and PsA is well established. ...In this review, we will discuss recent advances on the cellular and molecular pathophysiological mechanisms …
A role of the interleukin-23 (IL-23)/IL-23R (IL-23 receptor) interaction in the development of psoriasis
Interleukin-17-producing γδ T (γδ17) cells in inflammatory diseases.
Akitsu A, Iwakura Y. Akitsu A, et al. Immunology. 2018 Dec;155(4):418-426. doi: 10.1111/imm.12993. Epub 2018 Sep 10. Immunology. 2018. PMID: 30133701 Free PMC article. Review.
Interleukin-17 (IL-17) is a pro-inflammatory cytokine and is involved in the development of many diseases. Recent studies have revealed that IL-17-producing γδ T cells (γδ17 cells) in addition to IL-17-producing CD4(+) T cells [T helper type 17 (Th17) cells] …
Interleukin-17 (IL-17) is a pro-inflammatory cytokine and is involved in the development of many diseases. Recent studies have reveal …
Interleukin-23: a key cytokine in inflammatory diseases.
Duvallet E, Semerano L, Assier E, Falgarone G, Boissier MC. Duvallet E, et al. Ann Med. 2011 Nov;43(7):503-11. doi: 10.3109/07853890.2011.577093. Epub 2011 May 17. Ann Med. 2011. PMID: 21585245 Review.
Activated Th17 cells produce IL-17A, IL-17F, IL-6, IL-22, TNF-α, and GM-CSF. Inflammatory macrophages express IL-23R and are activated by IL-23 to produce IL-1, TNF-α, and IL-23 itself. ...Ustekinumab, which inhibits …
Activated Th17 cells produce IL-17A, IL-17F, IL-6, IL-22, TNF-α, and GM-CSF. Inflammatory macrophages express …
Investigation of association of the IL-12B and IL-23R genetic variations with psoriatic risk in a South Indian Tamil cohort.
Indhumathi S, Rajappa M, Chandrashekar L, Ananthanarayanan PH, Thappa DM, Negi VS. Indhumathi S, et al. Hum Immunol. 2016 Jan;77(1):54-62. doi: 10.1016/j.humimm.2015.10.006. Epub 2015 Oct 20. Hum Immunol. 2016. PMID: 26472011
RESULTS: We observed that the patients carrying the risk genotypes of IL-12B (rs3212227) and IL-23R (rs2201841) conferred an increased susceptibility to psoriasis. ...CONCLUSION: Our results suggest that IL-12B (rs3212227) and IL-23R
RESULTS: We observed that the patients carrying the risk genotypes of IL-12B (rs3212227) and IL-23R (rs2201841) conferr …
Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation.
Cai Y, Shen X, Ding C, Qi C, Li K, Li X, Jala VR, Zhang HG, Wang T, Zheng J, Yan J. Cai Y, et al. Immunity. 2011 Oct 28;35(4):596-610. doi: 10.1016/j.immuni.2011.08.001. Epub 2011 Oct 6. Immunity. 2011. PMID: 21982596 Free PMC article.
Dermal γδ T cells constitutively expressed the IL-23 receptor (IL-23R) and transcriptional factor RORγt. IL-17 production from dermal γδ T cells was independent of αβ T cells. ...Thus, IL-23-responsive dermal γδ T cells are the major IL-1 …
Dermal γδ T cells constitutively expressed the IL-23 receptor (IL-23R) and transcriptional factor RORγt. IL-17 p …
Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.
Buonocore S, Ahern PP, Uhlig HH, Ivanov II, Littman DR, Maloy KJ, Powrie F. Buonocore S, et al. Nature. 2010 Apr 29;464(7293):1371-5. doi: 10.1038/nature08949. Nature. 2010. PMID: 20393462 Free PMC article.
The key role of interleukin (IL)-23 in the pathogenesis of autoimmune and chronic inflammatory disorders is supported by the identification of IL-23 receptor (IL-23R) susceptibility alleles associated with inflammatory bowel disease, psoriasis a …
The key role of interleukin (IL)-23 in the pathogenesis of autoimmune and chronic inflammatory disorders is supported by the identifi …
Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12Rβ1.
Bloch Y, Bouchareychas L, Merceron R, Składanowska K, Van den Bossche L, Detry S, Govindarajan S, Elewaut D, Haerynck F, Dullaers M, Adamopoulos IE, Savvides SN. Bloch Y, et al. Immunity. 2018 Jan 16;48(1):45-58.e6. doi: 10.1016/j.immuni.2017.12.008. Epub 2017 Dec 26. Immunity. 2018. PMID: 29287995 Free PMC article.
We determined a crystal structure of human IL-23 in complex with its cognate receptor, IL-23R, and revealed that IL-23R bound to IL-23 exclusively via its N-terminal immunoglobulin domain. The structural and functional hotspot of this int …
We determined a crystal structure of human IL-23 in complex with its cognate receptor, IL-23R, and revealed that IL
IL-15 and IL-23 synergize to trigger Th17 response by CLA(+) T cells in psoriasis.
de Jesús-Gil C, Ruiz-Romeu E, Ferran M, Sagristà M, Chiriac A, García P, Celada A, Pujol RM, Santamaria-Babí LF. de Jesús-Gil C, et al. Exp Dermatol. 2020 May 31. doi: 10.1111/exd.14113. Online ahead of print. Exp Dermatol. 2020. PMID: 32476200
IL-15 has emerged as a potentially relevant target in the IL-17 response in psoriasis. However, its mechanism is poorly characterized in humans. IL-15 and IL-23 are constitutively expressed in the psoriatic lesion. Also, IL-15 is consider
IL-15 has emerged as a potentially relevant target in the IL-17 response in psoriasis. However, its mechanism is poorly
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