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2008 2
2009 4
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2011 3
2012 3
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2015 1
2016 1
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2018 2
2019 4
2020 2
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Pathophysiology and inhibition of IL-23 signaling in psoriatic arthritis: A molecular insight.
Nguyen CT, Bloch Y, Składanowska K, Savvides SN, Adamopoulos IE. Nguyen CT, et al. Clin Immunol. 2019 Sep;206:15-22. doi: 10.1016/j.clim.2018.09.002. Epub 2018 Sep 6. Clin Immunol. 2019. PMID: 30196070 Free PMC article. Review.
Psoriatic arthritis (PsA) is a chronic inflammatory arthritis of unknown etiology, and currently the cellular and molecular interactions that dictate its pathogenesis remain elusive. A role of the interleukin-23 (IL-23)/IL-23R (IL-
Psoriatic arthritis (PsA) is a chronic inflammatory arthritis of unknown etiology, and currently the cellular and molec
Interleukin-17-producing γδ T (γδ17) cells in inflammatory diseases.
Akitsu A, Iwakura Y. Akitsu A, et al. Immunology. 2018 Dec;155(4):418-426. doi: 10.1111/imm.12993. Epub 2018 Sep 10. Immunology. 2018. PMID: 30133701 Free PMC article. Review.
Interleukin-17 (IL-17) is a pro-inflammatory cytokine and is involved in the development of many diseases. Recent studies have revealed that IL-17-producing γδ T cells (γδ17 cells) in addition to IL-17-producing CD4(+) T cells [T helper type 17 (Th17) cells] …
Interleukin-17 (IL-17) is a pro-inflammatory cytokine and is involved in the development of many diseases. Recent studies have reveal …
IL-23R gene polymorphism rs2201841 is associated with psoriatic arthritis.
Popadic S, Ramic Z, Medenica Lj, Pravica V, Popadic D. Popadic S, et al. Int J Immunogenet. 2014 Aug;41(4):335-7. doi: 10.1111/iji.12127. Epub 2014 Jun 9. Int J Immunogenet. 2014. PMID: 24910145
We examined rs2201841 within IL-23R gene in Serbian patients with psoriasis and healthy controls. G allele frequency was significantly increased in the group of patients with psoriatic arthritis compared with controls (0.481 vs 0.308). Carriage of G al …
We examined rs2201841 within IL-23R gene in Serbian patients with psoriasis and healthy controls. G allele frequency was signi …
Evidence that tissue resident human enthesis γδT-cells can produce IL-17A independently of IL-23R transcript expression.
Cuthbert RJ, Watad A, Fragkakis EM, Dunsmuir R, Loughenbury P, Khan A, Millner PA, Davison A, Marzo-Ortega H, Newton D, Bridgewood C, McGonagle DG. Cuthbert RJ, et al. Ann Rheum Dis. 2019 Nov;78(11):1559-1565. doi: 10.1136/annrheumdis-2019-215210. Epub 2019 Sep 17. Ann Rheum Dis. 2019. PMID: 31530557 Free PMC article.
Entheseal Vδ2 cells expressed high relative abundance of IL-23/17-associated transcripts including IL-23R, RORC and CCR6, whereas the Vδ1 subset almost completely lacked detectable IL-23R transcript. ...CONCLUSION: Spinal entheseal Vδ1 and Vδ2 s …
Entheseal Vδ2 cells expressed high relative abundance of IL-23/17-associated transcripts including IL-23R, RORC and CCR …
Interleukin (IL)-9/IL-9R axis drives γδ T cells activation in psoriatic arthritis patients.
Guggino G, Ciccia F, Di Liberto D, Lo Pizzo M, Ruscitti P, Cipriani P, Ferrante A, Sireci G, Dieli F, Fourniè JJ, Giacomelli R, Triolo G. Guggino G, et al. Clin Exp Immunol. 2016 Dec;186(3):277-283. doi: 10.1111/cei.12853. Epub 2016 Oct 21. Clin Exp Immunol. 2016. PMID: 27543964 Free PMC article.
Cytokines such as tumour necrosis factor (TNF)-α, interleukin (IL)-12, interferon (IFN)-γ, IL-23 and, more recently, IL-9, have been implicated in the initiation/maintenance of inflammation in psoriasis and psoriatic arthritis (PsA). ...Moreover …
Cytokines such as tumour necrosis factor (TNF)-α, interleukin (IL)-12, interferon (IFN)-γ, IL-23 and, more recently, IL
Th17 and Th22 cells in psoriatic arthritis and psoriasis.
Benham H, Norris P, Goodall J, Wechalekar MD, FitzGerald O, Szentpetery A, Smith M, Thomas R, Gaston H. Benham H, et al. Arthritis Res Ther. 2013 Sep 26;15(5):R136. doi: 10.1186/ar4317. Arthritis Res Ther. 2013. PMID: 24286492 Free PMC article.
INTRODUCTION: The aim of this study was to characterize interleukin 17 (IL-17) and interleukin 22 (IL-22) producing cells in peripheral blood (PB), skin, synovial fluid (SF) and synovial tissue (ST) in patients with psoriasis (Ps) and psoriatic arthritis
INTRODUCTION: The aim of this study was to characterize interleukin 17 (IL-17) and interleukin 22 (IL-22) producing cells in p …
Interleukin-23: a key cytokine in inflammatory diseases.
Duvallet E, Semerano L, Assier E, Falgarone G, Boissier MC. Duvallet E, et al. Ann Med. 2011 Nov;43(7):503-11. doi: 10.3109/07853890.2011.577093. Epub 2011 May 17. Ann Med. 2011. PMID: 21585245 Review.
Activated Th17 cells produce IL-17A, IL-17F, IL-6, IL-22, TNF-α, and GM-CSF. Inflammatory macrophages express IL-23R and are activated by IL-23 to produce IL-1, TNF-α, and IL-23 itself. ...Ustekinumab, which inhibits …
Activated Th17 cells produce IL-17A, IL-17F, IL-6, IL-22, TNF-α, and GM-CSF. Inflammatory macrophages express …
IL-23A, IL-23R, IL-17A and IL-17R polymorphisms in different psoriatic arthritis clinical manifestations in the northern Italian population.
Catanoso MG, Boiardi L, Macchioni P, Garagnani P, Sazzini M, De Fanti S, Farnetti E, Casali B, Chiarolanza I, Nicoli D, Luiselli D, Salvarani C. Catanoso MG, et al. Rheumatol Int. 2013 May;33(5):1165-76. doi: 10.1007/s00296-012-2501-6. Epub 2012 Sep 7. Rheumatol Int. 2013. PMID: 22955875
To investigate the genetic variability of IL-17A, IL17-RA, IL-23A and IL-23R genes on an in-depth phenotypically characterized northern Italian Psoriatic arthritis (PsA) case-control cohort, in search for associations specific to differen …
To investigate the genetic variability of IL-17A, IL17-RA, IL-23A and IL-23R genes on an in-depth phenotypically …
Functional significance of MAIT cells in psoriatic arthritis.
Raychaudhuri SK, Abria C, Mitra A, Raychaudhuri SP. Raychaudhuri SK, et al. Cytokine. 2020 Jan;125:154855. doi: 10.1016/j.cyto.2019.154855. Epub 2019 Sep 18. Cytokine. 2020. PMID: 31541902
Tc17 CD8+/MAIT cells likely to have a critical role in psoriatic arthritis (PsA). Herein, we have explored pathological significance of MAIT cell in PsA. ...This IL-23R was functionally active as evidenced by profound mitotic effect in presence of rIL- …
Tc17 CD8+/MAIT cells likely to have a critical role in psoriatic arthritis (PsA). Herein, we have explored pathological signif …
Interleukin-23 pathway at the enthesis: The emerging story of enthesitis in spondyloarthropathy.
Bridgewood C, Sharif K, Sherlock J, Watad A, McGonagle D. Bridgewood C, et al. Immunol Rev. 2020 Mar;294(1):27-47. doi: 10.1111/imr.12840. Epub 2020 Jan 19. Immunol Rev. 2020. PMID: 31957051 Review.
The inflammatory disorders collectively termed the seronegative spondyloarthropathies (SpA) include ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis, the arthritis associated with inflammatory bowel disease including Crohn's d …
The inflammatory disorders collectively termed the seronegative spondyloarthropathies (SpA) include ankylosing spondylitis (AS), psoriati
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