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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 1
1957 1
1988 1
2002 3
2003 15
2004 26
2005 26
2006 36
2007 57
2008 70
2009 68
2010 89
2011 103
2012 126
2013 121
2014 131
2015 155
2016 161
2017 132
2018 131
2019 135
2020 120
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1,509 results
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Dual Roles of IL-27 in Cancer Biology and Immunotherapy.
Fabbi M, Carbotti G, Ferrini S. Fabbi M, et al. Mediators Inflamm. 2017;2017:3958069. doi: 10.1155/2017/3958069. Epub 2017 Feb 1. Mediators Inflamm. 2017. PMID: 28255204 Free PMC article. Review.
IL-27 is a pleiotropic two-chain cytokine, composed of EBI3 and IL-27p28 subunits, which is structurally related to both IL-12 and IL-6 cytokine families. IL-27 acts through a heterodimer receptor consisting of IL-27Rα (WSX1
IL-27 is a pleiotropic two-chain cytokine, composed of EBI3 and IL-27p28 subunits, which is structurally related to bot
IL-17, IL-27, and IL-33: A Novel Axis Linked to Immunological Dysfunction During Sepsis.
Morrow KN, Coopersmith CM, Ford ML. Morrow KN, et al. Front Immunol. 2019 Aug 22;10:1982. doi: 10.3389/fimmu.2019.01982. eCollection 2019. Front Immunol. 2019. PMID: 31507598 Free PMC article. Review.
Recent evidence links interleukin (IL)-17, IL-27, and IL-33 to alterations in the immune response during sepsis using patient serum and murine models of peritonitis and pneumonia. ...This review will describe how IL-17, IL-27
Recent evidence links interleukin (IL)-17, IL-27, and IL-33 to alterations in the immune response during …
The immunobiology of interleukin-27.
Yoshida H, Hunter CA. Yoshida H, et al. Annu Rev Immunol. 2015;33:417-43. doi: 10.1146/annurev-immunol-032414-112134. Annu Rev Immunol. 2015. PMID: 25861977 Review.
Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune response. Although it was initially linked with the development of Th1 responses, it is now recognized as a potent antagonist of different classes of inflammation thr
Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune response. Although it was
Regulation and Immune Function of IL-27.
Wang Q, Liu J. Wang Q, et al. Adv Exp Med Biol. 2016;941:191-211. doi: 10.1007/978-94-024-0921-5_9. Adv Exp Med Biol. 2016. PMID: 27734414 Review.
IL-27 is also involved in regulation of immune responses of B cells, NK, DCs, and macrophages. IL-27 production is strictly regulated at both transcriptional and posttranscriptional levels. ...In this chapter, the biological characters of IL-
IL-27 is also involved in regulation of immune responses of B cells, NK, DCs, and macrophages. IL-27 production
IL-27, but not IL-35, inhibits neuroinflammation through modulating GM-CSF expression.
Casella G, Finardi A, Descamps H, Colombo F, Maiorino C, Ruffini F, Patrone M, Degano M, Martino G, Muzio L, Becher B, Furlan R. Casella G, et al. Sci Rep. 2017 Nov 29;7(1):16547. doi: 10.1038/s41598-017-16702-w. Sci Rep. 2017. PMID: 29185463 Free PMC article.
IL-27 and IL-35 are heterodimeric cytokines, members of the IL-12 family and considered to have immunomodulatory properties. ...We demonstrate here that IL-27 holds therapeutic potential during neuroinflammation and that IL-27
IL-27 and IL-35 are heterodimeric cytokines, members of the IL-12 family and considered to have immunomodulatory
IL-27-induced modulation of autoimmunity and its therapeutic potential.
Meka RR, Venkatesha SH, Dudics S, Acharya B, Moudgil KD. Meka RR, et al. Autoimmun Rev. 2015 Dec;14(12):1131-1141. doi: 10.1016/j.autrev.2015.08.001. Epub 2015 Aug 5. Autoimmun Rev. 2015. PMID: 26253381 Free PMC article. Review.
Interleukin-27 (IL-27) is a new member of the IL-12 family. It is produced by activated antigen-presenting cells and plays an important role in the regulation of CD4+ T cell differentiation and immune response. IL-27 activates mult
Interleukin-27 (IL-27) is a new member of the IL-12 family. It is produced by activated antigen-presentin
Increased IL-27/IL-27R expression in association with the immunopathology of murine ocular toxoplasmosis.
Tong X, Chen S, Zheng H, Huang S, Lu F. Tong X, et al. Parasitol Res. 2018 Jul;117(7):2255-2263. doi: 10.1007/s00436-018-5914-7. Epub 2018 May 19. Parasitol Res. 2018. PMID: 29779048
Interleukin 27 (IL-27) is a member of the IL-6/IL-12 family, and IL-27 receptor (IL-27R) consists of WSX-1 (the IL-27Rα subunit) and the signal-transducing subunit gp130. ...Our data suggested that IL-
Interleukin 27 (IL-27) is a member of the IL-6/IL-12 family, and IL-27 receptor (
Interleukin (IL)-6 Inhibits IL-27- and IL-30-Mediated Inflammatory Responses in Human Monocytes.
Petes C, Mariani MK, Yang Y, Grandvaux N, Gee K. Petes C, et al. Front Immunol. 2018 Feb 15;9:256. doi: 10.3389/fimmu.2018.00256. eCollection 2018. Front Immunol. 2018. PMID: 29497424 Free PMC article.
Interleukin (IL)-30, the IL-27p28 subunit of the heterodimeric cytokine IL-27, acts as an antagonist of IL-27 and IL-6 signaling in murine cells via glycoprotein 130 (gp130) receptor and additional binding partners. Thus far
Interleukin (IL)-30, the IL-27p28 subunit of the heterodimeric cytokine IL-27, acts as an antagonist of
Neutrophil polarization by IL-27 as a therapeutic target for intracerebral hemorrhage.
Zhao X, Ting SM, Liu CH, Sun G, Kruzel M, Roy-O'Reilly M, Aronowski J. Zhao X, et al. Nat Commun. 2017 Sep 19;8(1):602. doi: 10.1038/s41467-017-00770-7. Nat Commun. 2017. PMID: 28928459 Free PMC article.
Here, we show that the immunoregulatory cytokine interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhage. ...Here, the authors show interleukin-27 promotes the tissue-protecting functions of neutrophils via, at least par …
Here, we show that the immunoregulatory cytokine interleukin-27 is upregulated centrally and peripherally after intracerebral …
IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm development.
Peshkova IO, Aghayev T, Fatkhullina AR, Makhov P, Titerina EK, Eguchi S, Tan YF, Kossenkov AV, Khoreva MV, Gankovskaya LV, Sykes SM, Koltsova EK. Peshkova IO, et al. Nat Commun. 2019 Nov 6;10(1):5046. doi: 10.1038/s41467-019-13017-4. Nat Commun. 2019. PMID: 31695038 Free PMC article.
Here we report a pathogenic role for the interleukin-27 receptor (IL-27R) in AAA, as genetic ablation of IL-27R protects mice from the disease development. ...IL-27R signaling is required to induce transcriptional programming to overcome HSC qui …
Here we report a pathogenic role for the interleukin-27 receptor (IL-27R) in AAA, as genetic ablation of IL-27R …
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