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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 1
1951 1
1959 2
1963 1
1964 1
1965 1
1966 2
1967 2
1968 1
1972 1
1974 1
1980 1
1981 4
1982 3
1983 10
1984 4
1985 21
1986 15
1987 46
1988 172
1989 451
1990 728
1991 1092
1992 1544
1993 1691
1994 2120
1995 2253
1996 2332
1997 2412
1998 2467
1999 2495
2000 2812
2001 2726
2002 2925
2003 3166
2004 3447
2005 4027
2006 4349
2007 4555
2008 5309
2009 5760
2010 6392
2011 7119
2012 7838
2013 8539
2014 9148
2015 9686
2016 9762
2017 10633
2018 11154
2019 11830
2020 11603
2021 6
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145,872 results
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Page 1
IL-6 in inflammation, immunity, and disease.
Tanaka T, Narazaki M, Kishimoto T. Tanaka T, et al. Cold Spring Harb Perspect Biol. 2014 Sep 4;6(10):a016295. doi: 10.1101/cshperspect.a016295. Cold Spring Harb Perspect Biol. 2014. PMID: 25190079 Free PMC article. Review.
Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions. Although its expression is strictl
Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contribut
IL-6/IL-6 receptor system and its role in physiological and pathological conditions.
Mihara M, Hashizume M, Yoshida H, Suzuki M, Shiina M. Mihara M, et al. Clin Sci (Lond). 2012 Feb;122(4):143-59. doi: 10.1042/CS20110340. Clin Sci (Lond). 2012. PMID: 22029668 Review.
IL (interleukin)-6, which was originally identified as a B-cell differentiation factor, is a multifunctional cytokine that regulates the immune response, haemopoiesis, the acute phase response and inflammation. ...IL-6 exerts its biological acti
IL (interleukin)-6, which was originally identified as a B-cell differentiation factor, is a multifunctional cytokine t
Interleukin (IL-6) Immunotherapy.
Tanaka T, Narazaki M, Kishimoto T. Tanaka T, et al. Cold Spring Harb Perspect Biol. 2018 Aug 1;10(8):a028456. doi: 10.1101/cshperspect.a028456. Cold Spring Harb Perspect Biol. 2018. PMID: 28778870 Free PMC article. Review.
Interleukin 6 (IL-6) is a prototypical cytokine for maintaining homeostasis. When homeostasis is disrupted by infections or tissue injuries, IL-6 is produced immediately and contributes to host defense against such emergent stress through
Interleukin 6 (IL-6) is a prototypical cytokine for maintaining homeostasis. When homeostasis is disrupted by in
IL-6 pathway in the liver: From physiopathology to therapy.
Schmidt-Arras D, Rose-John S. Schmidt-Arras D, et al. J Hepatol. 2016 Jun;64(6):1403-15. doi: 10.1016/j.jhep.2016.02.004. Epub 2016 Feb 8. J Hepatol. 2016. PMID: 26867490 Free article. Review.
Interleukin 6 (IL-6) is a pleiotropic four-helix-bundle cytokine that exerts multiple functions in the body. In the liver, IL-6 is an important inducer of the acute phase response and infection defense. ...On target cells IL-6
Interleukin 6 (IL-6) is a pleiotropic four-helix-bundle cytokine that exerts multiple functions in the body. In
Regulation of IL-6 in Immunity and Diseases.
Tanaka T, Narazaki M, Masuda K, Kishimoto T. Tanaka T, et al. Adv Exp Med Biol. 2016;941:79-88. doi: 10.1007/978-94-024-0921-5_4. Adv Exp Med Biol. 2016. PMID: 27734409 Review.
Interleukin-6 (IL-6) is a prototypical cytokine with functional pleiotropy and plays an important role in host defense. When infections or tissue injuries occur, IL-6 is promptly produced by monocytes and macrophages and contributes to re
Interleukin-6 (IL-6) is a prototypical cytokine with functional pleiotropy and plays an important role in host d
Principles of interleukin (IL)-6-type cytokine signalling and its regulation.
Heinrich PC, Behrmann I, Haan S, Hermanns HM, Müller-Newen G, Schaper F. Heinrich PC, et al. Biochem J. 2003 Aug 15;374(Pt 1):1-20. doi: 10.1042/BJ20030407. Biochem J. 2003. PMID: 12773095 Free PMC article. Review.
The IL (interleukin)-6-type cytokines IL-6, IL-11, LIF (leukaemia inhibitory factor), OSM (oncostatin M), ciliary neurotrophic factor, cardiotrophin-1 and cardiotrophin-like cytokine are an important family of mediators involved in the re …
The IL (interleukin)-6-type cytokines IL-6, IL-11, LIF (leukaemia inhibitory factor), OSM (oncosta …
The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition.
Garbers C, Aparicio-Siegmund S, Rose-John S. Garbers C, et al. Curr Opin Immunol. 2015 Jun;34:75-82. doi: 10.1016/j.coi.2015.02.008. Epub 2015 Mar 6. Curr Opin Immunol. 2015. PMID: 25749511 Review.
Interleukin-6 has long been recognized as a prototypic pro-inflammatory cytokine that is involved in the pathogenesis of all inflammatory diseases. ...In this review, we highlight recent developments in the field of IL-6 research, and specifically focu
Interleukin-6 has long been recognized as a prototypic pro-inflammatory cytokine that is involved in the pathogenesis of all i
Interleukin-6 Family Cytokines.
Rose-John S. Rose-John S. Cold Spring Harb Perspect Biol. 2018 Feb 1;10(2):a028415. doi: 10.1101/cshperspect.a028415. Cold Spring Harb Perspect Biol. 2018. PMID: 28620096 Free PMC article. Review.
The interleukin (IL)-6 family cytokines is a group of cytokines consisting of IL-6, IL-11, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), cardiotrophin 1 (CT-1), cardiotrophin-like cytokine (CLC) …
The interleukin (IL)-6 family cytokines is a group of cytokines consisting of IL-6, IL-11, ciliary …
IL-6: from its discovery to clinical applications.
Kishimoto T. Kishimoto T. Int Immunol. 2010 May;22(5):347-52. doi: 10.1093/intimm/dxq030. Epub 2010 Apr 21. Int Immunol. 2010. PMID: 20410258 Review.
In 1986, we successfully cloned the complementary DNA encoding B-cell stimulatory factor-2, now known as IL-6. At the same time, IFN-beta2 and a 26-kDa protein found in fibroblasts were independently cloned and found to be identical to IL-6. ...Since t …
In 1986, we successfully cloned the complementary DNA encoding B-cell stimulatory factor-2, now known as IL-6. At the same tim …
IL-6 biology: implications for clinical targeting in rheumatic disease.
Calabrese LH, Rose-John S. Calabrese LH, et al. Nat Rev Rheumatol. 2014 Dec;10(12):720-7. doi: 10.1038/nrrheum.2014.127. Epub 2014 Aug 19. Nat Rev Rheumatol. 2014. PMID: 25136784 Review.
Studies have investigated IL-6 biology using cell-bound IL-6 receptors expressed predominantly on hepatocytes and certain haematopoietic cells versus activation mediated by IL-6 and soluble IL-6 receptors via a second protei …
Studies have investigated IL-6 biology using cell-bound IL-6 receptors expressed predominantly on hepatocytes an …
145,872 results
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