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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 3
1991 5
1992 5
1993 5
1994 9
1995 15
1996 11
1997 13
1998 15
1999 11
2000 19
2001 16
2002 22
2003 24
2004 23
2005 43
2006 32
2007 26
2008 47
2009 36
2010 40
2011 51
2012 35
2013 45
2014 55
2015 55
2016 51
2017 55
2018 58
2019 51
2020 54
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851 results
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Randomised trial and open-label extension study of an anti-interleukin-6 antibody in Crohn's disease (ANDANTE I and II).
Danese S, Vermeire S, Hellstern P, Panaccione R, Rogler G, Fraser G, Kohn A, Desreumaux P, Leong RW, Comer GM, Cataldi F, Banerjee A, Maguire MK, Li C, Rath N, Beebe J, Schreiber S. Danese S, et al. Gut. 2019 Jan;68(1):40-48. doi: 10.1136/gutjnl-2017-314562. Epub 2017 Dec 15. Gut. 2019. PMID: 29247068 Free PMC article. Clinical Trial.
OBJECTIVE: Neutralising pro-inflammatory interleukin-6 (IL-6) may effectively treat Crohn's disease (CD). Effects of PF-04236921, an anti-IL-6 antibody, in adults with CD are reported. ...Crohn's Disease Activi …
OBJECTIVE: Neutralising pro-inflammatory interleukin-6 (IL-6) may effectively treat Crohn's disease
IL-6 and Crohn's disease.
Ito H. Ito H. Curr Drug Targets Inflamm Allergy. 2003 Jun;2(2):125-30. doi: 10.2174/1568010033484296. Curr Drug Targets Inflamm Allergy. 2003. PMID: 14561164 Review.
Interleukin-6 (IL-6) is a pleiotropic cytokine with central roles in immune regulation, inflammation, hematopoiesis, and oncogenesis. ...Increased levels of IL-6 and sIL-6R have been demonstrated in both serum and intestinal tissues of th
Interleukin-6 (IL-6) is a pleiotropic cytokine with central roles in immune regulation, inflammation, hematopoie
MCL-1 is modulated in Crohn's disease fibrosis by miR-29b via IL-6 and IL-8.
Nijhuis A, Curciarello R, Mehta S, Feakins R, Bishop CL, Lindsay JO, Silver A. Nijhuis A, et al. Cell Tissue Res. 2017 May;368(2):325-335. doi: 10.1007/s00441-017-2576-1. Epub 2017 Feb 11. Cell Tissue Res. 2017. PMID: 28190086 Free PMC article.
The miR-29 family is involved in fibrosis in multiple organs, including the intestine where miR-29b facilitates TGF-β-mediated up-regulation of collagen in mucosal fibroblasts from Crohn's disease (CD) patients. ...CD fibroblasts treated with IL-6 and …
The miR-29 family is involved in fibrosis in multiple organs, including the intestine where miR-29b facilitates TGF-β-mediated up-regulation …
Novel therapy for Crohn's disease targeting IL-6 signalling.
Ito H. Ito H. Expert Opin Ther Targets. 2004 Aug;8(4):287-94. doi: 10.1517/14728222.8.4.287. Expert Opin Ther Targets. 2004. PMID: 15268624 Review.
The aetiology of Crohn's disease (CD) remains unknown, however, the importance of pro-inflammatory cytokines including IL-6 has been shown. IL-6 can transduce its signal into the cells lacking membrane-bound receptors by forming a complex …
The aetiology of Crohn's disease (CD) remains unknown, however, the importance of pro-inflammatory cytokines including IL
Crohn's Disease Patients with Depression Exhibit Alterations in Monocyte/Macrophage Phenotype and Increased Proinflammatory Cytokine Production.
Tang Y, Zhao L, Lei N, Chen P, Zhang Y. Tang Y, et al. Dig Dis. 2020;38(3):211-221. doi: 10.1159/000501122. Epub 2019 Jun 19. Dig Dis. 2020. PMID: 31216541
The Harvey-Bradshaw index (HBI), the Simple Endoscopic Score for Crohn's disease (SES-CD), and the Global Histological Disease Activity Score (GHAS) were compared between the 2 groups. ...Enzyme-linked Immunosorbent Assay was used to detect plasma levels of M …
The Harvey-Bradshaw index (HBI), the Simple Endoscopic Score for Crohn's disease (SES-CD), and the Global Histological Dise
IL-6, IL-1β, and TNF-α only in combination influence the osteoporotic phenotype in Crohn's patients via bone formation and bone resorption.
Blaschke M, Koepp R, Cortis J, Komrakova M, Schieker M, Hempel U, Siggelkow H. Blaschke M, et al. Adv Clin Exp Med. 2018 Jan;27(1):45-56. doi: 10.17219/acem/67561. Adv Clin Exp Med. 2018. PMID: 29521042 Free article.
In postmenopausal osteoporosis, bone resorption is induced by IL-6, IL-1β and TNF-α. In contrast, in children with CD, IL-6 exclusively decreased bone formation without affecting bone resorption. ...Additional application of dexamethasone to SCP …
In postmenopausal osteoporosis, bone resorption is induced by IL-6, IL-1β and TNF-α. In contrast, in children with CD, …
Il-6 signaling in inflammatory bowel disease: pathophysiological role and clinical relevance.
Mudter J, Neurath MF. Mudter J, et al. Inflamm Bowel Dis. 2007 Aug;13(8):1016-23. doi: 10.1002/ibd.20148. Inflamm Bowel Dis. 2007. PMID: 17476678 Review.
Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBDs) occurring in the gut of genetically susceptible individuals independent of a specific pathogen. ...Thereby, IL-6 induces the transcription factor STAT-3 via
Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBDs) occurring in the gut of geneti
Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation.
Cosin-Roger J, Simmen S, Melhem H, Atrott K, Frey-Wagner I, Hausmann M, de Vallière C, Spalinger MR, Spielmann P, Wenger RH, Zeitz J, Vavricka SR, Rogler G, Ruiz PA. Cosin-Roger J, et al. Nat Commun. 2017 Jul 24;8(1):98. doi: 10.1038/s41467-017-00213-3. Nat Commun. 2017. PMID: 28740109 Free PMC article.
Hypoxia significantly reduces tumor necrosis factor α, interleukin (IL)-6 and NLRP3 expression, and increases the turnover of the autophagy protein p62 in colon biopsies of Crohn's disease patients, and in samples from dextran sulfate sodium-tre …
Hypoxia significantly reduces tumor necrosis factor α, interleukin (IL)-6 and NLRP3 expression, and increases the turno …
Glucocorticoids Impair Phagocytosis and Inflammatory Response Against Crohn's Disease-Associated Adherent-Invasive Escherichia coli.
Olivares-Morales MJ, De La Fuente MK, Dubois-Camacho K, Parada D, Diaz-Jiménez D, Torres-Riquelme A, Xu X, Chamorro-Veloso N, Naves R, Gonzalez MJ, Quera R, Figueroa C, Cidlowski JA, Vidal RM, Hermoso MA. Olivares-Morales MJ, et al. Front Immunol. 2018 May 16;9:1026. doi: 10.3389/fimmu.2018.01026. eCollection 2018. Front Immunol. 2018. PMID: 29867993 Free PMC article.
Crohn's disease (CD) is a chronic inflammatory bowel disorder characterized by deregulated inflammation triggered by environmental factors. ...All bacteria strains induced TNF-α, IL-6, IL-23, CD40, and CD80, which was inhibited by Dex. Thus, our
Crohn's disease (CD) is a chronic inflammatory bowel disorder characterized by deregulated inflammation triggered by environme
Treatment of Crohn's disease with anti-IL-6 receptor antibody.
Ito H. Ito H. J Gastroenterol. 2005 Mar;40 Suppl 16:32-4. doi: 10.1007/BF02990576. J Gastroenterol. 2005. PMID: 15902961 Clinical Trial.
We have demonstrated, by using a T-cell transfer murine colitis model, that blocking interleukin 6 (IL-6) signaling with monoclonal antibody (mAb) to IL-6 receptor (IL-6R) abrogated apoptosis resistance of lamina propria T cells, s …
We have demonstrated, by using a T-cell transfer murine colitis model, that blocking interleukin 6 (IL-6) signal …
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