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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 2
2002 3
2003 4
2004 6
2005 10
2006 16
2007 25
2008 35
2009 46
2010 71
2011 58
2012 58
2013 57
2014 60
2015 56
2016 66
2017 66
2018 58
2019 69
2020 60
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Page 1
Advances and challenges in targeting IRF5, a key regulator of inflammation.
Almuttaqi H, Udalova IA. Almuttaqi H, et al. FEBS J. 2019 May;286(9):1624-1637. doi: 10.1111/febs.14654. Epub 2018 Sep 21. FEBS J. 2019. PMID: 30199605 Free PMC article. Review.
However, studies conducted in different laboratories over the last decade have placed IRF5 as a central regulator of the inflammatory response. ...Given the role of IRF5 in physiology and disease, IRF5 represents a potential therapeutic target. However, despi …
However, studies conducted in different laboratories over the last decade have placed IRF5 as a central regulator of the inflammatory …
Regulating IRFs in IFN Driven Disease.
Jefferies CA. Jefferies CA. Front Immunol. 2019 Mar 29;10:325. doi: 10.3389/fimmu.2019.00325. eCollection 2019. Front Immunol. 2019. PMID: 30984161 Free PMC article. Review.
Three family members, IRF3, IRF5, and IRF7, are critical to production of type I interferons downstream of pathogen recognition receptors that detect viral RNA and DNA. ...In addition, IRF4, IRF8, and IRF5 regulate myeloid cell development and phenotype, thus playin …
Three family members, IRF3, IRF5, and IRF7, are critical to production of type I interferons downstream of pathogen recognition recep …
Microglial IRF5-IRF4 regulatory axis regulates neuroinflammation after cerebral ischemia and impacts stroke outcomes.
Al Mamun A, Chauhan A, Qi S, Ngwa C, Xu Y, Sharmeen R, Hazen AL, Li J, Aronowski JA, McCullough LD, Liu F. Al Mamun A, et al. Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1742-1752. doi: 10.1073/pnas.1914742117. Epub 2019 Dec 31. Proc Natl Acad Sci U S A. 2020. PMID: 31892541 Free PMC article.
In the present study, we genetically modified the IRF5 and IRF4 signaling to explore their roles in stroke. Both in vitro and in vivo assays were utilized; IRF5 or IRF4 small interfering RNA (siRNA), lentivirus, and conditional knockout (CKO) techniques were employe …
In the present study, we genetically modified the IRF5 and IRF4 signaling to explore their roles in stroke. Both in vitro and in vivo …
Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity.
Ban T, Sato GR, Nishiyama A, Akiyama A, Takasuna M, Umehara M, Suzuki S, Ichino M, Matsunaga S, Kimura A, Kimura Y, Yanai H, Miyashita S, Kuromitsu J, Tsukahara K, Yoshimatsu K, Endo I, Yamamoto T, Hirano H, Ryo A, Taniguchi T, Tamura T. Ban T, et al. Immunity. 2016 Aug 16;45(2):319-32. doi: 10.1016/j.immuni.2016.07.015. Epub 2016 Aug 9. Immunity. 2016. PMID: 27521268 Free article.
Here, we found that Lyn physically interacted with IRF5 to inhibit ubiquitination and phosphorylation of IRF5 in the TLR-MyD88 pathway, thereby suppressing the transcriptional activity of IRF5 in a manner independent of Lyn's kinase activity. ...Our results r …
Here, we found that Lyn physically interacted with IRF5 to inhibit ubiquitination and phosphorylation of IRF5 in the TLR-MyD88 …
Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients.
Idborg H, Zandian A, Ossipova E, Wigren E, Preger C, Mobarrez F, Checa A, Sohrabian A, Pucholt P, Sandling JK, Fernandes-Cerqueira C, Rönnelid J, Oke V, Grosso G, Kvarnström M, Larsson A, Wheelock CE, Syvänen AC, Rönnblom L, Kultima K, Persson H, Gräslund S, Gunnarsson I, Nilsson P, Svenungsson E, Jakobsson PJ. Idborg H, et al. Front Immunol. 2019 May 17;10:1029. doi: 10.3389/fimmu.2019.01029. eCollection 2019. Front Immunol. 2019. PMID: 31156624 Free PMC article.
IRF5 was up-regulated while SPDEF was found to be down-regulated in SLE patients. Unsupervised clustering of all investigated proteins identified three molecular subgroups among SLE patients, characterized by (1) high levels of rheumatoid factor-IgM, (2) low IRF5, a
IRF5 was up-regulated while SPDEF was found to be down-regulated in SLE patients. Unsupervised clustering of all investigated protein
KAP1/TRIM28: an inhibitor of IRF5 function in inflammatory macrophages.
Eames HL, Saliba DG, Krausgruber T, Lanfrancotti A, Ryzhakov G, Udalova IA. Eames HL, et al. Immunobiology. 2012 Dec;217(12):1315-24. doi: 10.1016/j.imbio.2012.07.026. Epub 2012 Aug 11. Immunobiology. 2012. PMID: 22995936
To better understand the means of IRF5 transcriptional action, we conducted a screen for IRF5-interacting partners by affinity purification coupled to mass spectrometry and identified KAP1/TRIM28 as a novel protein-protein interaction partner of IRF5. ...We m …
To better understand the means of IRF5 transcriptional action, we conducted a screen for IRF5-interacting partners by affinity …
Different pathways of macrophage activation and polarization.
Juhas U, Ryba-Stanisławowska M, Szargiej P, Myśliwska J. Juhas U, et al. Postepy Hig Med Dosw (Online). 2015 Apr 22;69:496-502. doi: 10.5604/17322693.1150133. Postepy Hig Med Dosw (Online). 2015. PMID: 25983288 Free article. Review.
Mediators of M1 macrophage TLR-dependent polarization include transcription factors such as NF-κB, AP-1, PU.1, CCAAT/enhancer-binding protein α (C/EBP-α), STAT1 as well as interferon regulatory factor 5 (IRF5), while the transcription factors which promote M2 activation in …
Mediators of M1 macrophage TLR-dependent polarization include transcription factors such as NF-κB, AP-1, PU.1, CCAAT/enhancer-binding protei …
Regulation of age-associated B cells by IRF5 in systemic autoimmunity.
Manni M, Gupta S, Ricker E, Chinenov Y, Park SH, Shi M, Pannellini T, Jessberger R, Ivashkiv LB, Pernis AB. Manni M, et al. Nat Immunol. 2018 Apr;19(4):407-419. doi: 10.1038/s41590-018-0056-8. Epub 2018 Feb 26. Nat Immunol. 2018. PMID: 29483597 Free PMC article.
Enhanced ABC formation in SWEF-deficient mice was controlled by the cytokine IL-21 and IRF5, whose variants are strongly associated with lupus. The lack of SWEF proteins led to dysregulated activity of IRF5 in response to stimulation with IL-21. These studies thus e …
Enhanced ABC formation in SWEF-deficient mice was controlled by the cytokine IL-21 and IRF5, whose variants are strongly associated w …
Therapeutic Targeting of IRFs: Pathway-Dependence or Structure-Based?
Thompson CD, Matta B, Barnes BJ. Thompson CD, et al. Front Immunol. 2018 Nov 20;9:2622. doi: 10.3389/fimmu.2018.02622. eCollection 2018. Front Immunol. 2018. PMID: 30515152 Free PMC article. Review.
Here, we will review potential therapeutic strategies for targeting all IRFs by using IRF5 as a candidate targeting molecule....
Here, we will review potential therapeutic strategies for targeting all IRFs by using IRF5 as a candidate targeting molecule....
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