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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 2
1995 1
1999 1
2004 2
2006 2
2007 2
2008 12
2009 25
2010 24
2011 31
2012 31
2013 17
2014 20
2015 16
2016 20
2017 21
2018 25
2019 25
2020 31
2021 2
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278 results
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Emerging views of mitophagy in immunity and autoimmune diseases.
Xu Y, Shen J, Ran Z. Xu Y, et al. Autophagy. 2020 Jan;16(1):3-17. doi: 10.1080/15548627.2019.1603547. Epub 2019 Apr 21. Autophagy. 2020. PMID: 30951392 Free PMC article.
In addition, we further discuss the direct and indirect evidence linking mitophagy to inflammation and autoimmunity underlying the pathogenesis of autoimmune diseases including inflammatory bowel diseases (IBD), systemic lupus erythematosus (SLE) and primary biliary cirrhosis (PB …
In addition, we further discuss the direct and indirect evidence linking mitophagy to inflammation and autoimmunity underlying the pathogene …
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Larabi A, Barnich N, Nguyen HTT. Larabi A, et al. Autophagy. 2020 Jan;16(1):38-51. doi: 10.1080/15548627.2019.1635384. Epub 2019 Jul 9. Autophagy. 2020. PMID: 31286804 Free PMC article. Review.
A better understanding of the role of autophagy in IBD pathogenesis may provide better sub-classification of IBD phenotypes and novel approaches for disease management.Abbreviations: AIEC: adherent-invasive Escherichia coli; AMPK: AMP-activated protein kinase; ATF6: activating tr …
A better understanding of the role of autophagy in IBD pathogenesis may provide better sub-classification of IBD phenotypes and novel approa …
The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy.
Mehto S, Jena KK, Nath P, Chauhan S, Kolapalli SP, Das SK, Sahoo PK, Jain A, Taylor GA, Chauhan S. Mehto S, et al. Mol Cell. 2019 Feb 7;73(3):429-445.e7. doi: 10.1016/j.molcel.2018.11.018. Epub 2019 Jan 3. Mol Cell. 2019. PMID: 30612879 Free PMC article.
Several large-scale genome-wide association studies genetically linked IRGM to Crohn's disease and other inflammatory disorders in which the IRGM appears to have a protective function. ...Further, IRGM mediates selective autophagic degradation of NLRP3 and AS …
Several large-scale genome-wide association studies genetically linked IRGM to Crohn's disease and other inflammatory disorders in wh …
IRGM restrains NLRP3 inflammasome activation by mediating its SQSTM1/p62-dependent selective autophagy.
Mehto S, Chauhan S, Jena KK, Chauhan NR, Nath P, Sahu R, Dhar K, Das SK, Chauhan S. Mehto S, et al. Autophagy. 2019 Sep;15(9):1645-1647. doi: 10.1080/15548627.2019.1628544. Epub 2019 Jun 20. Autophagy. 2019. PMID: 31177914 Free PMC article.
However, the mechanisms employed by IRGM to restrain the inflammation are not known. In our recent study, we showed that IRGM negatively regulates NLRP3 inflammasome activation. IRGM employs 2 parallel approaches to constrain inflammasome activation. ...
However, the mechanisms employed by IRGM to restrain the inflammation are not known. In our recent study, we showed that IRGM
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Mehrbod P, Ande SR, Alizadeh J, Rahimizadeh S, Shariati A, Malek H, Hashemi M, Glover KKM, Sher AA, Coombs KM, Ghavami S. Mehrbod P, et al. Virulence. 2019 Dec;10(1):376-413. doi: 10.1080/21505594.2019.1605803. Virulence. 2019. PMID: 30966844 Free PMC article. Review.
Abbreviation: AIDS: Acquired Immunodeficiency Syndrome; ATF6: Activating Transcription Factor 6; ATG6: Autophagy-specific Gene 6; BAG3: BCL Associated Athanogene 3; Bak: BCL-2-Anatagonist/Killer1; Bax; BCL-2: Associated X protein; Bcl-2: B cell Lymphoma 2x; BiP: Chaperon immunogl …
Abbreviation: AIDS: Acquired Immunodeficiency Syndrome; ATF6: Activating Transcription Factor 6; ATG6: Autophagy-specific Gene 6; BAG3: BCL …
Emerging Mechanisms in Initiating and Terminating Autophagy.
Antonioli M, Di Rienzo M, Piacentini M, Fimia GM. Antonioli M, et al. Trends Biochem Sci. 2017 Jan;42(1):28-41. doi: 10.1016/j.tibs.2016.09.008. Epub 2016 Oct 17. Trends Biochem Sci. 2017. PMID: 27765496 Review.
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
Liu JZ, van Sommeren S, Huang H, Ng SC, Alberts R, Takahashi A, Ripke S, Lee JC, Jostins L, Shah T, Abedian S, Cheon JH, Cho J, Dayani NE, Franke L, Fuyuno Y, Hart A, Juyal RC, Juyal G, Kim WH, Morris AP, Poustchi H, Newman WG, Midha V, Orchard TR, Vahedi H, Sood A, Sung JY, Malekzadeh R, Westra HJ, Yamazaki K, Yang SK; International Multiple Sclerosis Genetics Consortium; International IBD Genetics Consortium, Barrett JC, Alizadeh BZ, Parkes M, Bk T, Daly MJ, Kubo M, Anderson CA, Weersma RK. Liu JZ, et al. Nat Genet. 2015 Sep;47(9):979-986. doi: 10.1038/ng.3359. Epub 2015 Jul 20. Nat Genet. 2015. PMID: 26192919 Free PMC article.
Nevertheless, we observe genetic heterogeneity between divergent populations at several established risk loci driven by differences in allele frequency (NOD2) or effect size (TNFSF15 and ATG16L1) or a combination of these factors (IL23R and IRGM). Our results provide biolo …
Nevertheless, we observe genetic heterogeneity between divergent populations at several established risk loci driven by differences in allel …
Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response.
Jena KK, Mehto S, Nath P, Chauhan NR, Sahu R, Dhar K, Das SK, Kolapalli SP, Murmu KC, Jain A, Krishna S, Sahoo BS, Chattopadhyay S, Rusten TE, Prasad P, Chauhan S, Chauhan S. Jena KK, et al. EMBO Rep. 2020 Sep 3;21(9):e50051. doi: 10.15252/embr.202050051. Epub 2020 Jul 27. EMBO Rep. 2020. PMID: 32715615 Free PMC article.
Here, we found that IRGM is a master negative regulator of the interferon response. Several nucleic acid-sensing pathways leading to interferon-stimulated gene expression are highly activated in IRGM knockout mice and human cells. ...Taken together, this study defin …
Here, we found that IRGM is a master negative regulator of the interferon response. Several nucleic acid-sensing pathways leading to …
IRGM Links Autoimmunity to Autophagy.
Nath P, Jena KK, Mehto S, Chauhan NR, Sahu R, Dhar K, Srinivas K, Chauhan S, Chauhan S. Nath P, et al. Autophagy. 2020 Aug 19. doi: 10.1080/15548627.2020.1810920. Online ahead of print. Autophagy. 2020. PMID: 32813580
IRGM is a genetic risk factor for several autoimmune diseases. However, the mechanism of IRGM-mediated protection in autoimmunity remains undetermined. ...Mechanistically, IRGM utilizes a two-pronged mechanism to suppress the interferon response. ...
IRGM is a genetic risk factor for several autoimmune diseases. However, the mechanism of IRGM-mediated protection in autoimmun
Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens.
Kumar S, Jain A, Choi SW, da Silva GPD, Allers L, Mudd MH, Peters RS, Anonsen JH, Rusten TE, Lazarou M, Deretic V. Kumar S, et al. Nat Cell Biol. 2020 Aug;22(8):973-985. doi: 10.1038/s41556-020-0549-1. Epub 2020 Aug 3. Nat Cell Biol. 2020. PMID: 32753672
IRGM directly interacted with TFEB and promoted the nuclear translocation of TFEB. ...IRGM and GABARAPs countered the action of mTOR as a negative regulator of TFEB. ...
IRGM directly interacted with TFEB and promoted the nuclear translocation of TFEB. ...IRGM and GABARAPs countered the action o
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