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Differences in immune recognition of cytochrome P4502D6 by liver kidney microsomal (LKM) antibody in autoimmune hepatitis and chronic hepatitis C virus infection.
Ma Y, Peakman M, Lobo-Yeo A, Wen L, Lenzi M, Gäken J, Farzaneh F, Mieli-Vergani G, Bianchi FB, Vergani D. Ma Y, et al. Clin Exp Immunol. 1994 Jul;97(1):94-9. doi: 10.1111/j.1365-2249.1994.tb06585.x. Clin Exp Immunol. 1994. PMID: 8033426 Free PMC article.
LKM-1 antibody, which characterizes a subtype of autoimmune hepatitis (AIH), is also found in some patients with chronic hepatitis C virus (HCV) infection. ...Reactivity to CYP2D6 was found in 72% of the anti-HCV-negative, but only in 27% of the anti-HCV-positive pa
LKM-1 antibody, which characterizes a subtype of autoimmune hepatitis (AIH), is also found in some patients with chronic hepat
LKM antibody: getting in some target practice.
Vergani D. Vergani D. Gut. 2000 Apr;46(4):449-50. doi: 10.1136/gut.46.4.449. Gut. 2000. PMID: 10716668 Free PMC article. No abstract available.
Historical reflections on autoimmune hepatitis.
Mackay IR. Mackay IR. World J Gastroenterol. 2008 Jun 7;14(21):3292-300. doi: 10.3748/wjg.14.3292. World J Gastroenterol. 2008. PMID: 18528926 Free PMC article. Review.
Disease-characteristic autoantibodies were defined from the early 1960s, notably antinuclear antibody (ANA), smooth muscle antibody (SMA) and liver-kidney microsomal (LKM) antibody. ...
Disease-characteristic autoantibodies were defined from the early 1960s, notably antinuclear antibody (ANA), smooth muscle antibod
Distinction between natural and pathological autoantibodies by immunoblotting and densitometric subtraction: liver-kidney microsomal antibody (LKM) positive sera identify multiple antigens in human liver tissue.
Kyriatsoulis A, Manns M, Gerken G, Lohse AW, Ballhausen W, Reske K, Meyer zum Büschenfelde KH. Kyriatsoulis A, et al. Clin Exp Immunol. 1987 Oct;70(1):53-60. Clin Exp Immunol. 1987. PMID: 3690894 Free PMC article.
Using one-dimensional and two-dimensional immunoblotting techniques the reactions of sera from 14 patients with liver-kidney microsomal (LKM) antibody positive chronic active hepatitis (CAH) with human liver microsomal preparations was compared with the reaction of …
Using one-dimensional and two-dimensional immunoblotting techniques the reactions of sera from 14 patients with liver-kidney microsomal ( …
Autoantibody profile in children with Kawasaki disease on long-term follow-up: A prospective study from North India.
Basha A, Rawat A, Jindal AK, Gupta A, Anand S, Garg R, Minz RW, Singh S. Basha A, et al. Int J Rheum Dis. 2018 Nov;21(11):2036-2040. doi: 10.1111/1756-185X.13372. Epub 2018 Aug 30. Int J Rheum Dis. 2018. PMID: 30168280
The organ-specific autoantibodies that were assessed in the study included anti-thyroid microsomal antibody (TMA), anti-parietal cell antibody (PCA) and anti-liver kidney microsomal (LKM) antibody. The organ-nonspecific autoantibodies that were studied …
The organ-specific autoantibodies that were assessed in the study included anti-thyroid microsomal antibody (TMA), anti-parietal cell …
[The microsomal antibody (LKM) in liver pathology: its association with other autoantibodies].
Ruffatti A, Chiaramonte M, Sebastianelli A, Naccarato R. Ruffatti A, et al. Boll Ist Sieroter Milan. 1980 Sep 30;59(4):359-65. Boll Ist Sieroter Milan. 1980. PMID: 6970582 Italian.
Twenty patients found LKM antibody positive during the routine screening for autoantibodies, were studied for the association with other autoantibodies. ...Eleven patients (55%) were over 40 years old, 3 patients were HBsAg+ve, 4 have toxic and alcohol-related liver …
Twenty patients found LKM antibody positive during the routine screening for autoantibodies, were studied for the association …
Prevalence and Significance of Autoantibodies in Children With Acute Liver Failure.
Narkewicz MR, Horslen S, Belle SH, Rudnick DA, Ng VL, Rosenthal P, Romero R, Loomes KM, Zhang S, Hardison RM, Squires RH; Pediatric Acute Liver Failure Study Group. Narkewicz MR, et al. J Pediatr Gastroenterol Nutr. 2017 Feb;64(2):210-217. doi: 10.1097/MPG.0000000000001363. J Pediatr Gastroenterol Nutr. 2017. PMID: 27496798 Free PMC article.
OBJECTIVES: The purpose of the present study is to estimate autoantibody (auto-AB) frequency, clinical characteristics, and 21-day outcome of participants in the Pediatric Acute Liver Failure Study Group (PALFSG) by antinuclear antibody, smooth muscle antibody, and …
OBJECTIVES: The purpose of the present study is to estimate autoantibody (auto-AB) frequency, clinical characteristics, and 21-day outcome o …
[Immunology of liver diseases].
Meyer zum Büschenfelde KH. Meyer zum Büschenfelde KH. Schweiz Med Wochenschr. 1987 Jul 18;117(29):1065-75. Schweiz Med Wochenschr. 1987. PMID: 3313682 Review. German.
Autoimmune type chronic active hepatitis (CAH) is classified into classical autoimmune type "lupoid CAH" with antinuclear antibodies and liver membrane antibodies as markers, liver-kidney-microsomal (LKM) antibody positive CAH, CAH associated with autoantibodies aga …
Autoimmune type chronic active hepatitis (CAH) is classified into classical autoimmune type "lupoid CAH" with antinuclear antibodies and liv …
Chronic active hepatitis associated with vitiligo, nail dystrophy, alopecia and a new variant of LKM antibodies.
Sacher M, Blümel P, Thaler H, Manns M. Sacher M, et al. J Hepatol. 1990 May;10(3):364-9. doi: 10.1016/0168-8278(90)90148-k. J Hepatol. 1990. PMID: 2195110
In Western blot analysis this LKM variant reacts with a liver microsomal protein of approx. 50 kDa, but not with recombinant LKM-1 (cytochrome P450 db1) antigen. ...Furthermore, this patient suffers from extrahepatic syndromes (alopecia, nail dystrophy) that have no …
In Western blot analysis this LKM variant reacts with a liver microsomal protein of approx. 50 kDa, but not with recombinant LKM
Liver cytosolic 1 antigen-antibody system in type 2 autoimmune hepatitis and hepatitis C virus infection.
Lenzi M, Manotti P, Muratori L, Cataleta M, Ballardini G, Cassani F, Bianchi FB. Lenzi M, et al. Gut. 1995 May;36(5):749-54. doi: 10.1136/gut.36.5.749. Gut. 1995. PMID: 7797126 Free PMC article.
Within the multiform liver/kidney microsomal (LKM) family, a subgroup of sera that reacts with a liver cytosolic (LC) protein has been isolated and the new antigen-antibody system is called LC1. Unlike LKM antibody type 1 (anti-LKM1), anti-LC1 is said …
Within the multiform liver/kidney microsomal (LKM) family, a subgroup of sera that reacts with a liver cytosolic (LC) protein has bee …
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